4MDK

Cdc34-ubiquitin-CC0651 complex

Summary for 4MDK

DescriptorUbiquitin-conjugating enzyme E2 R1, Ubiquitin, 4,5-dideoxy-5-(3',5'-dichlorobiphenyl-4-yl)-4-[(methoxyacetyl)amino]-L-arabinonic acid, ... (4 entities in total)
Functional Keywordsubiquitin conjugating enzyme domain, e2 ligase inhibitor, ligase-ligase inhibitor complex, ligase/ligase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm P49427
Ubiquitin: Cytoplasm (By similarity) P0CG48
Total number of polymer chains8
Total molecular weight119342.64
Authors
Ceccarelli, D.F.,Orlicky, S.,Tyers, M.,Sicheri, F. (deposition date: 2013-08-22, release date: 2013-12-11, Last modification date: 2014-02-05)
Primary citation
Huang, H.,Ceccarelli, D.F.,Orlicky, S.,St-Cyr, D.J.,Ziemba, A.,Garg, P.,Plamondon, S.,Auer, M.,Sidhu, S.,Marinier, A.,Kleiger, G.,Tyers, M.,Sicheri, F.
E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin.
Nat.Chem.Biol., 10:156-163, 2014
PubMed: 24316736 (PDB entries with the same primary citation)
DOI: 10.1038/nchembio.1412
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.6095 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.25990.1%8.4%0.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report