4ROM

Deoxyhemoglobin in complex with imidazolylacryloyl derivatives

Summary for 4ROM

• Entry DOI: 10.2210/pdb4rom/pdb
• Related: 4ROL
• Descriptor: Hemoglobin subunit alpha, Hemoglobin subunit beta, PROTOPORPHYRIN IX CONTAINING FE, ... (6 entities in total)
• Functional Keywords: allosteric, sickle cell disease, hemoglobin, high-affinity, low-affinity, oxygen, oxygen carrying, oxygen transport
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 65412.72

Authors

Omar, A.M.,Mahran, M.A.,Ghatge, M.N.,Chowdhury, N.,Bamane, F.H.A.,El-Araby, M.E.,Abdulmalik, O.,Safo, M.K. (deposition date: 2014-10-28, release date: 2015-05-20, Last modification date: 2015-06-10)

• Primary citation: Omar, A.M.,Mahran, M.A.,Ghatge, M.S.,Chowdhury, N.,Bamane, F.H.,El-Araby, M.E.,Abdulmalik, O.,Safo, M.K.; Identification of a novel class of covalent modifiers of hemoglobin as potential antisickling agents.; Org.Biomol.Chem., 13:6353-6370, 2015; PubMed: 25974708; DOI: 10.1039/c5ob00367a

Experimental method

X-RAY DIFFRACTION (1.9 Å)