3R4S
Cell entry of botulinum neurotoxin type C is dependent upon interaction with two ganglioside molecules
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Botulinum neurotoxin type C1 | polymer | 443 | 51410.3 | 2 | UniProt (P18640) | Clostridium botulinum | BoNT/C1, Bontoxilysin-C1, Botulinum neurotoxin C1 heavy chain |
| 2 | C, E (A, B) | N-acetyl-beta-neuraminic acid | non-polymer | 309.3 | 2 | Chemie (SLB) PubChem (16758151) PubChem (17757261) PubChem (20843074) PubChem (1807423) PubChem (906) PubChem (8565) PubChem (24801877) PubChem (26470719) PubChem (26470725) PubChem (36690637) PubChem (40429907) PubChem (40477531) PubChem (40785048) PubChem (42553514) PubChem (42553516) PubChem (42553518) PubChem (42553520) PubChem (44120039) PubChem (44338934) PubChem (45933901) PubChem (49819355) PubChem (26470722) PubChem (163606) PubChem (57859521) PubChem (58341444) PubChem (58545373) PubChem (439197) PubChem (58964108) PubChem (59331136) PubChem (67604154) PubChem (68257483) PubChem (68260278) PubChem (68315779) PubChem (444885) PubChem (445063) PubChem (445727) PubChem (70643192) PubChem (70666785) PubChem (70979316) PubChem (71299579) PubChem (71650744) PubChem (58392620) PubChem (1549084) PubChem (89869240) PubChem (89869500) PubChem (89869501) PubChem (89869502) PubChem (656387) PubChem (5702294) PubChem (6560217) PubChem (7048542) PubChem (5748928) PubChem (7173829) PubChem (92354618) PubChem (6398955) PubChem (93959067) PubChem (94016791) PubChem (95566316) PubChem (96562275) PubChem (102004932) PubChem (6992095) PubChem (102145501) PubChem (117937408) PubChem (7059665) PubChem (7092680) PubChem (7092682) PubChem (7173826) PubChem (7569151) PubChem (122374560) PubChem (124040735) PubChem (10936453) PubChem (124490223) PubChem (11370291) PubChem (11876108) PubChem (11908614) PubChem (145832226) PubChem (13657114) PubChem (15560314) PubChem (15560306) PubChem (15560307) PubChem (15560308) PubChem (15560310) PubChem (15560312) PubChem (15560313) PubChem (15560315) PubChem (15560316) PubChem (15560317) PubChem (168364984) PubChem (126963458) PubChem (129672250) PubChem (130267610) PubChem (130330497) PubChem (132187635) PubChem (133688898) PubChem (134689626) PubChem (134973249) PubChem (135053795) PubChem (135055138) PubChem (139256539) PubChem (155021572) PubChem (156051160) PubChem (160911533) PubChem (160911534) PubChem (164670778) PubChem (166985445) PubChem (168314628) PubChem (168358112) PubChem (168358795) PubChem (168369824) PubChem (168370581) PubChem (168373659) PubChem (168375635) PubChem (173875492) PubChem (173910549) PubChem (173918449) | |||
| 3 | D, F (A, B) | N-acetyl-alpha-neuraminic acid | non-polymer | 309.3 | 2 | Chemie (SIA) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 870 | Chemie (HOH) |
Sequence modifications
A, B: 867 - 1291 (UniProt: P18640)
| PDB | External Database | Details |
|---|---|---|
| Met 861 | - | expression tag |
| Arg 862 | - | expression tag |
| Gly 863 | - | expression tag |
| Ser 864 | - | expression tag |
| Met 865 | - | expression tag |
| Ala 866 | - | expression tag |
| Pro 1292 | - | expression tag |
| Gly 1293 | - | expression tag |
| Ser 1294 | - | expression tag |
| Ala 1295 | - | expression tag |
| Trp 1296 | - | expression tag |
| Ser 1297 | - | expression tag |
| His 1298 | - | expression tag |
| Pro 1299 | - | expression tag |
| Gln 1300 | - | expression tag |
| Phe 1301 | - | expression tag |
| Glu 1302 | - | expression tag |
| Lys 1303 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 102820.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1237.1 | |
| All* | Total formula weight | 104057.8 |
