1FPC
ACTIVE SITE MIMETIC INHIBITION OF THROMBIN
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (L) | thrombin | polymer | 36 | 4096.5 | 1 | UniProt (P00734) Pfam (PF09396) | Homo sapiens (human) | Coagulation factor II |
| 2 | B (H) | thrombin | polymer | 259 | 29780.2 | 1 | UniProt (P00734) Pfam (PF00089) | Homo sapiens (human) | Coagulation factor II |
| 3 | C (I) | Hirudin | polymer | 12 | 1534.6 | 1 | UniProt (P28504) | Hirudo medicinalis (Medicinal leech) | |
| 4 | D (H) | amino{[(4S)-4-({[5-(dimethylamino)naphthalen-1-yl]sulfonyl}amino)-5-(4-ethylpiperidin-1-yl)-5-oxopentyl]amino}methaniminium | non-polymer | 503.7 | 1 | BIRD (PRD_000376) Chemie (0ZI) | |||
| 5 | E, F, G (L, H, I) | water | water | 18.0 | 201 | Chemie (HOH) |
Sequence modifications
I: 53 - 64 (UniProt: P28504)
| PDB | External Database | Details |
|---|---|---|
| Asn 53 | Asp 53 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 35411.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 503.7 | |
| All* | Total formula weight | 35915.0 |
