6QVL

Human SHMT2 in complex with pemetrexed

Summary for 6QVL

• Entry DOI: 10.2210/pdb6qvl/pdb
• Descriptor: Serine hydroxymethyltransferase, mitochondrial, GLYCEROL, DI(HYDROXYETHYL)ETHER, ... (7 entities in total)
• Functional Keywords: transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 113477.92

Authors

Scaletti, E.,Jemth, A.S.,Helleday, T.,Stenmark, P. (deposition date: 2019-03-03, release date: 2019-09-04)

• Primary citation: Scaletti, E.,Jemth, A.S.,Helleday, T.,Stenmark, P.; Structural basis of inhibition of the human serine hydroxymethyltransferase SHMT2 by antifolate drugs.; Febs Lett., 593:1863-1873, 2019; PubMed: 31127856; DOI: 10.1002/1873-3468.13455

Experimental method

X-RAY DIFFRACTION (2.28 Å)