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1SDD
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BU of 1sdd by Molmil
Crystal Structure of Bovine Factor Vai
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, COPPER (II) ION, ...
著者Adams, T.E, Hockin, M.F, Mann, K.G, Everse, S.J.
登録日2004-02-13
公開日2004-06-29
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献The crystal structure of activated protein C-inactivated bovine factor Va: Implications for cofactor function.
Proc.Natl.Acad.Sci.USA, 101, 2004
1HAI
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BU of 1hai by Molmil
THE ISOMORPHOUS STRUCTURES OF PRETHROMBIN2, HIRUGEN-AND PPACK-THROMBIN: CHANGES ACCOMPANYING ACTIVATION AND EXOSITE BINDING TO THROMBIN
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), ...
著者Tulinsky, A, Vijayalakshmi, J.
登録日1994-06-27
公開日1994-12-20
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献The isomorphous structures of prethrombin2, hirugen-, and PPACK-thrombin: changes accompanying activation and exosite binding to thrombin.
Protein Sci., 3, 1994
1HAH
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BU of 1hah by Molmil
THE ISOMORPHOUS STRUCTURES OF PRETHROMBIN2, HIRUGEN-AND PPACK-THROMBIN: CHANGES ACCOMPANYING ACTIVATION AND EXOSITE BINDING TO THROMBIN
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), ...
著者Tulinsky, A, Vijayalakshmi, J.
登録日1994-06-27
公開日1994-12-20
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The isomorphous structures of prethrombin2, hirugen-, and PPACK-thrombin: changes accompanying activation and exosite binding to thrombin.
Protein Sci., 3, 1994
1HAG
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BU of 1hag by Molmil
THE ISOMORPHOUS STRUCTURES OF PRETHROMBIN2, HIRUGEN-AND PPACK-THROMBIN: CHANGES ACCOMPANYING ACTIVATION AND EXOSITE BINDING TO THROMBIN
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, HIRUGEN, PRETHROMBIN 2
著者Tulinsky, A, Vijayalakshmi, J.
登録日1994-06-27
公開日1994-12-20
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The isomorphous structures of prethrombin2, hirugen-, and PPACK-thrombin: changes accompanying activation and exosite binding to thrombin.
Protein Sci., 3, 1994
1PPB
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BU of 1ppb by Molmil
THE REFINED 1.9 ANGSTROMS CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN: INTERACTION WITH D-PHE-PRO-ARG CHLOROMETHYLKETONE AND SIGNIFICANCE OF THE TYR-PRO-PRO-TRP INSERTION SEGMENT
分子名称: ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide
著者Bode, W.
登録日1991-10-24
公開日1994-01-31
最終更新日2013-02-27
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献The refined 1.9 A crystal structure of human alpha-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment.
EMBO J., 8, 1989
1TBZ
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BU of 1tbz by Molmil
HUMAN THROMBIN WITH ACTIVE SITE N-METHYL-D PHENYLALANYL-N-[5-(AMINOIMINOMETHYL)AMINO]-1-{{BENZOTHIAZOLYL)CARBONYL] BUTYL]-L-PROLINAMIDE TRIFLUROACETATE AND EXOSITE-HIRUGEN
分子名称: ALPHA-THROMBIN, D-phenylalanyl-N-{(1S)-1-[(S)-1,3-benzothiazol-2-yl(hydroxy)methyl]-4-carbamimidamidobutyl}-L-prolinamide, HIRUGEN, ...
著者Matthews, J.H, Krishnan, R, Costanzo, M.J, Maryanoff, B.E, Tulinsky, A.
登録日1998-02-05
公開日1998-05-27
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structures of thrombin with thiazole-containing inhibitors: probes of the S1' binding site.
Biophys.J., 71, 1996
3SQH
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BU of 3sqh by Molmil
Crystal structure of prethrombin-2 mutant S195A in the the open form
分子名称: Thrombin light chain, heavy chain
著者Pozzi, N, Chen, Z, Di Cera, E.
登録日2011-07-05
公開日2011-11-30
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structures of prethrombin-2 reveal alternative conformations under identical solution conditions and the mechanism of zymogen activation.
Biochemistry, 50, 2011
3SQE
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BU of 3sqe by Molmil
Crystal structure of prethrombin-2 mutant S195A in the alternative form
分子名称: GLYCEROL, Thrombin light chain, heavy chain
著者Pozzi, N, Chen, Z, Di Cera, E.
登録日2011-07-05
公開日2011-11-30
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structures of prethrombin-2 reveal alternative conformations under identical solution conditions and the mechanism of zymogen activation.
Biochemistry, 50, 2011
1A4W
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BU of 1a4w by Molmil
CRYSTAL STRUCTURES OF THROMBIN WITH THIAZOLE-CONTAINING INHIBITORS: PROBES OF THE S1' BINDING SITE
分子名称: ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), HIRUGEN, ...
著者Matthews, J.H, Krishnan, R, Costanzo, M.J, Maryanoff, B.E, Tulinsky, A.
登録日1998-02-06
公開日1998-04-29
最終更新日2023-08-02
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structures of thrombin with thiazole-containing inhibitors: probes of the S1' binding site.
Biophys.J., 71, 1996
3HAT
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BU of 3hat by Molmil
ACTIVE SITE MIMETIC INHIBITION OF THROMBIN
分子名称: FPAM (FIBRINOPEPTIDE A MIMIC), Hirudin variant-2, Thrombin heavy chain, ...
著者Tulinsky, A, Mathews, I.I.
登録日1994-10-16
公開日1995-02-27
最終更新日2024-04-24
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Active-site mimetic inhibition of thrombin.
Acta Crystallogr.,Sect.D, 51, 1995
1HXF
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BU of 1hxf by Molmil
HUMAN THROMBIN COMPLEX WITH HIRUDIN VARIANT
分子名称: HIRUDIN VARIANT, THROMBIN
著者Tulinsky, A, Zhang, E.
登録日1996-09-09
公開日1997-01-27
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The molecular environment of the Na+ binding site of thrombin.
Biophys.Chem., 63, 1997
1MKX
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BU of 1mkx by Molmil
THE CO-CRYSTAL STRUCTURE OF UNLIGANDED BOVINE ALPHA-THROMBIN AND PRETHROMBIN-2: MOVEMENT OF THE YPPW SEGMENT AND ACTIVE SITE RESIDUES UPON LIGAND BINDING
分子名称: ALPHA-THROMBIN, PRETHROMBIN-2
著者Malkowski, M.G, Edwards, B.F.P.
登録日1997-03-13
公開日1997-07-07
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The co-crystal structure of unliganded bovine alpha-thrombin and prethrombin-2: movement of the Tyr-Pro-Pro-Trp segment and active site residues upon ligand binding.
Protein Sci., 6, 1997
1MKW
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BU of 1mkw by Molmil
THE CO-CRYSTAL STRUCTURE OF UNLIGANDED BOVINE ALPHA-THROMBIN AND PRETHROMBIN-2: MOVEMENT OF THE YPPW SEGMENT AND ACTIVE SITE RESIDUES UPON LIGAND BINDING
分子名称: ALPHA-THROMBIN, PRETHROMBIN-2
著者Malkowski, M.G, Edwards, B.F.P.
登録日1997-03-13
公開日1997-07-07
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The co-crystal structure of unliganded bovine alpha-thrombin and prethrombin-2: movement of the Tyr-Pro-Pro-Trp segment and active site residues upon ligand binding.
Protein Sci., 6, 1997
1FPC
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BU of 1fpc by Molmil
ACTIVE SITE MIMETIC INHIBITION OF THROMBIN
分子名称: Hirudin, amino{[(4S)-4-({[5-(dimethylamino)naphthalen-1-yl]sulfonyl}amino)-5-(4-ethylpiperidin-1-yl)-5-oxopentyl]amino}methaniminium, thrombin
著者Tulinsky, A, Mathews, I.I.
登録日1994-10-16
公開日1995-02-27
最終更新日2012-12-12
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Active-site mimetic inhibition of thrombin.
Acta Crystallogr.,Sect.D, 51, 1995

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