6QVG

Human SHMT2 in complex with lometrexol

Summary for 6QVG

• Entry DOI: 10.2210/pdb6qvg/pdb
• Descriptor: Serine hydroxymethyltransferase, mitochondrial, GLYCINE, DI(HYDROXYETHYL)ETHER, ... (9 entities in total)
• Functional Keywords: transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 114070.48

Authors

Scaletti, E.,Jemth, A.S.,Helleday, T.,Stenmark, P. (deposition date: 2019-03-01, release date: 2019-09-04)

• Primary citation: Scaletti, E.,Jemth, A.S.,Helleday, T.,Stenmark, P.; Structural basis of inhibition of the human serine hydroxymethyltransferase SHMT2 by antifolate drugs.; Febs Lett., 593:1863-1873, 2019; PubMed: 31127856; DOI: 10.1002/1873-3468.13455

Experimental method

X-RAY DIFFRACTION (2.32 Å)