1XAP
 
 | | Structure of the ligand binding domain of the Retinoic Acid Receptor beta | | Descriptor: | 4-[(1E)-2-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)PROP-1-ENYL]BENZOIC ACID, Retinoic acid receptor beta | | Authors: | Germain, P, Kammerer, S, Peluso-Iltis, C, Tortolani, D, Zusi, F.C, Starrett, J, Lapointe, P, Daris, J.P, Marinier, A, De Lera, A.R, Rochel, N, Gronemeyer, H. | | Deposit date: | 2004-08-26 | | Release date: | 2004-11-16 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Rational design of RAR-selective ligands revealed by RARbeta crystal structure
Embo Rep., 5, 2004
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6DEU
 | | Human caspase-6 A109T | | Descriptor: | Caspase-6 | | Authors: | Tubeleviciute-Aydin, A, Beautrait, A, Lynham, J, Sharma, G, Gorelik, A, Deny, L.J, Soya, N, Lukacs, G.L, Nagar, B, Marinier, A, LeBlanc, A.C. | | Deposit date: | 2018-05-13 | | Release date: | 2019-03-27 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.796 Å) | | Cite: | Identification of Allosteric Inhibitors against Active Caspase-6.
Sci Rep, 9, 2019
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6DEV
 | | Human caspase-6 E35K | | Descriptor: | Caspase-6 | | Authors: | Tubeleviciute-Aydin, A, Beautrait, A, Lynham, J, Sharma, G, Gorelik, A, Deny, L.J, Soya, N, Lukacs, G.L, Nagar, B, Marinier, A, LeBlanc, A.C. | | Deposit date: | 2018-05-13 | | Release date: | 2019-03-27 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.348 Å) | | Cite: | Identification of Allosteric Inhibitors against Active Caspase-6.
Sci Rep, 9, 2019
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7M2K
 | | CDC34A-Ubiquitin-2ab inhibitor complex | | Descriptor: | 4-[(3',5'-dichloro[1,1'-biphenyl]-4-yl)methyl]-N-ethyl-1-(methoxyacetyl)piperidine-4-carboxamide, Ubiquitin, Ubiquitin-conjugating enzyme E2 R1 | | Authors: | Ceccarelli, D.F, St-Cyr, D, Tyers, M, Sicheri, F. | | Deposit date: | 2021-03-16 | | Release date: | 2021-11-03 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.47 Å) | | Cite: | Identification and optimization of molecular glue compounds that inhibit a noncovalent E2 enzyme-ubiquitin complex.
Sci Adv, 7, 2021
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4WO5
 | | Crystal structure of a BRAF kinase domain monomer | | Descriptor: | N-{3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}propane-1-sulfonamide, Serine/threonine-protein kinase B-raf | | Authors: | Critton, D.A. | | Deposit date: | 2014-10-15 | | Release date: | 2014-12-03 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.83 Å) | | Cite: | Crystal structure of a BRAF kinase domain monomer explains basis for allosteric regulation.
Nat.Struct.Mol.Biol., 22, 2015
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4MDK
 | | Cdc34-ubiquitin-CC0651 complex | | Descriptor: | 4,5-dideoxy-5-(3',5'-dichlorobiphenyl-4-yl)-4-[(methoxyacetyl)amino]-L-arabinonic acid, Ubiquitin, Ubiquitin-conjugating enzyme E2 R1 | | Authors: | Ceccarelli, D.F, Orlicky, S, Tyers, M, Sicheri, F. | | Deposit date: | 2013-08-22 | | Release date: | 2013-12-11 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.6095 Å) | | Cite: | E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin.
Nat.Chem.Biol., 10, 2014
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6NY0
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6NXZ
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7R62
 | | Estrogen Receptor Alpha Ligand Binding Domain in Complex with a Desmethyl ICI164,384 Derivative | | Descriptor: | 11-[3,17beta-dihydroxyestra-1,3,5(10)-trien-7beta-yl]-N-methyl-N-propylundecanamide, Estrogen receptor | | Authors: | Diennet, M, El Ezzy, M, Thiombane, K, Cotnoir-White, D, Poupart, J, Gao, Z, Mendoza Sanchez, R, Marinier, A, Gleason, J, Greene, G.L, Mader, S.C, Fanning, S.W. | | Deposit date: | 2021-06-22 | | Release date: | 2022-07-06 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Estrogen Receptor Alpha Ligand Binding Domain in Complex with a Desmethyl ICI164,384 Derivative
To Be Published
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7N9O
 | | Estrogen Receptor Alpha Ligand Binding Domain in Complex with Aliphatic SERD S-C10(15) | | Descriptor: | 10-{[3,17beta-dihydroxyestra-1,3,5(10)-trien-7beta-yl]sulfanyl}-N-methyl-N-propyldecanamide, Estrogen receptor | | Authors: | Diennet, M, El Ezzy, M, Thiombane, K, Cotnoir-White, D, Poupart, J, Gao, Z, Mendoza, S.R, Marinier, A, Gleason, J, Mader, S.C, Fanning, S.W. | | Deposit date: | 2021-06-18 | | Release date: | 2022-07-06 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Estrogen Receptor Alpha Ligand Binding Domain in Complex with Aliphatic SERD S-C10(15)
To Be Published
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9CUM
 | | Q67H mutant of R67 DHFR complexed with Congo Red | | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, Dihydrofolate reductase type 2, ... | | Authors: | Narayana, N, Narendra, A.N. | | Deposit date: | 2024-07-26 | | Release date: | 2025-02-19 | | Last modified: | 2025-02-26 | | Method: | X-RAY DIFFRACTION (1.15 Å) | | Cite: | Crystal structure of the plasmid-encoded R67 dihydrofolate reductase complexed with Congo red an amyloid binding dye.
Sci Rep, 15, 2025
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8VYQ
 | | Cryo-EM Structure of the BRAF V600K monomer | | Descriptor: | 14-3-3 protein zeta/delta, Serine/threonine-protein kinase B-raf | | Authors: | Lavoie, H, Lajoie, D, Jin, T, Decossas, M, Maisonneuve, P, Therrien, M. | | Deposit date: | 2024-02-09 | | Release date: | 2025-05-28 | | Last modified: | 2025-06-11 | | Method: | ELECTRON MICROSCOPY (4.43 Å) | | Cite: | BRAF oncogenic mutants evade autoinhibition through a common mechanism.
Science, 388, 2025
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8VYR
 | | Cryo-EM Structure of the BRAF V600E monomer bound to GDC0879 | | Descriptor: | 14-3-3 protein zeta/delta, Serine/threonine-protein kinase B-raf | | Authors: | Lavoie, H, Lajoie, D, Jin, T, Decossas, M, Maisonneuve, P, Therrien, M. | | Deposit date: | 2024-02-09 | | Release date: | 2025-05-28 | | Last modified: | 2025-06-11 | | Method: | ELECTRON MICROSCOPY (4.32 Å) | | Cite: | BRAF oncogenic mutants evade autoinhibition through a common mechanism.
Science, 388, 2025
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8VYS
 | | Cryo-EM Structure of the BRAF V600E monomer bound to PLX8394 | | Descriptor: | (3S)-N-{3-[5-(2-cyclopropylpyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl}-3-fluoropyrrolidine-1-sulfonamide, 14-3-3 protein zeta/delta, Serine/threonine-protein kinase B-raf | | Authors: | Lavoie, H, Lajoie, D, Jin, T, Decossas, M, Maisonneuve, P, Therrien, M. | | Deposit date: | 2024-02-09 | | Release date: | 2025-05-28 | | Last modified: | 2025-06-11 | | Method: | ELECTRON MICROSCOPY (3.06 Å) | | Cite: | BRAF oncogenic mutants evade autoinhibition through a common mechanism.
Science, 388, 2025
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8VYU
 | | Cryo-EM Structure of the BRAF WT monomer bound to PLX8394 | | Descriptor: | (3S)-N-{3-[5-(2-cyclopropylpyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl}-3-fluoropyrrolidine-1-sulfonamide, 14-3-3 protein zeta/delta, Serine/threonine-protein kinase B-raf | | Authors: | Lavoie, H, Lajoie, D, Jin, T, Decossas, M, Maisonneuve, P, Therrien, M. | | Deposit date: | 2024-02-09 | | Release date: | 2025-05-28 | | Last modified: | 2025-06-11 | | Method: | ELECTRON MICROSCOPY (4.07 Å) | | Cite: | BRAF oncogenic mutants evade autoinhibition through a common mechanism.
Science, 388, 2025
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8VYV
 | | Cryo-EM Structure of the BRAF K601E monomer | | Descriptor: | 14-3-3 protein zeta/delta, Serine/threonine-protein kinase B-raf | | Authors: | Lavoie, H, Lajoie, D, Jin, T, Decossas, M, Maisonneuve, P, Therrien, M. | | Deposit date: | 2024-02-09 | | Release date: | 2025-05-28 | | Last modified: | 2025-06-11 | | Method: | ELECTRON MICROSCOPY (5.86 Å) | | Cite: | BRAF oncogenic mutants evade autoinhibition through a common mechanism.
Science, 388, 2025
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8VYP
 | | Cryo-EM Structure of the BRAF V600E monomer | | Descriptor: | 14-3-3 protein zeta/delta, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase B-raf | | Authors: | Lavoie, H, Lajoie, D, Jin, T, Decossas, M, Maisonneuve, P, Therrien, M. | | Deposit date: | 2024-02-09 | | Release date: | 2025-05-28 | | Last modified: | 2025-06-11 | | Method: | ELECTRON MICROSCOPY (3.29 Å) | | Cite: | BRAF oncogenic mutants evade autoinhibition through a common mechanism.
Science, 388, 2025
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8VYW
 | | Cryo-EM Structure of the BRAF D594G monomer | | Descriptor: | 14-3-3 protein zeta/delta, Serine/threonine-protein kinase B-raf | | Authors: | Lavoie, H, Lajoie, D, Jin, T, Decossas, M, Maisonneuve, P, Therrien, M. | | Deposit date: | 2024-02-09 | | Release date: | 2025-05-28 | | Last modified: | 2025-06-11 | | Method: | ELECTRON MICROSCOPY (4.76 Å) | | Cite: | BRAF oncogenic mutants evade autoinhibition through a common mechanism.
Science, 388, 2025
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8VYO
 | | Cryo-EM Structure of the BRAF WT monomer | | Descriptor: | 14-3-3 protein zeta/delta, Serine/threonine-protein kinase B-raf, ZINC ION | | Authors: | Lavoie, H, Lajoie, D, Jin, T, Decossas, M, Maisonneuve, P, Therrien, M. | | Deposit date: | 2024-02-09 | | Release date: | 2025-05-28 | | Last modified: | 2025-06-11 | | Method: | ELECTRON MICROSCOPY (3.74 Å) | | Cite: | BRAF oncogenic mutants evade autoinhibition through a common mechanism.
Science, 388, 2025
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6H5N
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7ZXF
 | | Pfs48/45 bound to monoclonal antibodies 10D8 and 85RF45.1 | | Descriptor: | 10D8 heavy chain, 10D8 light chain, 85RF45.1 heavy chain, ... | | Authors: | Ko, K.T, Lennartz, F.L, Higgins, M.K. | | Deposit date: | 2022-05-20 | | Release date: | 2022-06-22 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (3.72 Å) | | Cite: | Structure of the malaria vaccine candidate Pfs48/45 and its recognition by transmission blocking antibodies.
Nat Commun, 13, 2022
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7ZWF
 | | Pfs48/45 bound to scFv fragment of monoclonal antibody 32F3 | | Descriptor: | 32F3scFv, Gametocyte surface protein P45/48, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | | Authors: | Ko, K.T, Lennartz, F.L, Higgins, M.K. | | Deposit date: | 2022-05-19 | | Release date: | 2022-06-22 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.132 Å) | | Cite: | Structure of the malaria vaccine candidate Pfs48/45 and its recognition by transmission blocking antibodies.
Nat Commun, 13, 2022
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7ZWI
 | | Pfs48/45 C-terminal domain bound to fab fragment of monoclonal antibody 32F3 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 32F3 heavy chain, 32F3 light chain, ... | | Authors: | Ko, K.T, Lennartz, F.L, Higgins, M.K. | | Deposit date: | 2022-05-19 | | Release date: | 2022-06-22 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structure of the malaria vaccine candidate Pfs48/45 and its recognition by transmission blocking antibodies.
Nat Commun, 13, 2022
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7ZXG
 | | Pfs48/45 bound to Fab fragment of monoclonal antibody 10D8 | | Descriptor: | 10D8 heavy chain, 10D8 light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Ko, K.T, Lennartz, F.L, Higgins, M.K. | | Deposit date: | 2022-05-20 | | Release date: | 2022-06-22 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (4.2 Å) | | Cite: | Structure of the malaria vaccine candidate Pfs48/45 and its recognition by transmission blocking antibodies.
Nat Commun, 13, 2022
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7ZWM
 | | Pfs48/45 central and C-terminal domains bound to Fab fragments of monoclonal antibody 10D8 and 32F3 | | Descriptor: | 10D8 heavy chain, 10D8 light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Ko, K.T, Lennartz, F.L, Higgins, M.K. | | Deposit date: | 2022-05-19 | | Release date: | 2022-06-22 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (3.69 Å) | | Cite: | Structure of the malaria vaccine candidate Pfs48/45 and its recognition by transmission blocking antibodies.
Nat Commun, 13, 2022
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