8BQ7
 
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6QVG
 | | Human SHMT2 in complex with lometrexol | | 分子名称: | 5,10-DIDEAZATETRAHYDROFOLIC ACID, ACETATE ION, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Scaletti, E, Jemth, A.S, Helleday, T, Stenmark, P. | | 登録日 | 2019-03-01 | | 公開日 | 2019-09-04 | | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | | 主引用文献 | Structural basis of inhibition of the human serine hydroxymethyltransferase SHMT2 by antifolate drugs.
Febs Lett., 593, 2019
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6QVL
 | | Human SHMT2 in complex with pemetrexed | | 分子名称: | CALCIUM ION, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | | 著者 | Scaletti, E, Jemth, A.S, Helleday, T, Stenmark, P. | | 登録日 | 2019-03-03 | | 公開日 | 2019-09-04 | | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | | 主引用文献 | Structural basis of inhibition of the human serine hydroxymethyltransferase SHMT2 by antifolate drugs.
Febs Lett., 593, 2019
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7Z5B
 | | Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with ligand TH013546 | | 分子名称: | 2-[4-(2,4-dimethyl-1~{H}-imidazol-5-yl)phenyl]-~{N}-(4,5,6,7-tetrahydro-1,2-benzoxazol-3-yl)ethanamide, N-glycosylase/DNA lyase, NICKEL (II) ION | | 著者 | Scaletti, E, Stenmark, P. | | 登録日 | 2022-03-08 | | 公開日 | 2023-03-22 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with ligand TH013546
To Be Published
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8A0T
 | | MTH1 in complex with TH012532 | | 分子名称: | 5-(phenylmethyl)pyrimidine-2,4-diol, 7,8-dihydro-8-oxoguanine triphosphatase, ACETATE ION, ... | | 著者 | Scaletti, E, Stenmark, P. | | 登録日 | 2022-05-30 | | 公開日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | MTH1 in complex with TH012532
To Be Published
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6TVE
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6TVG
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6Z9B
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8B8I
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7Z5R
 | | Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with ligand TH012035 | | 分子名称: | (7~{R})-~{N}-(4,5,6,7-tetrahydro-1,2-benzoxazol-3-yl)bicyclo[4.2.0]octa-1,3,5-triene-7-carboxamide, N-glycosylase/DNA lyase, NICKEL (II) ION | | 著者 | Davies, J.R, Scaletti, E, Stenmark, P. | | 登録日 | 2022-03-09 | | 公開日 | 2023-03-22 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with ligand TH012035
To Be Published
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7ZC7
 | | Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with ligand TH012941 | | 分子名称: | 2-[4-(3,5-dimethylpyrazol-1-yl)phenyl]-~{N}-(4,5,6,7-tetrahydro-1,2-benzoxazol-3-yl)ethanamide, N-glycosylase/DNA lyase, NICKEL (II) ION | | 著者 | Davies, J.R, Scaletti, E, Stenmark, P. | | 登録日 | 2022-03-25 | | 公開日 | 2023-07-05 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with ligand TH012941
To Be Published
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7ZG3
 | | Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with ligand TH011228 | | 分子名称: | N-glycosylase/DNA lyase, NICKEL (II) ION, ~{N}-[(1~{S})-1,2,2-trimethylcyclopropyl]pyrrolo[1,2-c]pyrimidine-3-carboxamide | | 著者 | Davies, J.R, Scaletti, E, Stenmark, P. | | 登録日 | 2022-04-01 | | 公開日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with ligand TH011228
To Be Published
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8A0S
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8A3A
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8A34
 | | MTH1 in complex with TH013071 | | 分子名称: | 5-(2-phenylphenyl)-1H-pyrimidine-2,4-dione, 7,8-dihydro-8-oxoguanine triphosphatase, ACETATE ION, ... | | 著者 | Liu, H, Scaletti, E, Stenmark, P. | | 登録日 | 2022-06-07 | | 公開日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | MTH1 in complex with TH013071
To Be Published
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6YE2
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6YE1
 | | Human Ecto-5'-nucleotidase (CD73) in complex with the AMPCP derivative A894 (compound 2n in publication) in the closed form (crystal form IV) | | 分子名称: | 5'-nucleotidase, ZINC ION, [(2~{R},3~{S},4~{R},5~{R})-5-[2-chloranyl-6-(cyclopentylamino)purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxymethylphosphonic acid | | 著者 | Scaletti, E, Strater, N. | | 登録日 | 2020-03-23 | | 公開日 | 2021-01-20 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.66 Å) | | 主引用文献 | Discovery of Potent and Selective Methylenephosphonic Acid CD73 Inhibitors.
J.Med.Chem., 64, 2021
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8B5S
 | | Crystal Structure of P. aeruginosa WaaG in complex with UDP-glucose | | 分子名称: | UDP-glucose:(Heptosyl) LPS alpha 1,3-glucosyltransferase WaaG, URIDINE-5'-DIPHOSPHATE, URIDINE-5'-DIPHOSPHATE-GLUCOSE | | 著者 | Scaletti, E, Gustafsson Westergren, R, Stenmark, P. | | 登録日 | 2022-09-24 | | 公開日 | 2023-10-04 | | 最終更新日 | 2024-04-17 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Structural and functional insights into the Pseudomonas aeruginosa glycosyltransferase WaaG and the implications for lipopolysaccharide biosynthesis.
J.Biol.Chem., 299, 2023
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8B5Q
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8B62
 | | Crystal Structure of P. aeruginosa WaaG in complex with UDP-galactose | | 分子名称: | GALACTOSE-URIDINE-5'-DIPHOSPHATE, GLYCEROL, UDP-glucose:(Heptosyl) LPS alpha 1,3-glucosyltransferase WaaG | | 著者 | Scaletti, E, Gustafsson Westergren, R, Stenmark, P. | | 登録日 | 2022-09-25 | | 公開日 | 2023-10-04 | | 最終更新日 | 2024-04-17 | | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | | 主引用文献 | Structural and functional insights into the Pseudomonas aeruginosa glycosyltransferase WaaG and the implications for lipopolysaccharide biosynthesis.
J.Biol.Chem., 299, 2023
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8B63
 | | Crystal Structure of P. aeruginosa WaaG in complex with UDP-GalNAc | | 分子名称: | ACETATE ION, UDP-glucose:(Heptosyl) LPS alpha 1,3-glucosyltransferase WaaG, URIDINE-5'-DIPHOSPHATE, ... | | 著者 | Scaletti, E, Gustafsson Westergren, R, Stenmark, P. | | 登録日 | 2022-09-25 | | 公開日 | 2023-10-04 | | 最終更新日 | 2024-04-17 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structural and functional insights into the Pseudomonas aeruginosa glycosyltransferase WaaG and the implications for lipopolysaccharide biosynthesis.
J.Biol.Chem., 299, 2023
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6SQY
 | | Mouse dCTPase in complex with dCMP | | 分子名称: | 2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE, MAGNESIUM ION, dCTP pyrophosphatase 1 | | 著者 | Scaletti, E.R, Claesson, M, Helleday, H, Jemth, A.S, Stenmark, P. | | 登録日 | 2019-09-04 | | 公開日 | 2020-01-29 | | 最終更新日 | 2020-03-11 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The First Structure of an Active Mammalian dCTPase and its Complexes With Substrate Analogs and Products.
J.Mol.Biol., 432, 2020
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6SQW
 | | Mouse dCTPase in complex with 5-Me-dCMP | | 分子名称: | 5-METHYL-2'-DEOXY-CYTIDINE-5'-MONOPHOSPHATE, MAGNESIUM ION, dCTP pyrophosphatase 1 | | 著者 | Scaletti, E.R, Claesson, M, Helleday, H, Jemth, A.S, Stenmark, P. | | 登録日 | 2019-09-04 | | 公開日 | 2020-01-29 | | 最終更新日 | 2020-03-11 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | The First Structure of an Active Mammalian dCTPase and its Complexes With Substrate Analogs and Products.
J.Mol.Biol., 432, 2020
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6SQZ
 | | Mouse dCTPase in complex with dCMPNPP | | 分子名称: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, MAGNESIUM ION, dCTP pyrophosphatase 1 | | 著者 | Scaletti, E.R, Claesson, M, Helleday, H, Jemth, A.S, Stenmark, P. | | 登録日 | 2019-09-04 | | 公開日 | 2020-01-29 | | 最終更新日 | 2020-03-11 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The First Structure of an Active Mammalian dCTPase and its Complexes With Substrate Analogs and Products.
J.Mol.Biol., 432, 2020
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7P9T
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