5WBS

Crystal structure of Frizzled-7 CRD with an inhibitor peptide Fz7-21

Summary for 5WBS

Entry DOI	10.2210/pdb5wbs/pdb
Descriptor	Frizzled-7,inhibitor peptide Fz7-21 (2 entities in total)
Functional Keywords	frizzled, wnt signaling, inhibitor, dimerization, signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	8
Total formula weight	160842.31
Authors	Nile, A.H.,Mukund, S.,Hannoush, R.N.,Wang, W. (deposition date: 2017-06-29, release date: 2018-04-18, Last modification date: 2018-05-30)
Primary citation	Nile, A.H.,de Sousa E Melo, F.,Mukund, S.,Piskol, R.,Hansen, S.,Zhou, L.,Zhang, Y.,Fu, Y.,Gogol, E.B.,Komuves, L.G.,Modrusan, Z.,Angers, S.,Franke, Y.,Koth, C.,Fairbrother, W.J.,Wang, W.,de Sauvage, F.J.,Hannoush, R.N. A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells. Nat. Chem. Biol., 14:582-590, 2018 Cited by PubMed: 29632413 DOI: 10.1038/s41589-018-0035-2 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.88 Å)

Structure validation