1TBZ

HUMAN THROMBIN WITH ACTIVE SITE N-METHYL-D PHENYLALANYL-N-[5-(AMINOIMINOMETHYL)AMINO]-1-{{BENZOTHIAZOLYL)CARBONYL] BUTYL]-L-PROLINAMIDE TRIFLUROACETATE AND EXOSITE-HIRUGEN

Summary for 1TBZ
Related PRD IDPRD_000621
DescriptorALPHA-THROMBIN, HIRUGEN, D-phenylalanyl-N-{(1S)-1-[(S)-1,3-benzothiazol-2-yl(hydroxy)methyl]-4-carbamimidamidobutyl}-L-prolinamide, ... (6 entities in total)
Functional Keywordscomplex (serine protease-inhibitor), hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
More
Cellular locationSecreted, extracellular space: P00734 P09945
Secreted: P00734
Total number of polymer chains3
Total formula weight35994.96
Authors
Matthews, J.H.,Krishnan, R.,Costanzo, M.J.,Maryanoff, B.E.,Tulinsky, A. (deposition date: 1998-02-05, release date: 1998-05-27, Last modification date: 2012-12-12)
Primary citationCostanzo, M.J.,Krishnan, R.,Maryanoff, B.E.,Matthews, J.H.,Tulinsky, A.
Crystal structures of thrombin with thiazole-containing inhibitors: probes of the S1' binding site.
Biophys.J., 71:2830-2839, 1996
PubMed: 8913620
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.3 Å)
Structure validation
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PDB entries from 2021-06-23