5WBS
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![BU of 5wbs by Molmil](/molmil-images/mine/5wbs) | Crystal structure of Frizzled-7 CRD with an inhibitor peptide Fz7-21 | Descriptor: | Frizzled-7,inhibitor peptide Fz7-21 | Authors: | Nile, A.H, Mukund, S, Hannoush, R.N, Wang, W. | Deposit date: | 2017-06-29 | Release date: | 2018-04-18 | Last modified: | 2018-05-30 | Method: | X-RAY DIFFRACTION (2.88 Å) | Cite: | A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells. Nat. Chem. Biol., 14, 2018
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5W96
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![BU of 5w96 by Molmil](/molmil-images/mine/5w96) | Solution structure of phage derived peptide inhibitor of frizzled 7 receptor | Descriptor: | Fz7 binding peptide | Authors: | Nile, A.H, de Sousa e Melo, F, Mukund, S, Piskol, R, Hansen, S, Zhou, L, Zhang, Y, Fu, Y, Gogol, E.B, Komuves, L.G, Modrusan, Z, Angers, S, Franke, Y, Koth, C, Fairbrother, W.J, Wang, W, de Sauvage, F.J, Hannoush, R.N. | Deposit date: | 2017-06-22 | Release date: | 2018-04-18 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells. Nat. Chem. Biol., 14, 2018
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5URV
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![BU of 5urv by Molmil](/molmil-images/mine/5urv) | Crystal structure of Frizzled 7 CRD in complex with C24 fatty acid | Descriptor: | (15E)-TETRACOS-15-ENOIC ACID, 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Mukund, S, Nile, A.H, Stanger, K, Hannoush, R.N, Wang, W. | Deposit date: | 2017-02-13 | Release date: | 2017-05-10 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Unsaturated fatty acyl recognition by Frizzled receptors mediates dimerization upon Wnt ligand binding. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5URZ
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![BU of 5urz by Molmil](/molmil-images/mine/5urz) | Crystal structure of Frizzled 5 CRD in complex with BOG | Descriptor: | Frizzled-5, alpha-L-fucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, octyl beta-D-glucopyranoside | Authors: | Mukund, S, Nile, A.H, Stanger, K, Hannoush, R.N, Wang, W. | Deposit date: | 2017-02-13 | Release date: | 2017-05-10 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.202 Å) | Cite: | Unsaturated fatty acyl recognition by Frizzled receptors mediates dimerization upon Wnt ligand binding. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5T44
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![BU of 5t44 by Molmil](/molmil-images/mine/5t44) | Crystal structure of Frizzled 7 CRD | Descriptor: | Frizzled-7 | Authors: | Mukund, S, Nile, A.H, Stanger, K, Hannous, R.H, Wang, W. | Deposit date: | 2016-08-29 | Release date: | 2017-04-05 | Last modified: | 2017-05-03 | Method: | X-RAY DIFFRACTION (1.9944 Å) | Cite: | Unsaturated fatty acyl recognition by Frizzled receptors mediates dimerization upon Wnt ligand binding. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5URY
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![BU of 5ury by Molmil](/molmil-images/mine/5ury) | Crystal structure of Frizzled 5 CRD in complex with PAM | Descriptor: | Frizzled-5, PALMITOLEIC ACID, alpha-L-fucopyranose-(1-3)-[alpha-L-fucopyranose-(1-4)][alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Mukund, S, Nile, A.H, Stanger, K, Hannoush, R.N, Wang, W. | Deposit date: | 2017-02-13 | Release date: | 2017-05-10 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.098 Å) | Cite: | Unsaturated fatty acyl recognition by Frizzled receptors mediates dimerization upon Wnt ligand binding. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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8GCR
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![BU of 8gcr by Molmil](/molmil-images/mine/8gcr) | HPV16 E6-E6AP-p53 complex | Descriptor: | Cellular tumor antigen p53, Maltose/maltodextrin-binding periplasmic protein,Protein E6, Ubiquitin-protein ligase E3A, ... | Authors: | Bratkowski, M.A, Wang, J.C.K, Hao, Q, Nile, A.H. | Deposit date: | 2023-03-02 | Release date: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.38 Å) | Cite: | Structure of the p53 degradation complex from HPV16. Nat Commun, 15, 2024
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7UFG
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![BU of 7ufg by Molmil](/molmil-images/mine/7ufg) | Cryo-EM structure of PAPP-A in complex with IGFBP5 | Descriptor: | Insulin-like growth factor-binding protein 5, Pappalysin-1, ZINC ION | Authors: | Judge, R.A, Jain, R, Hao, Q, Ouch, C, Sridar, J, Smith, C.L, Wang, J.C.K, Eaton, D. | Deposit date: | 2022-03-22 | Release date: | 2022-09-28 | Method: | ELECTRON MICROSCOPY (3.28 Å) | Cite: | Structure of the PAPP-ABP5 complex reveals mechanism of substrate recognition Nat Commun, 13, 2022
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8D8O
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![BU of 8d8o by Molmil](/molmil-images/mine/8d8o) | Cryo-EM structure of substrate unbound PAPP-A | Descriptor: | Pappalysin-1, ZINC ION | Authors: | Judge, R.A, Jain, R, Hao, Q, Ouch, C, Sridar, J, Smith, C.L, Wang, J.C.K, Eaton, D. | Deposit date: | 2022-06-08 | Release date: | 2022-09-28 | Method: | ELECTRON MICROSCOPY (3.35 Å) | Cite: | Structure of the PAPP-ABP5 complex reveals mechanism of substrate recognition Nat Commun, 13, 2022
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7NAM
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![BU of 7nam by Molmil](/molmil-images/mine/7nam) | LRP6_E1 in complex with Lr-EET-3.5 | Descriptor: | Low-density lipoprotein receptor-related protein 6, SODIUM ION, Trypsin inhibitor 2, ... | Authors: | Hansen, S, Hannoush, R.N. | Deposit date: | 2021-06-21 | Release date: | 2022-06-29 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Directed evolution identifies high-affinity cystine-knot peptide agonists and antagonists of Wnt/ beta-catenin signaling. Proc.Natl.Acad.Sci.USA, 119, 2022
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4M8Z
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![BU of 4m8z by Molmil](/molmil-images/mine/4m8z) | |
7ZGB
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![BU of 7zgb by Molmil](/molmil-images/mine/7zgb) | Structure of yeast Sec14p with NPPM112 | Descriptor: | 4-fluoranyl-~{N}-[(4-pyrrolidin-1-ylphenyl)methyl]benzamide, SEC14 cytosolic factor | Authors: | Hong, Z, Johnen, P, Schaaf, G, Bono, F. | Deposit date: | 2022-04-03 | Release date: | 2023-01-25 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Mechanisms by which small molecules of diverse chemotypes arrest Sec14 lipid transfer activity. J.Biol.Chem., 299, 2023
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7ZG9
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![BU of 7zg9 by Molmil](/molmil-images/mine/7zg9) | Structure of yeast Sec14p with himbacine | Descriptor: | Himbacine, SEC14 cytosolic factor | Authors: | Hong, Z, Johnen, P, Schaaf, G, Bono, F. | Deposit date: | 2022-04-03 | Release date: | 2023-01-25 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.764 Å) | Cite: | Mechanisms by which small molecules of diverse chemotypes arrest Sec14 lipid transfer activity. J.Biol.Chem., 299, 2023
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7ZGA
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![BU of 7zga by Molmil](/molmil-images/mine/7zga) | Structure of yeast Sec14p with ergoline | Descriptor: | SEC14 cytosolic factor, ~{O}9-methyl ~{O}4-[2,2,2-tris(chloranyl)ethyl] (5~{a}~{S},6~{a}~{S},9~{R},10~{a}~{S})-7-methyl-3-nitro-5,5~{a},6,6~{a},8,9,10,10~{a}-octahydroindolo[4,3-fg]quinoline-4,9-dicarboxylate | Authors: | Hong, Z, Johnen, P, Schaaf, G, Bono, F. | Deposit date: | 2022-04-03 | Release date: | 2023-01-25 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.302 Å) | Cite: | Mechanisms by which small molecules of diverse chemotypes arrest Sec14 lipid transfer activity. J.Biol.Chem., 299, 2023
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7ZGC
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![BU of 7zgc by Molmil](/molmil-images/mine/7zgc) | Structure of yeast Sec14p with NPPM481 | Descriptor: | (4-chloranyl-3-nitro-phenyl)-[4-(2-fluorophenyl)piperazin-1-yl]methanone, PHOSPHATE ION, SEC14 cytosolic factor | Authors: | Hong, Z, Johnen, P, Schaaf, G, Bono, F. | Deposit date: | 2022-04-03 | Release date: | 2023-01-25 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.236 Å) | Cite: | Mechanisms by which small molecules of diverse chemotypes arrest Sec14 lipid transfer activity. J.Biol.Chem., 299, 2023
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7ZGD
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![BU of 7zgd by Molmil](/molmil-images/mine/7zgd) | Structure of yeast Sec14p with NPPM244 | Descriptor: | (4-bromanyl-3-nitro-phenyl)-[4-(2-fluorophenyl)piperazin-1-yl]methanone, SEC14 cytosolic factor | Authors: | Hong, Z, Johnen, P, Schaaf, G, Bono, F. | Deposit date: | 2022-04-03 | Release date: | 2023-01-25 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | Mechanisms by which small molecules of diverse chemotypes arrest Sec14 lipid transfer activity. J.Biol.Chem., 299, 2023
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