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5JMC
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BU of 5jmc by Molmil
Receptor binding domain of Botulinum neurotoxin A in complex with rat SV2C
Descriptor: Botulinum neurotoxin type A, Synaptic vesicle glycoprotein 2C
Authors:Yao, G, Zhang, S, Mahrhold, S, Lam, K, Stern, D, Bagramyan, K, Perry, K, Kalkum, M, Rummel, A, Dong, M, Jin, R.
Deposit date:2016-04-28
Release date:2016-06-15
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A.
Nat.Struct.Mol.Biol., 23, 2016
5JLV
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BU of 5jlv by Molmil
Receptor binding domain of Botulinum neurotoxin A in complex with human glycosylated SV2C
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ...
Authors:Yao, G, Zhang, S, Mahrhold, S, Lam, K, Stern, D, Bagramyan, K, Perry, K, Kalkum, M, Rummel, A, Dong, M, Jin, R.
Deposit date:2016-04-27
Release date:2016-06-15
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A.
Nat.Struct.Mol.Biol., 23, 2016
4QD2
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BU of 4qd2 by Molmil
Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex
Descriptor: CALCIUM ION, Cadherin-1, Hemagglutinin component HA17, ...
Authors:Lee, K, Zhong, X, Gu, S, Kruel, A, Dorner, M.B, Perry, K, Rummel, A, Dong, M, Jin, R.
Deposit date:2014-05-13
Release date:2014-06-25
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex.
Science, 344, 2014
3R4S
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BU of 3r4s by Molmil
Cell entry of botulinum neurotoxin type C is dependent upon interaction with two ganglioside molecules
Descriptor: Botulinum neurotoxin type C1, N-acetyl-alpha-neuraminic acid, N-acetyl-beta-neuraminic acid
Authors:Strotmeier, J, Gu, S, Jutzi, S, Mahrhold, S, Zhou, J, Pich, A, Bigalke, H, Rummel, A, Jin, R, Binz, T.
Deposit date:2011-03-17
Release date:2011-06-08
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:The biological activity of botulinum neurotoxin type C is dependent upon novel types of ganglioside binding sites.
Mol.Microbiol., 81, 2011
3R4U
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BU of 3r4u by Molmil
Cell entry of botulinum neurotoxin type C is dependent upon interaction with two ganglioside molecules
Descriptor: Botulinum neurotoxin type C1
Authors:Strotmeier, J, Gu, S, Jutzi, S, Mahrhold, S, Zhou, J, Pich, A, Bigalke, H, Rummel, A, Jin, R, Binz, T.
Deposit date:2011-03-17
Release date:2011-06-08
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The biological activity of botulinum neurotoxin type C is dependent upon novel types of ganglioside binding sites.
Mol.Microbiol., 81, 2011
2NM1
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BU of 2nm1 by Molmil
Structure of BoNT/B in complex with its protein receptor
Descriptor: Botulinum neurotoxin type B, Synaptotagmin-2
Authors:Jin, R, Rummel, A, Binz, T, Brunger, A.T.
Deposit date:2006-10-20
Release date:2006-12-19
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Botulinum neurotoxin B recognizes its protein receptor with high affinity and specificity.
Nature, 444, 2006
4OUJ
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BU of 4ouj by Molmil
Crystal structure of HA33B-Lac
Descriptor: Hemagglutinin component HA33, beta-D-galactopyranose-(1-4)-alpha-D-glucopyranose
Authors:Lee, K, Lam, K.-H, Perry, K, Rummel, A, Jin, R.
Deposit date:2014-02-17
Release date:2014-06-04
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:High-resolution crystal structure of HA33 of botulinum neurotoxin type B progenitor toxin complex.
Biochem.Biophys.Res.Commun., 446, 2014
3V0A
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BU of 3v0a by Molmil
2.7 angstrom crystal structure of BoNT/Ai in complex with NTNHA
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, BoNT/A, CALCIUM ION, ...
Authors:Gu, S, Rumpel, S, Zhou, J, Strotmeier, J, Bigalke, H, Perry, K, Shoemaker, C.B, Rummel, A, Jin, R.
Deposit date:2011-12-07
Release date:2012-03-14
Method:X-RAY DIFFRACTION (2.703 Å)
Cite:Botulinum neurotoxin is shielded by NTNHA in an interlocked complex.
Science, 335, 2012
3V0B
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BU of 3v0b by Molmil
3.9 angstrom crystal structure of BoNT/Ai in complex with NTNHA
Descriptor: BoNT/A, CALCIUM ION, NTNH, ...
Authors:Gu, S, Rumpel, S, Zhou, J, Strotmeier, J, Bigalke, H, Perry, K, Shoemaker, C.B, Rummel, A, Jin, R.
Deposit date:2011-12-07
Release date:2012-03-14
Last modified:2013-09-25
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Botulinum neurotoxin is shielded by NTNHA in an interlocked complex.
Science, 335, 2012
3V0C
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BU of 3v0c by Molmil
4.3 angstrom crystal structure of an inactive BoNT/A (E224Q/R363A/Y366F)
Descriptor: BoNT/A, ZINC ION
Authors:Gu, S, Rumpel, S, Zhou, J, Strotmeier, J, Bigalke, H, Perry, K, Shoemaker, C.B, Rummel, A, Jin, R.
Deposit date:2011-12-07
Release date:2012-03-14
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (4.3 Å)
Cite:Botulinum neurotoxin is shielded by NTNHA in an interlocked complex.
Science, 335, 2012
4LO3
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BU of 4lo3 by Molmil
HA17-HA33-LacNac
Descriptor: HA-17, HA-33, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose
Authors:Lee, K, Gu, S, Jin, L, Le, T.T, Cheng, L.W, Strotmeier, J, Kruel, A.M, Yao, G, Perry, K, Rummel, A, Jin, R.
Deposit date:2013-07-12
Release date:2013-10-30
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.249 Å)
Cite:Structure of a Bimodular Botulinum Neurotoxin Complex Provides Insights into Its Oral Toxicity.
Plos Pathog., 9, 2013
4LO5
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BU of 4lo5 by Molmil
HA70-alpha2,3-SiaLC
Descriptor: CHLORIDE ION, HA-70, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-alpha-D-glucopyranose
Authors:Lee, K, Gu, S, Jin, L, Le, T.T, Cheng, L.W, Strotmeier, J, Kruel, A.M, Yao, G, Perry, K, Rummel, A, Jin, R.
Deposit date:2013-07-12
Release date:2013-10-30
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of a Bimodular Botulinum Neurotoxin Complex Provides Insights into Its Oral Toxicity.
Plos Pathog., 9, 2013
4LO0
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BU of 4lo0 by Molmil
Apo HA17-HA33
Descriptor: HA-17, HA-33
Authors:Lee, K, Gu, S, Jin, L, Le, T.T, Cheng, L.W, Strotmeier, J, Kruel, A.M, Yao, G, Perry, K, Rummel, A, Jin, R.
Deposit date:2013-07-12
Release date:2013-10-30
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.055 Å)
Cite:Structure of a Bimodular Botulinum Neurotoxin Complex Provides Insights into Its Oral Toxicity.
Plos Pathog., 9, 2013
4LO2
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BU of 4lo2 by Molmil
HA17-HA33-Lac
Descriptor: HA-17, HA-33, beta-D-galactopyranose-(1-4)-beta-D-glucopyranose
Authors:Lee, K, Gu, S, Jin, L, Le, T.T, Cheng, L.W, Strotmeier, J, Kruel, A.M, Yao, G, Perry, K, Rummel, A, Jin, R.
Deposit date:2013-07-12
Release date:2013-10-30
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.254 Å)
Cite:Structure of a Bimodular Botulinum Neurotoxin Complex Provides Insights into Its Oral Toxicity.
Plos Pathog., 9, 2013
4LO4
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BU of 4lo4 by Molmil
Apo HA-70
Descriptor: CHLORIDE ION, HA-70
Authors:Lee, K, Gu, S, Jin, L, Le, T.T, Cheng, L.W, Strotmeier, J, Kruel, A.M, Yao, G, Perry, K, Rummel, A, Jin, R.
Deposit date:2013-07-12
Release date:2013-10-30
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.871 Å)
Cite:Structure of a Bimodular Botulinum Neurotoxin Complex Provides Insights into Its Oral Toxicity.
Plos Pathog., 9, 2013
4LO1
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BU of 4lo1 by Molmil
HA17-HA33-Gal
Descriptor: HA-17, HA-33, beta-D-galactopyranose
Authors:Lee, K, Gu, S, Jin, L, Le, T.T, Cheng, L.W, Strotmeier, J, Kruel, A.M, Yao, G, Perry, K, Rummel, A, Jin, R.
Deposit date:2013-07-12
Release date:2013-10-30
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.254 Å)
Cite:Structure of a Bimodular Botulinum Neurotoxin Complex Provides Insights into Its Oral Toxicity.
Plos Pathog., 9, 2013
4LO6
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BU of 4lo6 by Molmil
HA70-alpha2,6-SiaLC
Descriptor: CHLORIDE ION, HA-70, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose
Authors:Lee, K, Gu, S, Jin, L, Le, T.T, Cheng, L.W, Strotmeier, J, Kruel, A.M, Yao, G, Perry, K, Rummel, A, Jin, R.
Deposit date:2013-07-12
Release date:2013-10-30
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of a Bimodular Botulinum Neurotoxin Complex Provides Insights into Its Oral Toxicity.
Plos Pathog., 9, 2013
4LO7
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BU of 4lo7 by Molmil
HA70(D3)-HA17-HA33
Descriptor: HA-17, HA-33, HA-70
Authors:Lee, K, Gu, S, Jin, L, Le, T.T, Cheng, L.W, Strotmeier, J, Kruel, A.M, Yao, G, Perry, K, Rummel, A, Jin, R.
Deposit date:2013-07-12
Release date:2013-10-30
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.73 Å)
Cite:Structure of a Bimodular Botulinum Neurotoxin Complex Provides Insights into Its Oral Toxicity.
Plos Pathog., 9, 2013
4LO8
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BU of 4lo8 by Molmil
HA70(D3)-HA17
Descriptor: HA-17, HA-70
Authors:Lee, K, Gu, S, Jin, L, Le, T.T, Cheng, L.W, Strotmeier, J, Kruel, A.M, Yao, G, Perry, K, Rummel, A, Jin, R.
Deposit date:2013-07-12
Release date:2013-10-30
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of a Bimodular Botulinum Neurotoxin Complex Provides Insights into Its Oral Toxicity.
Plos Pathog., 9, 2013
5WIX
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BU of 5wix by Molmil
Crystal structure of P47 of Clostridium botulinum E1
Descriptor: p-47 protein
Authors:Lam, K, Liu, S, Qi, R, Jin, R.
Deposit date:2017-07-20
Release date:2017-10-25
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The hypothetical protein P47 of Clostridium botulinum E1 strain Beluga has a structural topology similar to bactericidal/permeability-increasing protein.
Toxicon, 147, 2018
5V38
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BU of 5v38 by Molmil
Crystal Structure of The Receptor-binding Domain of Botulinum Neurotoxin Type HA
Descriptor: ACETIC ACID, HcHA
Authors:Yao, G, Lam, K.-H, Jin, R.
Deposit date:2017-03-06
Release date:2017-03-22
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structure of the Receptor-Binding Domain of Botulinum Neurotoxin Type HA, Also Known as Type FA or H.
Toxins (Basel), 9, 2017
6MHJ
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BU of 6mhj by Molmil
Structure of BoNT mutant
Descriptor: Botulinum neurotoxin type A, PHOSPHATE ION
Authors:Lam, K, Jin, R.
Deposit date:2018-09-18
Release date:2018-12-26
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.019 Å)
Cite:A viral-fusion-peptide-like molecular switch drives membrane insertion of botulinum neurotoxin A1.
Nat Commun, 9, 2018
7UIB
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BU of 7uib by Molmil
Crystal structure of BoNT/E receptor binding domain in complex with SV2, VHH, and sialic acid
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-acetyl-beta-neuraminic acid, ...
Authors:Liu, Z, Jin, R, Chen, P.
Deposit date:2022-03-29
Release date:2023-04-05
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.77 Å)
Cite:Structural basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2.
Nat Commun, 14, 2023
8FBD
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BU of 8fbd by Molmil
Crystal structure of OrfX1-OrfX3 complex from Clostridium botulinum E1
Descriptor: ACETATE ION, Neurotoxin complex component Orf-X1, Neurotoxin complex component Orf-X3
Authors:Liu, S, Gao, L.
Deposit date:2022-11-29
Release date:2022-12-21
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structures of OrfX1, OrfX2 and the OrfX1-OrfX3 complex from the orfX gene cluster of botulinum neurotoxin E1.
Febs Lett., 597, 2023
8FBE
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BU of 8fbe by Molmil
Crystal structure of OrfX1 from Clostridium botulinum E1
Descriptor: Neurotoxin complex component Orf-X1
Authors:Liu, S, Gao, L.
Deposit date:2022-11-29
Release date:2022-12-21
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Crystal structures of OrfX1, OrfX2 and the OrfX1-OrfX3 complex from the orfX gene cluster of botulinum neurotoxin E1.
Febs Lett., 597, 2023

 

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