6QVG
Human SHMT2 in complex with lometrexol
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Serine hydroxymethyltransferase, mitochondrial | polymer | 504 | 56067.9 | 2 | UniProt (P34897) Pfam (PF00464) | Homo sapiens (Human) | SHMT,Glycine hydroxymethyltransferase,Serine methylase |
| 2 | C (A) | GLYCINE | non-polymer | 75.1 | 1 | Chemie (GLY) | |||
| 3 | D, E (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 2 | Chemie (PEG) | |||
| 4 | F (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 5 | G, H (A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 6 | I, L (A, B) | 5,10-DIDEAZATETRAHYDROFOLIC ACID | non-polymer | 443.5 | 2 | Chemie (DDF) | |||
| 7 | J, M (A, B) | PYRIDOXAL-5'-PHOSPHATE | non-polymer | 247.1 | 2 | Chemie (PLP) | |||
| 8 | K (B) | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 9 | N, O (A, B) | water | water | 18.0 | 368 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 112135.8 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1934.7 | |
| All* | Total formula weight | 114070.5 |
