3R4S

Cell entry of botulinum neurotoxin type C is dependent upon interaction with two ganglioside molecules

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Functional Information from GO Data

ChainGOidnamespacecontents
A0005576cellular_componentextracellular region
A0035594molecular_functionganglioside binding
A0004222molecular_functionmetalloendopeptidase activity
A0008320molecular_functionprotein transmembrane transporter activity
A0090729molecular_functiontoxin activity
A0008270molecular_functionzinc ion binding
A0033619biological_processmembrane protein proteolysis
A0045955biological_processnegative regulation of calcium ion-dependent exocytosis
A0046929biological_processnegative regulation of neurotransmitter secretion
A0009405biological_processpathogenesis
B0005576cellular_componentextracellular region
B0035594molecular_functionganglioside binding
B0004222molecular_functionmetalloendopeptidase activity
B0008320molecular_functionprotein transmembrane transporter activity
B0090729molecular_functiontoxin activity
B0008270molecular_functionzinc ion binding
B0033619biological_processmembrane protein proteolysis
B0045955biological_processnegative regulation of calcium ion-dependent exocytosis
B0046929biological_processnegative regulation of neurotransmitter secretion
B0009405biological_processpathogenesis
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Functional Information from PDB Data

site_idNumber of ResiduesDetails
AC110BINDING SITE FOR RESIDUE SLB B 6875
ChainResidue
BHOH309
BHOH504
BHOH722
BHOH775
BTYR1125
BALA1126
BASN1127
BSER1128
BARG1129
BTYR1146

AC210BINDING SITE FOR RESIDUE SLB A 6875
ChainResidue
AHOH181
AHOH662
AHOH730
ATYR1125
AALA1126
AASN1127
ASER1128
AARG1129
ATYR1146
ATYR1179

AC310BINDING SITE FOR RESIDUE SIA B 6859
ChainResidue
BHOH163
BHOH370
BHOH484
BTYR1169
BASP1171
BASN1180
BGLN1206
BTHR1207
BLYS1208
BILE1210

AC410BINDING SITE FOR RESIDUE SIA A 6859
ChainResidue
AHOH206
AHOH305
AHOH339
AHOH576
ATYR1169
AASP1171
AASN1180
AGLN1206
ATHR1207
ALYS1208

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Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
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Functional Information from PROSITE/UniProt

site_idNumber of ResiduesDetails
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Functional Information from SwissProt/UniProt

site_idNumber of ResiduesDetails
SWS_FT_FI11{ECO:0000255|PROSITE-ProRule:PRU10095}.
ChainResidueDetails
ANA*

SWS_FT_FI22Zinc; catalytic. {ECO:0000255|PROSITE- ProRule:PRU10095}
ChainResidueDetails
ANA*
ANA*

SWS_FT_FI31{ECO:0000255|PROSITE-ProRule:PRU10095}.
ChainResidueDetails
BNA*

SWS_FT_FI42Zinc; catalytic. {ECO:0000255|PROSITE- ProRule:PRU10095}
ChainResidueDetails
BNA*
BNA*

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Catalytic Information from CSA

site_idNumber of ResiduesDetails