7UD7

Crystal structure of deoxygenated hemoglobin in complex with 5HMF-NO at 1.8 Angstrom

Summary for 7UD7

• Entry DOI: 10.2210/pdb7ud7/pdb
• Descriptor: Hemoglobin subunit alpha, Hemoglobin subunit beta, PROTOPORPHYRIN IX CONTAINING FE, ... (5 entities in total)
• Functional Keywords: hemoglobin, sickle cell disease, antisickling, no release, oxygen equilibrium, oxygen transport
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 65390.12

Authors

Donkor, A.K.,Musayev, F.N.,Safo, M.K. (deposition date: 2022-03-18, release date: 2022-03-30, Last modification date: 2023-10-18)

• Primary citation: Alhashimi, R.T.,Ghatge, M.S.,Donkor, A.K.,Deshpande, T.M.,Anabaraonye, N.,Alramadhani, D.,Danso-Danquah, R.,Huang, B.,Zhang, Y.,Musayev, F.N.,Abdulmalik, O.,Safo, M.K.; Design, Synthesis, and Antisickling Investigation of a Nitric Oxide-Releasing Prodrug of 5HMF for the Treatment of Sickle Cell Disease.; Biomolecules, 12:-, 2022; PubMed: 35625623; DOI: 10.3390/biom12050696

Experimental method

X-RAY DIFFRACTION (1.8 Å)