8VYW

Cryo-EM Structure of the BRAF D594G monomer

Summary for 8VYW

• Entry DOI: 10.2210/pdb8vyw/pdb
• EMDB information: 43680
• Descriptor: 14-3-3 protein zeta/delta, Serine/threonine-protein kinase B-raf (2 entities in total)
• Functional Keywords: braf kinase oncogenic mutant monomer, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 97746.20

Authors

Lavoie, H.,Lajoie, D.,Jin, T.,Decossas, M.,Maisonneuve, P.,Therrien, M. (deposition date: 2024-02-09, release date: 2025-05-28)

• Primary citation: Lavoie, H.,Jin, T.,Lajoie, D.,Decossas, M.,Gendron, P.,Wang, B.,Filandr, F.,Sahmi, M.,Hwa Jo, C.,Weber, S.,Arseneault, G.,Tripathy, S.,Beaulieu, P.,Schuetz, D.A.,Schriemer, D.C.,Marinier, A.,Rice, W.J.,Maisonneuve, P.,Therrien, M.; BRAF oncogenic mutants evade autoinhibition through a common mechanism; Science, 2025; DOI: 10.1126/science.adp2742

Experimental method

ELECTRON MICROSCOPY (4.76 Å)