8BQ7

Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with ligand TH2829

Summary for 8BQ7

• Entry DOI: 10.2210/pdb8bq7/pdb
• Descriptor: N-glycosylase/DNA lyase, ~{N}4-cyclohexyl-2~{H}-pyrazolo[3,4-d]pyrimidine-4,6-diamine, NICKEL (II) ION, ... (5 entities in total)
• Functional Keywords: ogg1, dna binding protein
• Biological source: Mus musculus (house mouse)
• Total number of polymer chains: 3
• Total formula weight: 107833.03

Authors

Scaletti, E.,Stenmark, P. (deposition date: 2022-11-19, release date: 2023-11-29, Last modification date: 2026-03-04)

• Primary citation: Hank, E.C.,D’Arcy-Evans, N.D.,Scaletti, E.R.,Benitez-Buelga, C.,Wallner, O.,Ortis, F.,Zhou, K.,Meng, L.,del Prado, A.,Calvo, P.,Almlof, I.,Wiita, E.,Nierlin, K.,Kosenina, S.,Kramer, A.,Eddershaw, A.,Kehler, M.,Long, M.,Jemth, A.S.,Dawson, H.,Stewart, J.,Dickey, A.,Astorga, M.E.,Varga, M.,Homan, E.J.,Scobie, M.,Knapp, S.,Sastre, L.,Stenmark, P.,de Vega, M.,Helleday, T.,Michel, M.; Nucleobase catalysts for the enzymatic activation of 8-oxoguanine DNA glycosylase 1; Rsc Chem Biol, 2025; DOI: 10.1039/D4CB00323C

Experimental method

X-RAY DIFFRACTION (2.6 Å)