3R4S

Cell entry of botulinum neurotoxin type C is dependent upon interaction with two ganglioside molecules

Summary for 3R4S

Related3R4U
DescriptorBotulinum neurotoxin type C1, 5-N-ACETYL-BETA-D-NEURAMINIC ACID, O-SIALIC ACID, ... (4 entities in total)
Functional Keywordsbotulinum toxins, gangliosides, hydrolase
Biological sourceClostridium botulinum
Cellular locationBotulinum neurotoxin C1 light chain: Secreted. Botulinum neurotoxin C1 heavy chain: Secreted P18640
Total number of polymer chains2
Total molecular weight104057.78
Authors
Strotmeier, J.,Gu, S.,Jutzi, S.,Mahrhold, S.,Zhou, J.,Pich, A.,Bigalke, H.,Rummel, A.,Jin, R.,Binz, T. (deposition date: 2011-03-17, release date: 2011-06-08, Last modification date: 2018-03-07)
Primary citation
Strotmeier, J.,Gu, S.,Jutzi, S.,Mahrhold, S.,Zhou, J.,Pich, A.,Eichner, T.,Bigalke, H.,Rummel, A.,Jin, R.,Binz, T.
The biological activity of botulinum neurotoxin type C is dependent upon novel types of ganglioside binding sites.
Mol.Microbiol., 81:143-156, 2011
PubMed: 21542861 (PDB entries with the same primary citation)
DOI: 10.1111/j.1365-2958.2011.07682.x
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.15 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.200600.8%2.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 3r4s
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More Biological unit images

Molmil generated image of 3r4s
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Molmil generated image of 3r4s
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Molmil generated image of 3r4s
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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (3r4s.pdb1.gz [82.12 KB])
Coordinate files for Biological unit (3r4s.pdb2.gz [82.07 KB])