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4WO5

Crystal structure of a BRAF kinase domain monomer

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BSerine/threonine-protein kinase B-rafpolymer30034116.92UniProt (P15056)
Pfam (PF07714)
In PDB
Homo sapiens (Human)Proto-oncogene B-Raf,p94,v-Raf murine sarcoma viral oncogene homolog B1
2A, BN-{3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}propane-1-sulfonamidenon-polymer413.82Chemie (324)
3waterwater18.077Chemie (HOH)
Sequence modifications
A, B: 444 - 723 (UniProt: P15056)
PDBExternal DatabaseDetails
Met 424-initiating methionine
Gly 425-expression tag
Ser 426-expression tag
Ser 427-expression tag
His 428-expression tag
His 429-expression tag
His 430-expression tag
His 431-expression tag
His 432-expression tag
His 433-expression tag
Ser 434-expression tag
Ser 435-expression tag
Gly 436-expression tag
Glu 437-expression tag
Thr 438-expression tag
Val 439-expression tag
Arg 440-expression tag
Phe 441-expression tag
Gln 442-expression tag
Gly 443-expression tag
Ala 543Ile 543engineered mutation
Ser 544Ile 544engineered mutation
Lys 551Ile 551engineered mutation
Arg 562Gln 562engineered mutation
Asn 588Leu 588engineered mutation
Ser 630Lys 630engineered mutation
Glu 667Phe 667engineered mutation
Ser 673Tyr 673engineered mutation
Arg 688Ala 688engineered mutation
Ser 706Leu 706engineered mutation
Arg 709Gln 709engineered mutation
Glu 713Ser 713engineered mutation
Glu 716Leu 716engineered mutation
Glu 720Ser 720engineered mutation
Ser 722Pro 722engineered mutation
Gly 723Lys 723engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight68233.8
Non-Polymers*Number of molecules2
Total formula weight827.7
All*Total formula weight69061.5
*Water molecules are not included.

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PDB entries from 2024-06-12

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