3J9M
| Structure of the human mitochondrial ribosome (class 1) | 分子名称: | 12S rRNA, 16S rRNA, E-site tRNA, ... | 著者 | Amunts, A, Brown, A, Toots, J, Scheres, S.H, Ramakrishnan, V. | 登録日 | 2015-02-08 | 公開日 | 2015-04-15 | 最終更新日 | 2018-07-18 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Ribosome. The structure of the human mitochondrial ribosome. Science, 348, 2015
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6OKK
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5UMD
| Structure of the Plasmodium falciparum 80S ribosome bound to the antimalarial drug mefloquine | 分子名称: | 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... | 著者 | Wong, W, Bai, X.-C, Brown, A, Scheres, S, Baum, J. | 登録日 | 2017-01-27 | 公開日 | 2017-03-01 | 最終更新日 | 2019-12-11 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis. Nat Microbiol, 2, 2017
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5GAO
| Head region of the yeast spliceosomal U4/U6.U5 tri-snRNP | 分子名称: | Pre-mRNA-splicing factor 8, Pre-mRNA-splicing helicase BRR2, Saccharomyces cerevisiae strain UOA_M2 chromosome 5 sequence, ... | 著者 | Nguyen, T.H.D, Galej, W.P, Bai, X.C, Oubridge, C, Scheres, S.H.W, Newman, A.J, Nagai, K. | 登録日 | 2015-12-15 | 公開日 | 2016-01-27 | 最終更新日 | 2019-10-02 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 angstrom resolution. Nature, 530, 2016
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5GAN
| The overall structure of the yeast spliceosomal U4/U6.U5 tri-snRNP at 3.7 Angstrom | 分子名称: | 13 kDa ribonucleoprotein-associated protein, GUANOSINE-5'-TRIPHOSPHATE, Pre-mRNA-processing factor 31, ... | 著者 | Nguyen, T.H.D, Galej, W.P, Bai, X.C, Oubridge, C, Scheres, S.H.W, Newman, A.J, Nagai, K. | 登録日 | 2015-12-15 | 公開日 | 2016-01-27 | 最終更新日 | 2019-12-11 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 angstrom resolution. Nature, 530, 2016
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5M1S
| Cryo-EM structure of the E. coli replicative DNA polymerase-clamp-exonuclase-theta complex bound to DNA in the editing mode | 分子名称: | DNA Primer Strand, DNA Template Strand, DNA polymerase III subunit alpha, ... | 著者 | Fernandez-Leiro, R, Conrad, J, Scheres, S.H.W, Lamers, M.H. | 登録日 | 2016-10-10 | 公開日 | 2017-01-18 | 最終更新日 | 2018-10-24 | 実験手法 | ELECTRON MICROSCOPY (6.7 Å) | 主引用文献 | Self-correcting mismatches during high-fidelity DNA replication. Nat. Struct. Mol. Biol., 24, 2017
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5MZ6
| Cryo-EM structure of a Separase-Securin complex from Caenorhabditis elegans at 3.8 A resolution | 分子名称: | Interactor of FizzY protein, SEParase | 著者 | Boland, A, Martin, T.G, Zhang, Z, Yang, J, Bai, X.C, Chang, L, Scheres, S.H.W, Barford, D. | 登録日 | 2017-01-31 | 公開日 | 2017-03-08 | 最終更新日 | 2019-12-11 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Cryo-EM structure of a metazoan separase-securin complex at near-atomic resolution. Nat. Struct. Mol. Biol., 24, 2017
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6QJP
| Cryo-EM structure of heparin-induced 2N4R tau jagged filaments | 分子名称: | Microtubule-associated protein tau | 著者 | Zhang, W, Falcon, B, Murzin, A.G, Fan, J, Crowther, R.A, Goedert, M, Scheres, S.H.W. | 登録日 | 2019-01-24 | 公開日 | 2019-02-20 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer's and Pick's diseases. Elife, 8, 2019
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6QJH
| Cryo-EM structure of heparin-induced 2N4R tau snake filaments | 分子名称: | Microtubule-associated protein tau | 著者 | Zhang, W, Falcon, B, Murzin, A.G, Fan, J, Crowther, R.A, Goedert, M, Scheres, S.H.W. | 登録日 | 2019-01-24 | 公開日 | 2019-02-20 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer's and Pick's diseases. Elife, 8, 2019
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6QJM
| Cryo-EM structure of heparin-induced 2N4R tau twister filaments | 分子名称: | Microtubule-associated protein tau | 著者 | Zhang, W, Falcon, B, Murzin, A.G, Fan, J, Crowther, R.A, Goedert, M, Scheres, S.H.W. | 登録日 | 2019-01-24 | 公開日 | 2019-02-27 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer's and Pick's diseases. Elife, 8, 2019
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6QJQ
| Cryo-EM structure of heparin-induced 2N3R tau filaments | 分子名称: | Microtubule-associated protein tau | 著者 | Zhang, W, Falcon, B, Murzin, A.G, Fan, J, Crowther, R.A, Goedert, M, Scheres, S.H.W. | 登録日 | 2019-01-24 | 公開日 | 2019-02-20 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer's and Pick's diseases. Elife, 8, 2019
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6RZA
| Cryo-EM structure of the human inner arm dynein DNAH7 microtubule binding domain bound to microtubules | 分子名称: | Cytoplasmic dynein 1 heavy chain 1,Dynein heavy chain 7, axonemal,Cytoplasmic dynein 1 heavy chain 1, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Lacey, S.E, He, S, Scheres, S.H.W, Carter, A.P. | 登録日 | 2019-06-13 | 公開日 | 2019-07-10 | 最終更新日 | 2019-07-17 | 実験手法 | ELECTRON MICROSCOPY (5.4 Å) | 主引用文献 | Cryo-EM of dynein microtubule-binding domains shows how an axonemal dynein distorts the microtubule. Elife, 8, 2019
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6RZB
| Cryo-EM structure of mouse cytoplasmic dynein-1 microtubule binding domain bound to microtubules | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Lacey, S.E, He, S, Scheres, S.H.W, Carter, A.P. | 登録日 | 2019-06-13 | 公開日 | 2019-07-10 | 最終更新日 | 2019-07-17 | 実験手法 | ELECTRON MICROSCOPY (5 Å) | 主引用文献 | Cryo-EM of dynein microtubule-binding domains shows how an axonemal dynein distorts the microtubule. Elife, 8, 2019
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5GAP
| Body region of the U4/U6.U5 tri-snRNP | 分子名称: | 13 kDa ribonucleoprotein-associated protein, Pre-mRNA-processing factor 31, Pre-mRNA-splicing factor 6, ... | 著者 | Nguyen, T.H.D, Galej, W.P, Oubridge, C, Bai, X.C, Newman, A, Scheres, S, Nagai, K. | 登録日 | 2015-12-15 | 公開日 | 2016-01-27 | 最終更新日 | 2019-10-02 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 angstrom resolution. Nature, 530, 2016
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5FKU
| cryo-EM structure of the E. coli replicative DNA polymerase complex in DNA free state (DNA polymerase III alpha, beta, epsilon, tau complex) | 分子名称: | DNA POLYMERASE III SUBUNIT ALPHA, DNA POLYMERASE III SUBUNIT BETA, DNA POLYMERASE III SUBUNIT EPSILON, ... | 著者 | Fernandez-Leiro, R, Conrad, J, Scheres, S.H.W, Lamers, M.H. | 登録日 | 2015-10-20 | 公開日 | 2015-11-25 | 最終更新日 | 2019-05-08 | 実験手法 | ELECTRON MICROSCOPY (8.34 Å) | 主引用文献 | cryo-EM structures of theE. colireplicative DNA polymerase reveal its dynamic interactions with the DNA sliding clamp, exonuclease andtau. Elife, 4, 2015
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5FN3
| Cryo-EM structure of gamma secretase in class 1 of the apo- state ensemble | 分子名称: | Gamma-secretase subunit APH-1A, Gamma-secretase subunit PEN-2, Nicastrin, ... | 著者 | Bai, X.C, Rajendra, E, Yang, G.H, Shi, Y.G, Scheres, S.H.W. | 登録日 | 2015-11-10 | 公開日 | 2015-12-16 | 最終更新日 | 2019-09-11 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Sampling the conformational space of the catalytic subunit of human gamma-secretase. Elife, 4, 2015
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5FN2
| Cryo-EM structure of gamma secretase in complex with a drug DAPT | 分子名称: | Gamma-secretase subunit APH-1A, Gamma-secretase subunit PEN-2, Nicastrin, ... | 著者 | Bai, X.C, Rajendra, E, Yang, G.H, Shi, Y.G, Scheres, S.H.W. | 登録日 | 2015-11-10 | 公開日 | 2015-12-16 | 最終更新日 | 2019-09-04 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Sampling the conformational space of the catalytic subunit of human gamma-secretase. Elife, 4, 2015
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5FN4
| Cryo-EM structure of gamma secretase in class 2 of the apo- state ensemble | 分子名称: | Gamma-secretase subunit APH-1A, Gamma-secretase subunit PEN-2, Nicastrin, ... | 著者 | Bai, X.C, Rajendra, E, Yang, G.H, Shi, Y.G, Scheres, S.H.W. | 登録日 | 2015-11-10 | 公開日 | 2015-12-16 | 最終更新日 | 2019-09-11 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Sampling the conformational space of the catalytic subunit of human gamma-secretase. Elife, 4, 2015
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5FKW
| cryo-EM structure of the E. coli replicative DNA polymerase complex bound to DNA (DNA polymerase III alpha, beta, epsilon) | 分子名称: | DNA POLYMERASE III ALPHA, DNA POLYMERASE III BETA, DNA POLYMERASE III EPSILON, ... | 著者 | Fernandez-Leiro, R, Conrad, J, Scheres, S.H.W, Lamers, M.H. | 登録日 | 2015-10-20 | 公開日 | 2015-11-25 | 最終更新日 | 2019-02-27 | 実験手法 | ELECTRON MICROSCOPY (7.3 Å) | 主引用文献 | cryo-EM structures of theE. colireplicative DNA polymerase reveal its dynamic interactions with the DNA sliding clamp, exonuclease andtau. Elife, 4, 2015
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5FN5
| Cryo-EM structure of gamma secretase in class 3 of the apo- state ensemble | 分子名称: | Gamma-secretase subunit APH-1A, Gamma-secretase subunit PEN-2, Nicastrin, ... | 著者 | Bai, X.C, Rajendra, E, Yang, G.H, Shi, Y.G, Scheres, S.H.W. | 登録日 | 2015-11-10 | 公開日 | 2015-12-16 | 最終更新日 | 2019-09-11 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Sampling the conformational space of the catalytic subunit of human gamma-secretase. Elife, 4, 2015
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5FKV
| cryo-EM structure of the E. coli replicative DNA polymerase complex bound to DNA (DNA polymerase III alpha, beta, epsilon, tau complex) | 分子名称: | DNA POLYMERASE III BETA, DNA POLYMERASE III EPSILON, DNA POLYMERASE III SUBUNIT ALPHA, ... | 著者 | Fernandez-Leiro, R, Conrad, J, Scheres, S.H.W, Lamers, M.H. | 登録日 | 2015-10-20 | 公開日 | 2015-11-25 | 最終更新日 | 2019-02-27 | 実験手法 | ELECTRON MICROSCOPY (8 Å) | 主引用文献 | cryo-EM structures of theE. colireplicative DNA polymerase reveal its dynamic interactions with the DNA sliding clamp, exonuclease andtau. Elife, 4, 2015
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8G8F
| Human IMPDH2 mutant - L245P, treated with ATP, IMP, and NAD+; extended filament segment reconstruction | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, Inosine-5'-monophosphate dehydrogenase 2, ... | 著者 | O'Neill, A.G, Kollman, J.M. | 登録日 | 2023-02-17 | 公開日 | 2023-04-19 | 最終更新日 | 2023-08-09 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Neurodevelopmental disorder mutations in the purine biosynthetic enzyme IMPDH2 disrupt its allosteric regulation. J.Biol.Chem., 299, 2023
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8G9B
| Human IMPDH2 mutant - L245P, treated with GTP, ATP, IMP, and NAD+; compressed filament segment reconstruction | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, ... | 著者 | O'Neill, A.G, Kollman, J.M. | 登録日 | 2023-02-21 | 公開日 | 2023-04-19 | 最終更新日 | 2023-08-09 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Neurodevelopmental disorder mutations in the purine biosynthetic enzyme IMPDH2 disrupt its allosteric regulation. J.Biol.Chem., 299, 2023
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5LJW
| MamK non-polymerising A278D mutant bound to AMPPNP | 分子名称: | Actin-like ATPase, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | 著者 | Lowe, J. | 登録日 | 2016-07-20 | 公開日 | 2016-11-16 | 最終更新日 | 2017-08-30 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | X-ray and cryo-EM structures of monomeric and filamentous actin-like protein MamK reveal changes associated with polymerization. Proc. Natl. Acad. Sci. U.S.A., 113, 2016
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5LJV
| MamK double helical filament | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin-like ATPase, MAGNESIUM ION | 著者 | Lowe, J. | 登録日 | 2016-07-21 | 公開日 | 2016-11-16 | 最終更新日 | 2019-10-23 | 実験手法 | ELECTRON MICROSCOPY (3.65 Å) | 主引用文献 | X-ray and cryo-EM structures of monomeric and filamentous actin-like protein MamK reveal changes associated with polymerization. Proc. Natl. Acad. Sci. U.S.A., 113, 2016
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