6QVL
Human SHMT2 in complex with pemetrexed
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Serine hydroxymethyltransferase, mitochondrial | polymer | 504 | 56067.9 | 2 | UniProt (P34897) Pfam (PF00464) | Homo sapiens (Human) | SHMT,Glycine hydroxymethyltransferase,Serine methylase |
| 2 | C, D, H (A, B) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 3 | E (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 4 | F (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 5 | G, J (A, B) | PYRIDOXAL-5'-PHOSPHATE | non-polymer | 247.1 | 2 | Chemie (PLP) | |||
| 6 | I (B) | N-{4-[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamic acid | non-polymer | 425.4 | 1 | Chemie (4DW) | |||
| 7 | K, L (A, B) | water | water | 18.0 | 429 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 112135.8 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1342.2 | |
| All* | Total formula weight | 113477.9 |
