4WO5
Crystal structure of a BRAF kinase domain monomer
Summary for 4WO5
Entry DOI | 10.2210/pdb4wo5/pdb |
Related | 3C4C |
Descriptor | Serine/threonine-protein kinase B-raf, N-{3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}propane-1-sulfonamide (3 entities in total) |
Functional Keywords | kinase, monomer, inhibitor, complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : P15056 |
Total number of polymer chains | 2 |
Total formula weight | 69061.48 |
Authors | Critton, D.A. (deposition date: 2014-10-15, release date: 2014-12-03, Last modification date: 2023-09-27) |
Primary citation | Thevakumaran, N.,Lavoie, H.,Critton, D.A.,Tebben, A.,Marinier, A.,Sicheri, F.,Therrien, M. Crystal structure of a BRAF kinase domain monomer explains basis for allosteric regulation. Nat.Struct.Mol.Biol., 22:37-43, 2015 Cited by PubMed: 25437913DOI: 10.1038/nsmb.2924 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.83 Å) |
Structure validation
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