8DYV
 
 | | Structure of human cytoplasmic dynein-1 bound to one Lis1 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cytoplasmic dynein 1 heavy chain 1, ... | | Authors: | Reimer, J.M, DeSantis, M, Reck-Peterson, S.L, Leschziner, A.E. | | Deposit date: | 2022-08-05 | | Release date: | 2023-02-01 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.97 Å) | | Cite: | Structures of human dynein in complex with the lissencephaly 1 protein, LIS1.
Elife, 12, 2023
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8DYU
 | | Structure of human cytoplasmic dynein-1 bound to two Lis1 proteins | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cytoplasmic dynein 1 heavy chain 1, ... | | Authors: | Reimer, J.M, DeSantis, M, Reck-Peterson, S.L, Leschziner, A.E. | | Deposit date: | 2022-08-05 | | Release date: | 2023-02-01 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Structures of human dynein in complex with the lissencephaly 1 protein, LIS1.
Elife, 12, 2023
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5VLJ
 | | Cryo-EM structure of yeast cytoplasmic dynein with Walker B mutation at AAA3 in presence of ATP-VO4 | | Descriptor: | Dynein heavy chain, cytoplasmic, Nuclear distribution protein PAC1 | | Authors: | Cianfrocco, M.A, DeSantis, M.E, Htet, Z.M, Tran, P.T, Reck-Peterson, S.L, Leschziner, A.E. | | Deposit date: | 2017-04-25 | | Release date: | 2017-09-06 | | Last modified: | 2020-01-01 | | Method: | ELECTRON MICROSCOPY (10.5 Å) | | Cite: | Lis1 Has Two Opposing Modes of Regulating Cytoplasmic Dynein.
Cell, 170, 2017
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5VH9
 | | Cryo-EM structure of yeast cytoplasmic dynein-1 with Lis1 and ATP | | Descriptor: | Dynein heavy chain, cytoplasmic, Nuclear distribution protein PAC1 | | Authors: | Cianfrocco, M.A, DeSantis, M.E, Htet, Z.M, Tran, P.T, Reck-Peterson, S.L, Leschziner, A.E. | | Deposit date: | 2017-04-12 | | Release date: | 2017-09-06 | | Last modified: | 2020-01-01 | | Method: | ELECTRON MICROSCOPY (7.7 Å) | | Cite: | Lis1 Has Two Opposing Modes of Regulating Cytoplasmic Dynein.
Cell, 170, 2017
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3J1T
 | | High affinity dynein microtubule binding domain - tubulin complex | | Descriptor: | Cytoplasmic dynein 1 heavy chain 1, seryl t-RNA synthetase chimera, Tubulin alpha-1B chain, ... | | Authors: | Redwine, W.B, Hernandez-Lopez, R, Zou, S, Huang, J, Reck-Peterson, S.L, Leschziner, A.E. | | Deposit date: | 2012-06-25 | | Release date: | 2012-09-26 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (9.7 Å) | | Cite: | Structural basis for microtubule binding and release by dynein.
Science, 337, 2012
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3J1U
 | | Low affinity dynein microtubule binding domain - tubulin complex | | Descriptor: | Cytoplasmic dynein 1 heavy chain 1, seryl t-RNA synthetase chimera, Tubulin alpha-1B chain, ... | | Authors: | Redwine, W.B, Hernandez-Lopez, R, Zou, S, Huang, J, Reck-Peterson, S.L, Leschziner, A.E. | | Deposit date: | 2012-06-25 | | Release date: | 2012-09-26 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (9.7 Å) | | Cite: | Structural basis for microtubule binding and release by dynein.
Science, 337, 2012
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6VP7
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7MGM
 | | Structure of yeast cytoplasmic dynein with AAA3 Walker B mutation bound to Lis1 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Lahiri, I, Reimer, J.M, Leschziner, A.E. | | Deposit date: | 2021-04-12 | | Release date: | 2022-01-19 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural basis for cytoplasmic dynein-1 regulation by Lis1.
Elife, 11, 2022
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7THZ
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7THY
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6VNO
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6VP8
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6VP6
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8DZZ
 | | Cryo-EM structure of chi dynein bound to Lis1 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Dynein heavy chain, ... | | Authors: | Reimer, J.M, Lahiri, I, Leschziner, A.E. | | Deposit date: | 2022-08-08 | | Release date: | 2023-08-30 | | Last modified: | 2023-09-27 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Lis1 relieves cytoplasmic dynein-1 autoinhibition by acting as a molecular wedge.
Nat.Struct.Mol.Biol., 30, 2023
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8E06
 | | Symmetry expansion of dimeric LRRK1 | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Leucine-rich repeat serine/threonine-protein kinase 1 | | Authors: | Reimer, J.M, Lin, Y.X, Leschziner, A.E. | | Deposit date: | 2022-08-08 | | Release date: | 2023-08-30 | | Last modified: | 2023-11-29 | | Method: | ELECTRON MICROSCOPY (4.3 Å) | | Cite: | Structure of LRRK1 and mechanisms of autoinhibition and activation.
Nat.Struct.Mol.Biol., 30, 2023
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8E04
 | | Structure of monomeric LRRK1 | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Leucine-rich repeat serine/threonine-protein kinase 1 | | Authors: | Reimer, J.M, Mathea, S, Chatterjee, D, Knapp, S, Leschziner, A.E. | | Deposit date: | 2022-08-08 | | Release date: | 2023-08-30 | | Last modified: | 2023-11-29 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Structure of LRRK1 and mechanisms of autoinhibition and activation.
Nat.Struct.Mol.Biol., 30, 2023
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8E00
 | | Symmetry expansion of yeast cytoplasmic dynein-1 bound to Lis1 in the chi conformation. | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Dynein heavy chain, ... | | Authors: | Reimer, J.M, Lahiri, I, Leschziner, A.E. | | Deposit date: | 2022-08-08 | | Release date: | 2023-08-30 | | Last modified: | 2023-09-27 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Lis1 relieves cytoplasmic dynein-1 autoinhibition by acting as a molecular wedge.
Nat.Struct.Mol.Biol., 30, 2023
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8E05
 | | Structure of dimeric LRRK1 | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Leucine-rich repeat serine/threonine-protein kinase 1 | | Authors: | Reimer, J.M, Lin, Y.X, Leschziner, A.E. | | Deposit date: | 2022-08-08 | | Release date: | 2023-08-30 | | Last modified: | 2023-11-29 | | Method: | ELECTRON MICROSCOPY (4.6 Å) | | Cite: | Structure of LRRK1 and mechanisms of autoinhibition and activation.
Nat.Struct.Mol.Biol., 30, 2023
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