3R4U

Cell entry of botulinum neurotoxin type C is dependent upon interaction with two ganglioside molecules

Summary for 3R4U

• Entry DOI: 10.2210/pdb3r4u/pdb
• Related: 3R4S
• Descriptor: Botulinum neurotoxin type C1 (2 entities in total)
• Functional Keywords: botulinum toxins, gangliosides, hydrolase
• Biological source: Clostridium botulinum
• Cellular location: Botulinum neurotoxin C1 light chain: Secreted. Botulinum neurotoxin C1 heavy chain: Secreted: P18640
• Total number of polymer chains: 2
• Total formula weight: 102820.70

Authors

Strotmeier, J.,Gu, S.,Jutzi, S.,Mahrhold, S.,Zhou, J.,Pich, A.,Bigalke, H.,Rummel, A.,Jin, R.,Binz, T. (deposition date: 2011-03-17, release date: 2011-06-08, Last modification date: 2024-02-21)

• Primary citation: Strotmeier, J.,Gu, S.,Jutzi, S.,Mahrhold, S.,Zhou, J.,Pich, A.,Eichner, T.,Bigalke, H.,Rummel, A.,Jin, R.,Binz, T.; The biological activity of botulinum neurotoxin type C is dependent upon novel types of ganglioside binding sites.; Mol.Microbiol., 81:143-156, 2011; PubMed: 21542861; DOI: 10.1111/j.1365-2958.2011.07682.x

Experimental method

X-RAY DIFFRACTION (2.2 Å)