1FPC
ACTIVE SITE MIMETIC INHIBITION OF THROMBIN
Summary for 1FPC
| Entry DOI | 10.2210/pdb1fpc/pdb |
| Related PRD ID | PRD_000376 |
| Descriptor | thrombin, Hirudin, amino{[(4S)-4-({[5-(dimethylamino)naphthalen-1-yl]sulfonyl}amino)-5-(4-ethylpiperidin-1-yl)-5-oxopentyl]amino}methaniminium, ... (5 entities in total) |
| Functional Keywords | serine protease-inhibitor complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Hirudo medicinalis (Medicinal leech) More |
| Cellular location | Secreted, extracellular space: P00734 P00734 Secreted: P28504 |
| Total number of polymer chains | 3 |
| Total formula weight | 35914.99 |
| Authors | Tulinsky, A.,Mathews, I.I. (deposition date: 1994-10-16, release date: 1995-02-27, Last modification date: 2024-06-05) |
| Primary citation | Mathews, I.I.,Tulinsky, A. Active-site mimetic inhibition of thrombin. Acta Crystallogr.,Sect.D, 51:550-559, 1995 Cited by PubMed: 15299843DOI: 10.1107/S0907444994013132 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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