6DI4

Rational Modification of Vanillin Derivatives to Stereospecifically Destabilize Sickle Hemoglobin Polymer Formation

Summary for 6DI4

Entry DOI	10.2210/pdb6di4/pdb
Descriptor	Hemoglobin subunit alpha, Hemoglobin subunit beta, CARBON MONOXIDE, ... (6 entities in total)
Functional Keywords	hemoglobin, relaxed state, sickle cell disease, aromatic aldehyde, antisickling, oxygen transport
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	65177.69
Authors	Pagare, P.P.,Musayev, F.N. (deposition date: 2018-05-22, release date: 2018-09-05, Last modification date: 2019-12-04)
Primary citation	Deshpande, T.M.,Pagare, P.P.,Ghatge, M.S.,Chen, Q.,Musayev, F.N.,Venitz, J.,Zhang, Y.,Abdulmalik, O.,Safo, M.K. Rational modification of vanillin derivatives to stereospecifically destabilize sickle hemoglobin polymer formation. Acta Crystallogr D Struct Biol, 74:956-964, 2018 Cited by PubMed: 30289405 DOI: 10.1107/S2059798318009919 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation