3R4U

Cell entry of botulinum neurotoxin type C is dependent upon interaction with two ganglioside molecules

Summary for 3R4U

Related3R4S
DescriptorBotulinum neurotoxin type C1 (2 entities in total)
Functional Keywordsbotulinum toxins, gangliosides, hydrolase
Biological sourceClostridium botulinum
Cellular locationBotulinum neurotoxin C1 light chain: Secreted. Botulinum neurotoxin C1 heavy chain: Secreted P18640
Total number of polymer chains2
Total molecular weight102820.7
Authors
Strotmeier, J.,Gu, S.,Jutzi, S.,Mahrhold, S.,Zhou, J.,Pich, A.,Bigalke, H.,Rummel, A.,Jin, R.,Binz, T. (deposition date: 2011-03-17, release date: 2011-06-08, Last modification date: 2018-02-14)
Primary citation
Strotmeier, J.,Gu, S.,Jutzi, S.,Mahrhold, S.,Zhou, J.,Pich, A.,Eichner, T.,Bigalke, H.,Rummel, A.,Jin, R.,Binz, T.
The biological activity of botulinum neurotoxin type C is dependent upon novel types of ganglioside binding sites.
Mol.Microbiol., 81:143-156, 2011
PubMed: 21542861 (PDB entries with the same primary citation)
DOI: 10.1111/j.1365-2958.2011.07682.x
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.2 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.205400.9%1.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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