6TVE

Unliganded human CD73 (5'-nucleotidase) in the open state

Summary for 6TVE

Entry DOI	10.2210/pdb6tve/pdb
Descriptor	5'-nucleotidase, CALCIUM ION, ZINC ION, ... (6 entities in total)
Functional Keywords	en, e5nt, dizinc, ecto-nucleotidase, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	61536.58
Authors	Scaletti, E.,Strater, N. (deposition date: 2020-01-09, release date: 2020-02-19, Last modification date: 2024-01-24)
Primary citation	Bhattarai, S.,Pippel, J.,Scaletti, E.,Idris, R.,Freundlieb, M.,Rolshoven, G.,Renn, C.,Lee, S.Y.,Abdelrahman, A.,Zimmermann, H.,El-Tayeb, A.,Muller, C.E.,Strater, N. 2-Substituted alpha , beta-Methylene-ADP Derivatives: Potent Competitive Ecto-5'-nucleotidase (CD73) Inhibitors with Variable Binding Modes. J.Med.Chem., 63:2941-2957, 2020 Cited by PubMed: 32045236 DOI: 10.1021/acs.jmedchem.9b01611 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.05 Å)

Structure validation