3R4U
Cell entry of botulinum neurotoxin type C is dependent upon interaction with two ganglioside molecules
Functional Information from GO Data
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 394 |
| Details | Region: {"description":"C-terminus of receptor binding domain (C-RBD)","evidences":[{"source":"UniProtKB","id":"P0DPI0","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 28 |
| Details | Region: {"description":"Ganglioside-binding loop","evidences":[{"source":"PubMed","id":"20731382","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"21542861","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Motif: {"description":"Host ganglioside-binding motif","evidences":[{"source":"UniProtKB","id":"P10844","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"19650874","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 10 |
| Details | Binding site: {"description":"GBP2 binding site","evidences":[{"source":"PubMed","id":"23027864","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | Binding site: {"description":"Sia-1 binding site","evidences":[{"source":"PubMed","id":"21542861","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3R4S","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
