6TVE
Unliganded human CD73 (5'-nucleotidase) in the open state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| P | 0000166 | molecular_function | nucleotide binding |
| P | 0002953 | molecular_function | 5'-deoxynucleotidase activity |
| P | 0005515 | molecular_function | protein binding |
| P | 0005654 | cellular_component | nucleoplasm |
| P | 0005829 | cellular_component | cytosol |
| P | 0005886 | cellular_component | plasma membrane |
| P | 0006196 | biological_process | AMP catabolic process |
| P | 0006259 | biological_process | DNA metabolic process |
| P | 0007159 | biological_process | leukocyte cell-cell adhesion |
| P | 0008252 | molecular_function | nucleotidase activity |
| P | 0008253 | molecular_function | 5'-nucleotidase activity |
| P | 0008270 | molecular_function | zinc ion binding |
| P | 0009166 | biological_process | nucleotide catabolic process |
| P | 0009897 | cellular_component | external side of plasma membrane |
| P | 0009986 | cellular_component | cell surface |
| P | 0010035 | biological_process | obsolete response to inorganic substance |
| P | 0016020 | cellular_component | membrane |
| P | 0016787 | molecular_function | hydrolase activity |
| P | 0016788 | molecular_function | hydrolase activity, acting on ester bonds |
| P | 0033198 | biological_process | response to ATP |
| P | 0042802 | molecular_function | identical protein binding |
| P | 0046032 | biological_process | ADP catabolic process |
| P | 0046034 | biological_process | ATP metabolic process |
| P | 0046086 | biological_process | adenosine biosynthetic process |
| P | 0046872 | molecular_function | metal ion binding |
| P | 0050340 | molecular_function | thymidylate 5'-phosphatase activity |
| P | 0050483 | molecular_function | IMP 5'-nucleotidase activity |
| P | 0050484 | molecular_function | GMP 5'-nucleotidase activity |
| P | 0050728 | biological_process | negative regulation of inflammatory response |
| P | 0055074 | biological_process | calcium ion homeostasis |
| P | 0070062 | cellular_component | extracellular exosome |
| P | 0098552 | cellular_component | side of membrane |
| P | 0106411 | molecular_function | XMP 5'-nucleosidase activity |
| P | 0110148 | biological_process | obsolete biomineralization |
| P | 0140928 | biological_process | inhibition of non-skeletal tissue mineralization |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue CA P 601 |
| Chain | Residue |
| P | ASN213 |
| P | ASP237 |
| P | GLY298 |
| P | HOH771 |
| P | HOH991 |
| P | HOH1116 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue ZN P 602 |
| Chain | Residue |
| P | HIS220 |
| P | HIS243 |
| P | ZN603 |
| P | HOH733 |
| P | ASP36 |
| P | ASP85 |
| P | ASN117 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue ZN P 603 |
| Chain | Residue |
| P | ASP36 |
| P | HIS38 |
| P | ASP85 |
| P | SER520 |
| P | ZN602 |
| P | HOH733 |
| P | HOH741 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue DMS P 604 |
| Chain | Residue |
| P | PHE65 |
| P | ARG72 |
| P | ALA107 |
| P | LEU108 |
| P | ARG109 |
| P | HOH959 |
| site_id | AC5 |
| Number of Residues | 10 |
| Details | binding site for residue GOL P 605 |
| Chain | Residue |
| P | GLN88 |
| P | ASP121 |
| P | ASN122 |
| P | ASN371 |
| P | ASP522 |
| P | ASN526 |
| P | THR530 |
| P | HOH954 |
| P | HOH957 |
| P | HOH1169 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue DMS P 606 |
| Chain | Residue |
| P | ARG72 |
| P | ARG73 |
| P | ALA74 |
| P | PRO76 |
| P | PRO149 |
| P | GLN153 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue DMS P 607 |
| Chain | Residue |
| P | TYR334 |
| P | GLN337 |
| P | GLU338 |
| P | LEU339 |
| P | HOH721 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue DMS P 608 |
| Chain | Residue |
| P | TYR281 |
| P | ASN499 |
| P | ASN503 |
| P | HOH772 |
| P | HOH1202 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue DMS P 609 |
| Chain | Residue |
| P | ARG40 |
| P | ASP47 |
| P | PHE417 |
| P | ASN499 |
| P | PHE500 |
| P | HOH881 |
| P | HOH1200 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue GOL P 610 |
| Chain | Residue |
| P | TYR96 |
| P | TRP327 |
| P | HOH701 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue DMS P 611 |
| Chain | Residue |
| P | MET535 |
| P | ILE538 |
| P | TYR539 |
| P | PRO540 |
| P | HOH962 |
| P | HOH1117 |
| site_id | AD3 |
| Number of Residues | 8 |
| Details | binding site for residue GOL P 612 |
| Chain | Residue |
| P | VAL78 |
| P | LEU79 |
| P | ASP111 |
| P | PRO165 |
| P | VAL166 |
| P | GLY167 |
| P | HOH893 |
| P | HOH934 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue DMS P 613 |
| Chain | Residue |
| P | SER155 |
| P | GLY156 |
| P | TYR158 |
| P | HOH1006 |
| site_id | AD5 |
| Number of Residues | 9 |
| Details | binding site for residue DMS P 614 |
| Chain | Residue |
| P | HIS456 |
| P | GLU543 |
| P | GLU543 |
| P | GLY544 |
| P | GLY544 |
| P | LYS547 |
| P | LYS547 |
| P | HOH1151 |
| P | HOH1151 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22997138, ECO:0000269|PubMed:23142347, ECO:0000269|PubMed:34403084, ECO:0007744|PDB:4H1S, ECO:0007744|PDB:7P9N |
| Chain | Residue | Details |
| P | ASP36 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22997138, ECO:0000269|PubMed:23142347, ECO:0000269|PubMed:34403084, ECO:0007744|PDB:4H1S, ECO:0007744|PDB:4H1Y, ECO:0007744|PDB:4H2B, ECO:0007744|PDB:4H2G, ECO:0007744|PDB:4H2I, ECO:0007744|PDB:7P9N |
| Chain | Residue | Details |
| P | HIS38 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22997138, ECO:0000269|PubMed:23142347, ECO:0000269|PubMed:34403084, ECO:0007744|PDB:4H1S, ECO:0007744|PDB:4H1Y, ECO:0007744|PDB:4H2B, ECO:0007744|PDB:4H2F, ECO:0007744|PDB:4H2G, ECO:0007744|PDB:4H2I, ECO:0007744|PDB:7P9N |
| Chain | Residue | Details |
| P | ASP85 | |
| P | ASN117 | |
| P | HIS220 | |
| P | HIS243 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:34403084, ECO:0007744|PDB:7PBA |
| Chain | Residue | Details |
| P | ARG354 | |
| P | ASN390 | |
| P | ARG395 | |
| P | PHE417 | |
| P | PHE500 | |
| P | ASP506 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | SITE: Transition state stabilizer => ECO:0000269|PubMed:23142347 |
| Chain | Residue | Details |
| P | HIS118 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | SITE: Transition state stabilizer => ECO:0000305|PubMed:23142347 |
| Chain | Residue | Details |
| P | ASP121 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | LIPID: GPI-anchor amidated serine => ECO:0000269|PubMed:2129526 |
| Chain | Residue | Details |
| P | SER549 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| P | ASP53 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:22997138, ECO:0000269|PubMed:23142347 |
| Chain | Residue | Details |
| P | ASP311 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973 |
| Chain | Residue | Details |
| P | ASP333 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 |
| Chain | Residue | Details |
| P | ASP403 |
