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6TIW
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BU of 6tiw by Molmil
Human kinesin-5 motor domain in the GSK state bound to microtubules (Conformation 2)
Descriptor: 6-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1~{H}-quinolin-2-one, Kinesin-like protein KIF11, MAGNESIUM ION, ...
Authors:Pena, A, Sweeney, A, Cook, A.D, Moores, C.A, Topf, M.
Deposit date:2019-11-22
Release date:2020-03-04
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structure of Microtubule-Trapped Human Kinesin-5 and Its Mechanism of Inhibition Revealed Using Cryoelectron Microscopy.
Structure, 28, 2020
6TA3
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BU of 6ta3 by Molmil
Human kinesin-5 motor domain in the GSK-1 state bound to microtubules (Conformation 1)
Descriptor: 6-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1~{H}-quinolin-2-one, Kinesin-like protein KIF11, MAGNESIUM ION, ...
Authors:Pena, A, Sweeney, A, Cook, A.D, Moores, C.A, Topf, M.
Deposit date:2019-10-29
Release date:2020-04-22
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structure of Microtubule-Trapped Human Kinesin-5 and Its Mechanism of Inhibition Revealed Using Cryoelectron Microscopy.
Structure, 28, 2020
6NIJ
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BU of 6nij by Molmil
PGT145 Fab in complex with full length AMC011 HIV-1 Env
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, AMC011 Glycoprotein 120, ...
Authors:Cottrell, C.A, Torrents de la Pena, A, Rantalainen, K, Torres, J.L, Ward, A.B.
Deposit date:2018-12-29
Release date:2019-07-31
Last modified:2023-04-05
Method:ELECTRON MICROSCOPY (5.7 Å)
Cite:Similarities and differences between native HIV-1 envelope glycoprotein trimers and stabilized soluble trimer mimetics.
Plos Pathog., 15, 2019
5WDU
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BU of 5wdu by Molmil
HIV-1 Env BG505 SOSIP.664 H72C-H564C trimer in complex with bNAbs PGT122 Fab, 35O22 Fab and NIH45-46 scFv
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp160, ...
Authors:Julien, J.-P, Torrents de la Pena, A, Sanders, R.W, Wilson, I.A.
Deposit date:2017-07-06
Release date:2018-04-04
Last modified:2022-11-30
Method:X-RAY DIFFRACTION (7 Å)
Cite:Improving the Immunogenicity of Native-like HIV-1 Envelope Trimers by Hyperstabilization.
Cell Rep, 20, 2017
7SCN
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BU of 7scn by Molmil
Structure of H1 NC99 influenza hemagglutinin bound to Fab 310-63E6
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 310-63E6 Fab, Heavy Chain, ...
Authors:Ward, A, Torrents de la Pena, A.
Deposit date:2021-09-28
Release date:2022-08-24
Last modified:2022-09-28
Method:ELECTRON MICROSCOPY (3.02 Å)
Cite:Allelic polymorphism controls autoreactivity and vaccine elicitation of human broadly neutralizing antibodies against influenza virus.
Immunity, 55, 2022
7SCO
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BU of 7sco by Molmil
Structure of H1 influenza hemagglutinin bound to Fab 310-39G10
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 310-39G10 Fab, ...
Authors:Torrents de la Pena, A, Ward, A.B.
Deposit date:2021-09-28
Release date:2022-08-24
Last modified:2022-09-28
Method:ELECTRON MICROSCOPY (3.37 Å)
Cite:Allelic polymorphism controls autoreactivity and vaccine elicitation of human broadly neutralizing antibodies against influenza virus.
Immunity, 55, 2022
7T6X
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BU of 7t6x by Molmil
Cryo-EM structure of full-length hepatitis C virus E1E2 glycoprotein in complex with AR4A, AT12009, and IGH505 Fabs
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, AR4A Fab, ...
Authors:Torrents de la Pena, A, Ward, A.B, Eshun-Wilson, L, Lander, G.C.
Deposit date:2021-12-14
Release date:2022-11-02
Method:ELECTRON MICROSCOPY (3.83 Å)
Cite:Structure of the hepatitis C virus E1E2 glycoprotein complex.
Science, 378, 2022
7JSV
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BU of 7jsv by Molmil
Cryo-EM structure of conjugative pili from carbapenem-resistant Klebsiella pneumoniae
Descriptor: 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, Pilin
Authors:Zheng, W, Pena, A, Frankel, G, Egelman, E.H.
Deposit date:2020-08-16
Release date:2020-09-02
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Cryoelectron-Microscopic Structure of the pKpQIL Conjugative Pili from Carbapenem-Resistant Klebsiella pneumoniae.
Structure, 28, 2020
6ZPH
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BU of 6zph by Molmil
Kinesin binding protein complexed with Kif15 motor domain
Descriptor: ADENOSINE-5'-DIPHOSPHATE, KIF-binding protein, Kinesin-like protein KIF15, ...
Authors:Atherton, J, Hummel, J.J.A, Olieric, N, Locke, J, Pena, A, Rosenfeld, S.S, Steinmetz, M.O, Hoogenraad, C.C, Moores, C.A.
Deposit date:2020-07-08
Release date:2020-12-30
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (6.9 Å)
Cite:The mechanism of kinesin inhibition by kinesin-binding protein.
Elife, 9, 2020
6ZPI
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BU of 6zpi by Molmil
Microtubule complexed with Kif15 motor domain. Symmetrised asymmetric unit
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein KIF15, ...
Authors:Atherton, J, Hummel, J.J.A, Olieric, N, Locke, J, Pena, A, Rosenfeld, S.S, Steinmetz, M.O, Hoogenraad, C.C, Moores, C.A.
Deposit date:2020-07-08
Release date:2020-12-30
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:The mechanism of kinesin inhibition by kinesin-binding protein.
Elife, 9, 2020
6ZPG
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BU of 6zpg by Molmil
Kinesin binding protein (KBP)
Descriptor: KIF-binding protein
Authors:Atherton, J, Hummel, J.J.A, Olieric, N, Locke, J, Pena, A, Rosenfeld, S.S, Steinmetz, M.O, Hoogenraad, C.C, Moores, C.A.
Deposit date:2020-07-08
Release date:2020-12-30
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:The mechanism of kinesin inhibition by kinesin-binding protein.
Elife, 9, 2020
6TA4
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BU of 6ta4 by Molmil
Human kinesin-5 motor domain in the AMPPNP state bound to microtubules
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein KIF11, MAGNESIUM ION, ...
Authors:Pena, A.P, Sweeney, A, Cook, A.D, Moores, C.A, Topf, M.
Deposit date:2019-10-29
Release date:2020-03-04
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (6.1 Å)
Cite:Structure of Microtubule-Trapped Human Kinesin-5 and Its Mechanism of Inhibition Revealed Using Cryoelectron Microscopy.
Structure, 28, 2020
8TGO
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BU of 8tgo by Molmil
Crystal structure of the BG505 triple tandem trimer gp140 HIV-1 Env in complex with PGT124 and 35O22
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 35O22 scFv, ...
Authors:Xian, Y, Yuan, M, Wilson, I.A.
Deposit date:2023-07-12
Release date:2024-04-17
Method:X-RAY DIFFRACTION (5.75 Å)
Cite:Triple tandem trimer immunogens for HIV-1 and influenza nucleic acid-based vaccines.
Npj Vaccines, 9, 2024
5AWN
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BU of 5awn by Molmil
Crystal structure of Human anti-HIV-1 broadly neutralizing antibody 3BC176 Fab
Descriptor: Heavy chain of 3BC176 Fab, Light chain of 3BC176 Fab
Authors:Lee, J.H, Wilson, I.A, Ward, A.B.
Deposit date:2015-07-06
Release date:2015-11-11
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.887 Å)
Cite:Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike.
Nat Commun, 6, 2015
7ZLK
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BU of 7zlk by Molmil
AMC009 SOSIPv5.2 in complex with Fabs ACS101 and ACS124
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACS114 heavy chain, ...
Authors:van Schooten, J, Ozorowski, G, Ward, A.
Deposit date:2022-04-15
Release date:2022-09-21
Last modified:2022-11-30
Method:ELECTRON MICROSCOPY (3.99 Å)
Cite:Complementary antibody lineages achieve neutralization breadth in an HIV-1 infected elite neutralizer.
Plos Pathog., 18, 2022
8D7Y
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BU of 8d7y by Molmil
Cereblon-DDB1 in the Apo form with DDB1 in the twisted conformation
Descriptor: DNA damage-binding protein 1, Protein cereblon, ZINC ION
Authors:Watson, E.R, Lander, G.C.
Deposit date:2022-06-07
Release date:2022-07-20
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Molecular glue CELMoD compounds are regulators of cereblon conformation.
Science, 378, 2022
8D7X
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BU of 8d7x by Molmil
Cereblon~DDB1 in the Apo form with DDB1 in the hinged conformation
Descriptor: DNA damage-binding protein 1, Protein cereblon, ZINC ION
Authors:Watson, E.R, Lander, G.C.
Deposit date:2022-06-07
Release date:2022-07-20
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Molecular glue CELMoD compounds are regulators of cereblon conformation.
Science, 378, 2022
6S8M
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BU of 6s8m by Molmil
S. pombe microtubule decorated with Cut7 motor domain in the AMPPNP state
Descriptor: 7,11-DIHYDROXY-8,8,10,12,16-PENTAMETHYL-3-[1-METHYL-2-(2-METHYL-THIAZOL-4-YL)VINYL]-4,17-DIOXABICYCLO[14.1.0]HEPTADECANE-5,9-DIONE, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Moores, C.A, von Loeffelholz, O.
Deposit date:2019-07-10
Release date:2019-08-21
Last modified:2023-09-20
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Cryo-EM Structure (4.5- angstrom ) of Yeast Kinesin-5-Microtubule Complex Reveals a Distinct Binding Footprint and Mechanism of Drug Resistance.
J.Mol.Biol., 431, 2019
7U5G
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BU of 7u5g by Molmil
ACS122 Fab
Descriptor: ACS122 Fab Heavy chain, ACS122 Fab Light chain
Authors:Farokhi, E, Stanfield, R.L, Wilson, I.A.
Deposit date:2022-03-02
Release date:2022-11-02
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Complementary antibody lineages achieve neutralization breadth in an HIV-1 infected elite neutralizer.
Plos Pathog., 18, 2022
5CCK
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BU of 5cck by Molmil
Crystal structure of Human anti-HIV-1 broadly neutralizing antibody 3BC315 Fab
Descriptor: 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, Antibody 3BC315 Fab heavy chain, Antibody 3BC315 Fab light chain
Authors:Lee, J.H, Ward, A.B, Wilson, I.A.
Deposit date:2015-07-02
Release date:2015-10-07
Last modified:2019-12-11
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike.
Nat Commun, 6, 2015
6VO3
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BU of 6vo3 by Molmil
AMC009 SOSIP.v4.2 in complex with PGV04 Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, AMC009 SOSIP.v4.2 envelope glycoprotein gp120, ...
Authors:Cottrell, C.A, de Val, N, Ward, A.B.
Deposit date:2020-01-29
Release date:2020-09-23
Last modified:2020-12-09
Method:ELECTRON MICROSCOPY (4.25 Å)
Cite:Neutralizing Antibody Responses Induced by HIV-1 Envelope Glycoprotein SOSIP Trimers Derived from Elite Neutralizers.
J.Virol., 94, 2020
7L8A
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BU of 7l8a by Molmil
BG505 SOSIP MD39 in complex with the polyclonal Fab pAbC-1 from animal Rh.33104 (Wk26 time point)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BG505 SOSIP MD39 - gp120, ...
Authors:Antanasijevic, A, Sewall, L.M, Torrents de la Pena, A, Ward, A.B.
Deposit date:2020-12-31
Release date:2021-08-04
Last modified:2021-08-25
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM.
Nat Commun, 12, 2021
7SN9
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BU of 7sn9 by Molmil
Cryo-EM structure of the Sinorhizobium meliloti flagellar filament
Descriptor: Flagellin A
Authors:Kreutzberger, M.A.B, Scharf, B.E, Egelman, E.H.
Deposit date:2021-10-27
Release date:2022-03-16
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Flagellin outer domain dimerization modulates motility in pathogenic and soil bacteria from viscous environments.
Nat Commun, 13, 2022
7SN4
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BU of 7sn4 by Molmil
Cryo-EM structure of the enterohemorrhagic E. coli O157:H7 flagellar filament
Descriptor: Flagellin
Authors:Kreutzberger, M.A.B, Wang, F, Egelman, E.H.
Deposit date:2021-10-27
Release date:2022-03-16
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Flagellin outer domain dimerization modulates motility in pathogenic and soil bacteria from viscous environments.
Nat Commun, 13, 2022
7SQD
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BU of 7sqd by Molmil
Cryo-EM structure of the Achromobacter flagellar filament
Descriptor: Flagellin
Authors:Kreutzberger, M.A, Wang, F, Egelman, E.H.
Deposit date:2021-11-05
Release date:2022-03-16
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Flagellin outer domain dimerization modulates motility in pathogenic and soil bacteria from viscous environments.
Nat Commun, 13, 2022

 

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