7UAU
| The crystal structure of the K137A mutant of E. coli YGGS in complex with PLP | 分子名称: | PYRIDOXAL-5'-PHOSPHATE, Pyridoxal phosphate homeostasis protein, SULFATE ION | 著者 | Donkor, A.K, Ghatge, M.S, Musayev, F.N, Safo, M.K. | 登録日 | 2022-03-14 | 公開日 | 2022-03-23 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Characterization of the Escherichia coli pyridoxal 5'-phosphate homeostasis protein (YggS): Role of lysine residues in PLP binding and protein stability. Protein Sci., 31, 2022
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7UAX
| The crystal structure of the K36A/K38A double mutant of E. coli YGGS in complex with PLP | 分子名称: | PHOSPHATE ION, Pyridoxal phosphate homeostasis protein | 著者 | Donkor, A.K, Ghatge, M.S, Musayev, F.N, Safo, M.K. | 登録日 | 2022-03-14 | 公開日 | 2022-03-23 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | 主引用文献 | Characterization of the Escherichia coli pyridoxal 5'-phosphate homeostasis protein (YggS): Role of lysine residues in PLP binding and protein stability. Protein Sci., 31, 2022
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7UBP
| The crystal structure of the K36A/K137A double mutant of E. coli YGGS in complex with PLP | 分子名称: | PYRIDOXAL-5'-PHOSPHATE, Pyridoxal phosphate homeostasis protein, SULFATE ION | 著者 | Donkor, A.K, Ghatge, M.S, Musayev, F.N, Safo, M.K. | 登録日 | 2022-03-15 | 公開日 | 2022-03-23 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Characterization of the Escherichia coli pyridoxal 5'-phosphate homeostasis protein (YggS): Role of lysine residues in PLP binding and protein stability. Protein Sci., 31, 2022
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7UF7
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7UB4
| The crystal structure of the K36A/K38A/K233A/K234A quadruple mutant of E. coli YGGS in complex with PLP | 分子名称: | PYRIDOXAL-5'-PHOSPHATE, Pyridoxal phosphate homeostasis protein | 著者 | Donkor, A.K, Ghatge, M.S, Musayev, F.N, Safo, M.K. | 登録日 | 2022-03-14 | 公開日 | 2022-03-30 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Characterization of the Escherichia coli pyridoxal 5'-phosphate homeostasis protein (YggS): Role of lysine residues in PLP binding and protein stability. Protein Sci., 31, 2022
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7UD7
| Crystal structure of deoxygenated hemoglobin in complex with 5HMF-NO at 1.8 Angstrom | 分子名称: | Hemoglobin subunit alpha, Hemoglobin subunit beta, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Donkor, A.K, Musayev, F.N, Safo, M.K. | 登録日 | 2022-03-18 | 公開日 | 2022-03-30 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Design, Synthesis, and Antisickling Investigation of a Nitric Oxide-Releasing Prodrug of 5HMF for the Treatment of Sickle Cell Disease. Biomolecules, 12, 2022
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7UF6
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4ROM
| Deoxyhemoglobin in complex with imidazolylacryloyl derivatives | 分子名称: | 4-{2-chloro-4-[3-(1H-imidazol-2-yl)propanoyl]phenoxy}butanoic acid, Hemoglobin subunit alpha, Hemoglobin subunit beta, ... | 著者 | Omar, A.M, Mahran, M.A, Ghatge, M.N, Chowdhury, N, Bamane, F.H.A, El-Araby, M.E, Abdulmalik, O, Safo, M.K. | 登録日 | 2014-10-28 | 公開日 | 2015-05-20 | 最終更新日 | 2015-06-10 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Identification of a novel class of covalent modifiers of hemoglobin as potential antisickling agents. Org.Biomol.Chem., 13, 2015
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4ROL
| Deoxyhemoglobin in complex with imidazolylacryloyl derivatives | 分子名称: | 4-{2,3-dichloro-4-[3-(1H-imidazol-2-yl)propanoyl]phenoxy}butanoic acid, Hemoglobin subunit alpha, Hemoglobin subunit beta, ... | 著者 | Omar, A.M, Mahran, M.A, Ghatge, M.N, Chowdhury, N, Bamane, F.H.A, El-Araby, M.E, Abdulmalik, O, Safo, M.K. | 登録日 | 2014-10-28 | 公開日 | 2015-05-20 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Identification of a novel class of covalent modifiers of hemoglobin as potential antisickling agents. Org.Biomol.Chem., 13, 2015
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1QQW
| CRYSTAL STRUCTURE OF HUMAN ERYTHROCYTE CATALASE | 分子名称: | CATALASE, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Ko, T.P, Safo, M.K, Musayev, F.N, Wang, C, Wu, S.H, Abraham, D.J. | 登録日 | 1999-06-09 | 公開日 | 1999-06-14 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Structure of human erythrocyte catalase. Acta Crystallogr.,Sect.D, 56, 2000
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1R1X
| Crystal structure of oxy-human hemoglobin Bassett at 2.15 angstrom | 分子名称: | CARBON MONOXIDE, Hemoglobin alpha chain, Hemoglobin beta chain, ... | 著者 | Abdulmalik, O, Safo, M.K, Lerner, N.B, Ochotorena, J, Dhaikin, Y, Abraham, D.J, Asakura, T. | 登録日 | 2003-09-25 | 公開日 | 2003-10-07 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Characterization of hemoglobin bassett (alpha94Asp-->Ala), a variant with very low oxygen affinity Am.J.Hematol., 77, 2004
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1RV4
| E75L MUTANT OF RABBIT CYTOSOLIC SERINE HYDROXYMETHYLTRANSFERASE | 分子名称: | PHOSPHATE ION, PYRIDOXAL-5'-PHOSPHATE, Serine hydroxymethyltransferase, ... | 著者 | Szebenyi, D.M, Musayev, F.N, Di Salvo, M.L, Safo, M.K, Schirch, V. | 登録日 | 2003-12-12 | 公開日 | 2004-06-15 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | Serine Hydroxymethyltransferase: Role of Glu75 and Evidence that Serine Is Cleaved by a Retroaldol Mechanism. Biochemistry, 43, 2004
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1RVU
| E75Q MUTANT OF RABBIT CYTOSOLIC SERINE HYDROXYMETHYLTRANSFERASE | 分子名称: | PHOSPHATE ION, PYRIDOXAL-5'-PHOSPHATE, Serine hydroxymethyltransferase, ... | 著者 | Szebenyi, D.M, Musayev, F.N, Di Salvo, M.L, Safo, M.K, Schirch, V. | 登録日 | 2003-12-15 | 公開日 | 2004-06-15 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Serine Hydroxymethyltransferase: Role of Glu75 and Evidence that Serine Is Cleaved by a Retroaldol Mechanism. Biochemistry, 43, 2004
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1R1Y
| Crystal structure of deoxy-human hemoglobin Bassett at 1.8 angstrom | 分子名称: | Hemoglobin alpha chain, Hemoglobin beta chain, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Abdulmalik, O, Safo, M.K, Lerner, N.B, Ochotorena, J, Dhaikin, Y, Abraham, D.J, Asakura, T. | 登録日 | 2003-09-25 | 公開日 | 2003-10-07 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Characterization of hemoglobin bassett (alpha94Asp-->Ala), a variant with very low oxygen affinity Am.J.Hematol., 77, 2004
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1RVY
| E75Q MUTANT OF RABBIT CYTOSOLIC SERINE HYDROXYMETHYLTRANSFERASE, COMPLEX WITH GLYCINE | 分子名称: | N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE], PHOSPHATE ION, PYRIDOXAL-5'-PHOSPHATE, ... | 著者 | Szebenyi, D.M, Musayev, F.N, Di Salvo, M.L, Safo, M.K, Schirch, V. | 登録日 | 2003-12-15 | 公開日 | 2004-06-15 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Serine Hydroxymethyltransferase: Role of Glu75 and Evidence that Serine Is Cleaved by a Retroaldol Mechanism. Biochemistry, 43, 2004
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1RV3
| E75L MUTANT OF RABBIT CYTOSOLIC SERINE HYDROXYMETHYLTRANSFERASE, COMPLEX WITH GLYCINE | 分子名称: | GLYCINE, PHOSPHATE ION, PYRIDOXAL-5'-PHOSPHATE, ... | 著者 | Szebenyi, D.M, Musayev, F.N, di Salvo, M.L, Safo, M.K, Schirch, V. | 登録日 | 2003-12-12 | 公開日 | 2004-06-15 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Serine Hydroxymethyltransferase: Role of Glu75 and Evidence that Serine Is Cleaved by a Retroaldol Mechanism. Biochemistry, 43, 2004
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3IC2
| Crystal Structure of liganded hemoglobin in complex with a potent antisickling agent, INN-266 | 分子名称: | 4-[(5-methoxy-2-methylphenoxy)methyl]pyridine, Hemoglobin subunit alpha, Hemoglobin subunit beta, ... | 著者 | Safo, M.K, Musayev, F.N, Gandhi, A.K, Jorge, P. | 登録日 | 2009-07-17 | 公開日 | 2009-07-28 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural and in Vitro Chracterization of Pyridyl Derivatives of Benzaldehydes: Highly Potent Antisickling Agents To be Published
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3IC0
| Crystal Structure of liganded hemoglobin in complex with a potent antisickling agent, INN-298 | 分子名称: | 2-[(2-methoxy-5-methylphenoxy)methyl]pyridine, Hemoglobin subunit alpha, Hemoglobin subunit beta, ... | 著者 | Safo, M.K, Musayev, F.N, Gandhi, A.K, Jorge, P. | 登録日 | 2009-07-17 | 公開日 | 2009-07-28 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural and in Vitro Chracterization of Pridyl Derivatives of Benzaldehydes: Highly Potent Antisickling Agents To be Published
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5URC
| Design, Synthesis, Functional and Biological Evaluation of Ether and Ester Derivatives of the Antisickling Agent 5-HMF for the Treatment of Sickle Cell Disease | 分子名称: | (5-formylfuran-2-yl)methyl acetate, 5-HYDROXYMETHYL-FURFURAL, CARBON MONOXIDE, ... | 著者 | Pagare, P.P, Safo, R.S, Gazi, A. | 登録日 | 2017-02-10 | 公開日 | 2017-03-15 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Design, Synthesis, and Biological Evaluation of Ester and Ether Derivatives of Antisickling Agent 5-HMF for the Treatment of Sickle Cell Disease. Mol. Pharm., 14, 2017
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6DI4
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7UD8
| Crystal structure of carbon monoxy Hemoglobin in complex with 5HMF at 1.8 Angstrom | 分子名称: | (5-methylfuran-2-yl)methanol, Hemoglobin subunit alpha, Hemoglobin subunit beta, ... | 著者 | Donkor, A.K, Musayev, F.N, Safo, M.S. | 登録日 | 2022-03-18 | 公開日 | 2022-03-30 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Design, Synthesis, and Antisickling Investigation of a Nitric Oxide-Releasing Prodrug of 5HMF for the Treatment of Sickle Cell Disease. Biomolecules, 12, 2022
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3OO4
| R-state human hemoglobin: nitriheme modified at alpha | 分子名称: | Hemoglobin subunit alpha, Hemoglobin subunit beta, NITRITE ION, ... | 著者 | Yi, J, Thormas, L.M, Richter-Addo, G.B. | 登録日 | 2010-08-30 | 公開日 | 2011-09-07 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystallographic Trapping of Heme Loss Intermediates during the Nitrite-Induced Degradation of Human Hemoglobin. Biochemistry, 50, 2011
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3OO5
| R-state human hemoglobin: nitriheme modified | 分子名称: | Hemoglobin subunit alpha, Hemoglobin subunit beta, NITRITE ION, ... | 著者 | Yi, J, Thormas, L.M, Richter-Addo, G.B. | 登録日 | 2010-08-30 | 公開日 | 2011-09-07 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystallographic Trapping of Heme Loss Intermediates during the Nitrite-Induced Degradation of Human Hemoglobin. Biochemistry, 50, 2011
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8FDL
| Human Hemoglobin with Nitrosochloramphenicol | 分子名称: | GLYCEROL, Hemoglobin subunit alpha, Hemoglobin subunit beta, ... | 著者 | Powell, S.M, Richter-Addo, G.B, Thomas, L.M. | 登録日 | 2022-12-03 | 公開日 | 2023-07-12 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Crystal structural investigations of heme protein derivatives resulting from reactions of aryl- and alkylhydroxylamines with human hemoglobin. J.Inorg.Biochem., 246, 2023
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8FDN
| Human Hemoglobin with N-tertbutylhydroxylamine | 分子名称: | GLYCEROL, Hemoglobin subunit alpha, Hemoglobin subunit beta, ... | 著者 | Powell, S.M, Richter-Addo, G.B, Thomas, L.M. | 登録日 | 2022-12-03 | 公開日 | 2023-07-12 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structural investigations of heme protein derivatives resulting from reactions of aryl- and alkylhydroxylamines with human hemoglobin. J.Inorg.Biochem., 246, 2023
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