6VNO

Cryo-EM structure of the C-terminal half of the Parkinson's Disease-linked protein Leucine Rich Repeat Kinase 2 (LRRK2)

Summary for 6VNO

Entry DOI	10.2210/pdb6vno/pdb
EMDB information	21250
Descriptor	Leucine-rich repeat serine/threonine-protein kinase 2, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION (3 entities in total)
Functional Keywords	kinase, gtpase, signaling protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	137411.11
Authors	Leschziner, A.,Deniston, C.,Lahiri, I. (deposition date: 2020-01-29, release date: 2020-08-26, Last modification date: 2020-12-23)
Primary citation	Deniston, C.K.,Salogiannis, J.,Mathea, S.,Snead, D.M.,Lahiri, I.,Matyszewski, M.,Donosa, O.,Watanabe, R.,Bohning, J.,Shiau, A.K.,Knapp, S.,Villa, E.,Reck-Peterson, S.L.,Leschziner, A.E. Structure of LRRK2 in Parkinson's disease and model for microtubule interaction. Nature, 588:344-349, 2020 Cited by PubMed: 32814344 DOI: 10.1038/s41586-020-2673-2 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.5 Å)

Structure validation