3C4C
B-Raf Kinase in Complex with PLX4720
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | B-Raf proto-oncogene serine/threonine-protein kinase | polymer | 280 | 31875.5 | 2 | UniProt (P15056) Pfam (PF07714) In PDB | Homo sapiens (human) | p94, v-Raf murine sarcoma viral oncogene homolog B1 |
2 | A, B | N-{3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}propane-1-sulfonamide | non-polymer | 413.8 | 2 | Chemie (324) | |||
3 | water | water | 18.0 | 153 | Chemie (HOH) |
Sequence modifications
A, B: 444 - 721 (UniProt: P15056)
PDB | External Database | Details |
---|---|---|
Ala 543 | Ile 543 | engineered mutation |
Ser 544 | Ile 544 | engineered mutation |
Lys 551 | Ile 551 | engineered mutation |
Arg 562 | Gln 562 | engineered mutation |
Asn 588 | Leu 588 | engineered mutation |
Ser 630 | Lys 630 | engineered mutation |
Glu 667 | Phe 667 | engineered mutation |
Ser 673 | Tyr 673 | engineered mutation |
Arg 688 | Ala 688 | engineered mutation |
Ser 706 | Leu 706 | engineered mutation |
Arg 709 | Gln 709 | engineered mutation |
Glu 713 | Ser 713 | engineered mutation |
Glu 716 | Leu 716 | engineered mutation |
Glu 720 | Ser 720 | engineered mutation |
Ser 722 | - | expression tag |
Gly 723 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 63751.1 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 827.7 | |
All* | Total formula weight | 64578.7 |