6TVE
Unliganded human CD73 (5'-nucleotidase) in the open state
Summary for 6TVE
Entry DOI | 10.2210/pdb6tve/pdb |
Descriptor | 5'-nucleotidase, CALCIUM ION, ZINC ION, ... (6 entities in total) |
Functional Keywords | en, e5nt, dizinc, ecto-nucleotidase, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 61536.58 |
Authors | Scaletti, E.,Strater, N. (deposition date: 2020-01-09, release date: 2020-02-19, Last modification date: 2024-01-24) |
Primary citation | Bhattarai, S.,Pippel, J.,Scaletti, E.,Idris, R.,Freundlieb, M.,Rolshoven, G.,Renn, C.,Lee, S.Y.,Abdelrahman, A.,Zimmermann, H.,El-Tayeb, A.,Muller, C.E.,Strater, N. 2-Substituted alpha , beta-Methylene-ADP Derivatives: Potent Competitive Ecto-5'-nucleotidase (CD73) Inhibitors with Variable Binding Modes. J.Med.Chem., 63:2941-2957, 2020 Cited by PubMed: 32045236DOI: 10.1021/acs.jmedchem.9b01611 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.05 Å) |
Structure validation
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