Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6TVE

Unliganded human CD73 (5'-nucleotidase) in the open state

Functional Information from GO Data

Chain	GOid	namespace	contents
P	0000166	molecular_function	nucleotide binding
P	0002953	molecular_function	5'-deoxynucleotidase activity
P	0005515	molecular_function	protein binding
P	0005886	cellular_component	plasma membrane
P	0006196	biological_process	AMP catabolic process
P	0007159	biological_process	leukocyte cell-cell adhesion
P	0008253	molecular_function	5'-nucleotidase activity
P	0008270	molecular_function	zinc ion binding
P	0009166	biological_process	nucleotide catabolic process
P	0009897	cellular_component	external side of plasma membrane
P	0009986	cellular_component	cell surface
P	0010035	biological_process	obsolete response to inorganic substance
P	0016020	cellular_component	membrane
P	0016787	molecular_function	hydrolase activity
P	0016788	molecular_function	hydrolase activity, acting on ester bonds
P	0033198	biological_process	response to ATP
P	0042802	molecular_function	identical protein binding
P	0046032	biological_process	ADP catabolic process
P	0046034	biological_process	ATP metabolic process
P	0046872	molecular_function	metal ion binding
P	0055074	biological_process	calcium ion homeostasis
P	0070062	cellular_component	extracellular exosome
P	0098552	cellular_component	side of membrane
P	0110148	biological_process	obsolete biomineralization
P	0140928	biological_process	inhibition of non-skeletal tissue mineralization

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue CA P 601

Chain	Residue
P	ASN213
P	ASP237
P	GLY298
P	HOH771
P	HOH991
P	HOH1116

site_id	AC2
Number of Residues	7
Details	binding site for residue ZN P 602

Chain	Residue
P	HIS220
P	HIS243
P	ZN603
P	HOH733
P	ASP36
P	ASP85
P	ASN117

site_id	AC3
Number of Residues	7
Details	binding site for residue ZN P 603

Chain	Residue
P	ASP36
P	HIS38
P	ASP85
P	SER520
P	ZN602
P	HOH733
P	HOH741

site_id	AC4
Number of Residues	6
Details	binding site for residue DMS P 604

Chain	Residue
P	PHE65
P	ARG72
P	ALA107
P	LEU108
P	ARG109
P	HOH959

site_id	AC5
Number of Residues	10
Details	binding site for residue GOL P 605

Chain	Residue
P	GLN88
P	ASP121
P	ASN122
P	ASN371
P	ASP522
P	ASN526
P	THR530
P	HOH954
P	HOH957
P	HOH1169

site_id	AC6
Number of Residues	6
Details	binding site for residue DMS P 606

Chain	Residue
P	ARG72
P	ARG73
P	ALA74
P	PRO76
P	PRO149
P	GLN153

site_id	AC7
Number of Residues	5
Details	binding site for residue DMS P 607

Chain	Residue
P	TYR334
P	GLN337
P	GLU338
P	LEU339
P	HOH721

site_id	AC8
Number of Residues	5
Details	binding site for residue DMS P 608

Chain	Residue
P	TYR281
P	ASN499
P	ASN503
P	HOH772
P	HOH1202

site_id	AC9
Number of Residues	7
Details	binding site for residue DMS P 609

Chain	Residue
P	ARG40
P	ASP47
P	PHE417
P	ASN499
P	PHE500
P	HOH881
P	HOH1200

site_id	AD1
Number of Residues	3
Details	binding site for residue GOL P 610

Chain	Residue
P	TYR96
P	TRP327
P	HOH701

site_id	AD2
Number of Residues	6
Details	binding site for residue DMS P 611

Chain	Residue
P	MET535
P	ILE538
P	TYR539
P	PRO540
P	HOH962
P	HOH1117

site_id	AD3
Number of Residues	8
Details	binding site for residue GOL P 612

Chain	Residue
P	VAL78
P	LEU79
P	ASP111
P	PRO165
P	VAL166
P	GLY167
P	HOH893
P	HOH934

site_id	AD4
Number of Residues	4
Details	binding site for residue DMS P 613

Chain	Residue
P	SER155
P	GLY156
P	TYR158
P	HOH1006

site_id	AD5
Number of Residues	9
Details	binding site for residue DMS P 614

Chain	Residue
P	HIS456
P	GLU543
P	GLU543
P	GLY544
P	GLY544
P	LYS547
P	LYS547
P	HOH1151
P	HOH1151

Functional Information from PROSITE/UniProt

site_id	PS00785
Number of Residues	13
Details	5_NUCLEOTIDASE_1 5'-nucleotidase signature 1. LtILHTnDvHSrL

Chain	Residue	Details
P	LEU29-LEU41

site_id	PS00786
Number of Residues	12
Details	5_NUCLEOTIDASE_2 5'-nucleotidase signature 2. YdamaLGNHEFD

Chain	Residue	Details
P	TYR110-ASP121

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22997138","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23142347","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34403084","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4H1S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7P9N","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22997138","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23142347","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34403084","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4H1S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4H1Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4H2B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4H2G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4H2I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7P9N","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22997138","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23142347","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34403084","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4H1S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4H1Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4H2B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4H2F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4H2G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4H2I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7P9N","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34403084","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7PBA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	1
Details	Site: {"description":"Transition state stabilizer","evidences":[{"source":"PubMed","id":"23142347","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	1
Details	Site: {"description":"Transition state stabilizer","evidences":[{"source":"PubMed","id":"23142347","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	1
Details	Lipidation: {"description":"GPI-anchor amidated serine","evidences":[{"source":"PubMed","id":"2129526","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22997138","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23142347","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)