6CWZ
 
 | | Crystal structure of apo SUMO E1 | | 分子名称: | SUMO-activating enzyme subunit 1, SUMO-activating enzyme subunit 2, ZINC ION | | 著者 | Lv, Z, Yuan, L, Atkison, J.H, Williams, K.M, Olsen, S.K. | | 登録日 | 2018-04-01 | | 公開日 | 2019-01-16 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme.
Nat Commun, 9, 2018
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6DC6
 | | Crystal structure of human ubiquitin activating enzyme E1 (Uba1) in complex with ubiquitin | | 分子名称: | MAGNESIUM ION, PYROPHOSPHATE 2-, Ubiquitin, ... | | 著者 | Lv, Z, Yuan, L, Williams, K.M, Atkison, J.H, Olsen, S.K. | | 登録日 | 2018-05-04 | | 公開日 | 2018-10-10 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3.14 Å) | | 主引用文献 | Crystal structure of a human ubiquitin E1-ubiquitin complex reveals conserved functional elements essential for activity.
J. Biol. Chem., 293, 2018
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4HA9
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4HA7
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5UM6
 | | Crystal Structure of S. pombe Uba1 in a closed conformation | | 分子名称: | 2-(decylamino)ethane-1-thiol, N-(2-{[(4-chlorophenyl)methyl]disulfanyl}ethyl)decan-1-amine, SULFATE ION, ... | | 著者 | Lv, Z, Yuan, L, Aldana-Masangkay, G, Atkison, J.H, Chen, Y, Olsen, S.K. | | 登録日 | 2017-01-26 | | 公開日 | 2017-06-14 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.794 Å) | | 主引用文献 | Domain alternation and active site remodeling are conserved structural features of ubiquitin E1.
J. Biol. Chem., 292, 2017
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6CWY
 | | Crystal structure of SUMO E1 in complex with an allosteric inhibitor | | 分子名称: | GLYCEROL, MAGNESIUM ION, SULFATE ION, ... | | 著者 | Lv, Z, Yuan, L, Atkison, J.H, Williams, K.M, Olsen, S.K. | | 登録日 | 2018-04-01 | | 公開日 | 2019-01-16 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.462 Å) | | 主引用文献 | Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme.
Nat Commun, 9, 2018
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5KNL
 | | Crystal structure of S. pombe ubiquitin E1 (Uba1) in complex with Ubc15 and ubiquitin | | 分子名称: | SULFATE ION, Ubiquitin, Ubiquitin-activating enzyme E1 1, ... | | 著者 | Olsen, S.K, Lv, Z, Yuan, L, Williams, K. | | 登録日 | 2016-06-28 | | 公開日 | 2017-02-15 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | S. pombe Uba1-Ubc15 Structure Reveals a Novel Regulatory Mechanism of Ubiquitin E2 Activity.
Mol. Cell, 65, 2017
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6WUU
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6WX4
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5JHH
 | | Crystal structure of the ternary complex between the human RhoA, its inhibitor and the DH/PH domain of human ARHGEF11 | | 分子名称: | 3-{3-[ethyl(quinolin-2-yl)amino]phenyl}propanoic acid, GLYCEROL, Rho guanine nucleotide exchange factor 11, ... | | 著者 | Lv, Z, Wang, R, Ma, L, Miao, Q, Wu, J, Yan, Z, Li, J, Miao, L, Wang, F. | | 登録日 | 2016-04-21 | | 公開日 | 2017-04-26 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystallization and preliminary X-ray crystallographic analysis of a small GTPase RhoA bound with its inhibitor and PDZRhoGEF
To Be Published
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4J0U
 | | Crystal structure of IFIT5/ISG58 | | 分子名称: | Interferon-induced protein with tetratricopeptide repeats 5 | | 著者 | Liu, Y, Liang, H, Feng, F, Yuan, L, Wang, Y.E, Crowley, C, Lv, Z, Li, J, Zeng, S, Cheng, G. | | 登録日 | 2013-01-31 | | 公開日 | 2013-02-13 | | 実験手法 | X-RAY DIFFRACTION (1.969 Å) | | 主引用文献 | Crystal Structure of IFIT5
To be Published
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3UA3
 | | Crystal Structure of Protein Arginine Methyltransferase PRMT5 in complex with SAH | | 分子名称: | Protein arginine N-methyltransferase 5, S-ADENOSYL-L-HOMOCYSTEINE | | 著者 | Sun, L, Wang, M, Lv, Z, Yang, N, Liu, Y, Bao, S, Gong, W, Xu, R.M. | | 登録日 | 2011-10-20 | | 公開日 | 2011-12-14 | | 最終更新日 | 2011-12-28 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structural insights into protein arginine symmetric dimethylation by PRMT5
Proc.Natl.Acad.Sci.USA, 108, 2011
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3UA4
 | | Crystal Structure of Protein Arginine Methyltransferase PRMT5 | | 分子名称: | GLYCEROL, Protein arginine N-methyltransferase 5 | | 著者 | Sun, L, Wang, M, Lv, Z, Yang, N, Liu, Y, Bao, S, Gong, W, Xu, R.M. | | 登録日 | 2011-10-21 | | 公開日 | 2011-12-14 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (3.005 Å) | | 主引用文献 | Structural insights into protein arginine symmetric dimethylation by PRMT5
Proc.Natl.Acad.Sci.USA, 108, 2011
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8WFQ
 | | The Crystal Structure of RALDH1 from Biortus. | | 分子名称: | 1,2-ETHANEDIOL, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Aldehyde dehydrogenase 1A1 | | 著者 | Wang, F, Cheng, W, Lv, Z, Qi, J, Shen, Z. | | 登録日 | 2023-09-20 | | 公開日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | The Crystal Structure of RALDH1 from Biortus.
To Be Published
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8XPX
 | | The Crystal Structure of PARP12 from Biortus. | | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Wang, F, Cheng, W, Lv, Z, Qi, J, Shen, Z. | | 登録日 | 2024-01-04 | | 公開日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | The Crystal Structure of PARP12 from Biortus.
To Be Published
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7SOL
 | | Crystal Structures of the bispecific ubiquitin/FAT10 activating enzyme, Uba6 | | 分子名称: | ADENOSINE MONOPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, Ubiquitin, ... | | 著者 | Olsen, S.K, Gao, F, Lv, Z. | | 登録日 | 2021-10-31 | | 公開日 | 2022-11-02 | | 最終更新日 | 2024-04-17 | | 実験手法 | X-RAY DIFFRACTION (2.25000644 Å) | | 主引用文献 | Crystal structures reveal catalytic and regulatory mechanisms of the dual-specificity ubiquitin/FAT10 E1 enzyme Uba6.
Nat Commun, 13, 2022
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5TUB
 | | Crystal Structure of the Shark TBC1D15 GAP Domain | | 分子名称: | Shark TBC1D15 GTPase-activating Protein | | 著者 | Chen, Y.-N, Wang, W, Cheng, D, Ge, Y, Gu, X, Zhou, X.E, Ye, F, Xu, H.E, Lv, Z. | | 登録日 | 2016-11-05 | | 公開日 | 2017-02-22 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | Crystal structure of TBC1D15 GTPase-activating protein (GAP) domain and its activity on Rab GTPases.
Protein Sci., 26, 2017
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5TUC
 | | Crystal Structure of the Sus TBC1D15 GAP Domain | | 分子名称: | Sus TBC1D15 GAP Domain | | 著者 | Chen, Y.-N, Wang, W, Cheng, D, Ge, Y, Gu, X, Zhou, X.E, Ye, F, Xu, H.E, Lv, Z. | | 登録日 | 2016-11-05 | | 公開日 | 2017-02-22 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Crystal structure of TBC1D15 GTPase-activating protein (GAP) domain and its activity on Rab GTPases.
Protein Sci., 26, 2017
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5TTE
 | | Crystal Structure of an RBR E3 ubiquitin ligase in complex with an E2-Ub thioester intermediate mimic | | 分子名称: | E3 ubiquitin-protein ligase ARIH1, Ubiquitin-conjugating enzyme E2 L3, ZINC ION, ... | | 著者 | Yuan, L, Lv, Z, Olsen, S.K. | | 登録日 | 2016-11-03 | | 公開日 | 2017-08-23 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (3.501 Å) | | 主引用文献 | Structural insights into the mechanism and E2 specificity of the RBR E3 ubiquitin ligase HHARI.
Nat Commun, 8, 2017
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7K5J
 | | Structure of an E1-E2-ubiquitin thioester mimetic | | 分子名称: | ADENOSINE MONOPHOSPHATE, Ubiquitin, Ubiquitin-activating enzyme E1 1, ... | | 著者 | Yuan, L, Lv, Z, Olsen, S.K. | | 登録日 | 2020-09-16 | | 公開日 | 2021-04-28 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (3.42 Å) | | 主引用文献 | Crystal structures of an E1-E2-ubiquitin thioester mimetic reveal molecular mechanisms of transthioesterification.
Nat Commun, 12, 2021
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7LFV
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7LFU
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8FY0
 | | E3:PROTAC:target ternary complex structure (VCB/753b/BCL-xL) | | 分子名称: | Bcl-2-like protein 1, CACODYLIC ACID, Elongin-B, ... | | 著者 | Olsen, S.K, Nayak, D, Lv, D, Yuan, Y, Zhang, P, Hu, W, Lv, Z, Sung, P, Hromas, R, Zheng, G, Zhou, D. | | 登録日 | 2023-01-25 | | 公開日 | 2024-04-10 | | 実験手法 | X-RAY DIFFRACTION (2.94 Å) | | 主引用文献 | Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL.
Nat Commun, 15, 2024
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8FY2
 | | E3:PROTAC:target ternary complex structure (VCB/WH244/BCL-2) | | 分子名称: | Apoptosis regulator Bcl-2, Elongin-B, Elongin-C, ... | | 著者 | Nayak, D, Lv, D, Yuan, Y, Zhang, P, Hu, W, Ruben, E, Lv, Z, Sung, P, Hromas, R, Zheng, G, Zhou, D, Olsen, S.K. | | 登録日 | 2023-01-25 | | 公開日 | 2024-04-10 | | 実験手法 | X-RAY DIFFRACTION (2.98 Å) | | 主引用文献 | Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL.
Nat Commun, 15, 2024
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8FY1
 | | E3:PROTAC:target ternary complex structure (VCB/753b/BCL-2) | | 分子名称: | Apoptosis regulator Bcl-2, Elongin-B, Elongin-C, ... | | 著者 | Nayak, D, Lv, D, Yuan, Y, Zhang, P, Hu, W, Lv, Z, Sung, P, Hromas, R, Zheng, G, Zhou, D, Olsen, S.K. | | 登録日 | 2023-01-25 | | 公開日 | 2024-04-10 | | 実験手法 | X-RAY DIFFRACTION (2.56 Å) | | 主引用文献 | Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL.
Nat Commun, 15, 2024
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