5WDU

HIV-1 Env BG505 SOSIP.664 H72C-H564C trimer in complex with bNAbs PGT122 Fab, 35O22 Fab and NIH45-46 scFv

Summary for 5WDU

• Entry DOI: 10.2210/pdb5wdu/pdb
• Descriptor: Envelope glycoprotein gp160, alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (15 entities in total)
• Functional Keywords: hiv-1 env, broadly neutralizing antibodies, viral glycoprotein, immune system
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 21
• Total formula weight: 612662.84

Authors

Julien, J.-P.,Torrents de la Pena, A.,Sanders, R.W.,Wilson, I.A. (deposition date: 2017-07-06, release date: 2018-04-04, Last modification date: 2022-11-30)

• Primary citation: Torrents de la Pena, A.,Julien, J.P.,de Taeye, S.W.,Garces, F.,Guttman, M.,Ozorowski, G.,Pritchard, L.K.,Behrens, A.J.,Go, E.P.,Burger, J.A.,Schermer, E.E.,Sliepen, K.,Ketas, T.J.,Pugach, P.,Yasmeen, A.,Cottrell, C.A.,Torres, J.L.,Vavourakis, C.D.,van Gils, M.J.,LaBranche, C.,Montefiori, D.C.,Desaire, H.,Crispin, M.,Klasse, P.J.,Lee, K.K.,Moore, J.P.,Ward, A.B.,Wilson, I.A.,Sanders, R.W.; Improving the Immunogenicity of Native-like HIV-1 Envelope Trimers by Hyperstabilization.; Cell Rep, 20:1805-1817, 2017; PubMed: 28834745; DOI: 10.1016/j.celrep.2017.07.077

Experimental method

X-RAY DIFFRACTION (7 Å)