6VNO

Cryo-EM structure of the C-terminal half of the Parkinson's Disease-linked protein Leucine Rich Repeat Kinase 2 (LRRK2)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0005525	molecular_function	GTP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue GDP A 2601

Chain	Residue
A	TPO1343
A	ASN1489
A	ALA1490
A	THR1491
A	MG2602
A	GLY1344
A	SER1345
A	GLY1346
A	LYS1347
A	THR1348
A	THR1349
A	HIS1453
A	ASP1455

---

site_id	AC2
Number of Residues	2
Details	binding site for residue MG A 2602

Chain	Residue
A	THR1348
A	GDP2601

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	22
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGDGSFGSVYrAayegee............VAVK

Chain	Residue	Details
A	LEU1885-LYS1906

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiYrDLKphNVLL

Chain	Residue	Details
A	ILE1990-LEU2002

---

site_id	PS00626
Number of Residues	11
Details	RCC1_2 Regulator of chromosome condensation (RCC1) signature 2. IGTGgGHILLL

Chain	Residue	Details
A	ILE2427-LEU2437

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	Repeat: {"description":"WD 2","evidences":[{"source":"PubMed","id":"38127736","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8FO2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FO8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FO9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	44
Details	Repeat: {"description":"WD 5","evidences":[{"source":"PubMed","id":"38127736","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8FO2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FO8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FO9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"38127736","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8FO9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"38127736","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8FO8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FO9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"38127736","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8FO2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FO8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	26
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00758","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"28202711","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---