Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

3C4C

B-Raf Kinase in Complex with PLX4720

Summary for 3C4C
Entry DOI10.2210/pdb3c4c/pdb
Related3C4D
DescriptorB-Raf proto-oncogene serine/threonine-protein kinase, N-{3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}propane-1-sulfonamide (3 entities in total)
Functional Keywordsb-raf, braf, raf, proto-oncogene, serine/threonine kinase, atp-binding, cardiomyopathy, cytoplasm, disease mutation, metal-binding, nucleotide-binding, phorbol-ester binding, phosphoprotein, polymorphism, serine/threonine-protein kinase, transferase, zinc, zinc-finger
Biological sourceHomo sapiens (human)
Cellular locationNucleus (By similarity): P15056
Total number of polymer chains2
Total formula weight64578.71
Authors
Zhang, K.Y.J.,Wang, W. (deposition date: 2008-01-29, release date: 2008-02-26, Last modification date: 2024-02-21)
Primary citationTsai, J.,Lee, J.T.,Wang, W.,Zhang, J.,Cho, H.,Mamo, S.,Bremer, R.,Gillette, S.,Kong, J.,Haass, N.K.,Sproesser, K.,Li, L.,Smalley, K.S.,Fong, D.,Zhu, Y.L.,Marimuthu, A.,Nguyen, H.,Lam, B.,Liu, J.,Cheung, I.,Rice, J.,Suzuki, Y.,Luu, C.,Settachatgul, C.,Shellooe, R.,Cantwell, J.,Kim, S.H.,Schlessinger, J.,Zhang, K.Y.,West, B.L.,Powell, B.,Habets, G.,Zhang, C.,Ibrahim, P.N.,Hirth, P.,Artis, D.R.,Herlyn, M.,Bollag, G.
Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity
Proc.Natl.Acad.Sci.Usa, 105:3041-3046, 2008
Cited by
PubMed: 18287029
DOI: 10.1073/pnas.0711741105
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.57 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon