4ROL
Deoxyhemoglobin in complex with imidazolylacryloyl derivatives
Summary for 4ROL
Entry DOI | 10.2210/pdb4rol/pdb |
Related | 4ROM |
Descriptor | Hemoglobin subunit alpha, Hemoglobin subunit beta, PROTOPORPHYRIN IX CONTAINING FE, ... (6 entities in total) |
Functional Keywords | allosteric, sickle cell disease, hemoglobin, high-affinity, low-affinity, oxygen, oxygen carrying, oxygen transport |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 65577.67 |
Authors | Omar, A.M.,Mahran, M.A.,Ghatge, M.N.,Chowdhury, N.,Bamane, F.H.A.,El-Araby, M.E.,Abdulmalik, O.,Safo, M.K. (deposition date: 2014-10-28, release date: 2015-05-20, Last modification date: 2023-09-20) |
Primary citation | Omar, A.M.,Mahran, M.A.,Ghatge, M.S.,Chowdhury, N.,Bamane, F.H.,El-Araby, M.E.,Abdulmalik, O.,Safo, M.K. Identification of a novel class of covalent modifiers of hemoglobin as potential antisickling agents. Org.Biomol.Chem., 13:6353-6370, 2015 Cited by PubMed: 25974708DOI: 10.1039/c5ob00367a PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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