1UK4
| Crystal structure of SARS Coronavirus Main Proteinase (3CLpro) Complexed With An Inhibitor | Descriptor: | 3C-like proteinase nsp5, 5-mer peptide of inhibitor | Authors: | Yang, H, Yang, M, Liu, Y, Bartlam, M, Ding, Y, Lou, Z, Sun, L, Zhou, Z, Ye, S, Anand, K, Pang, H, Gao, G.F, Hilgenfeld, R, Rao, Z. | Deposit date: | 2003-08-14 | Release date: | 2003-11-18 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor Proc.Natl.Acad.Sci.USA, 100, 2003
|
|
4H52
| Wild-type influenza N2 neuraminidase covalent complex with 3-fluoro-Neu5Ac | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-acetamido-3,5-dideoxy-3-fluoro-D-erythro-alpha-L-manno-non-2-ulopyranosonic acid, CALCIUM ION, ... | Authors: | Vavricka, C.J, Liu, Y, Kiyota, H, Sriwilaijaroen, N, Qi, J, Tanaka, K, Wu, Y, Li, Q, Li, Y, Yan, J, Suzuki, Y, Gao, G.F. | Deposit date: | 2012-09-18 | Release date: | 2013-02-20 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.803 Å) | Cite: | Influenza neuraminidase operates via a nucleophilic mechanism and can be targeted by covalent inhibitors Nat Commun, 4, 2013
|
|
3CI9
| Crystal Structure of the human HSBP1 | Descriptor: | Heat shock factor-binding protein 1 | Authors: | Liu, X, Xu, L, Liu, Y, Zhu, G, Zhang, X.C, Li, X, Rao, Z. | Deposit date: | 2008-03-11 | Release date: | 2009-01-20 | Last modified: | 2021-11-10 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of the hexamer of human heat shock factor binding protein 1 Proteins, 75, 2009
|
|
1P5J
| Crystal Structure Analysis of Human Serine Dehydratase | Descriptor: | L-serine dehydratase, PYRIDOXAL-5'-PHOSPHATE | Authors: | Sun, L, Liu, Y, Rao, Z. | Deposit date: | 2003-04-27 | Release date: | 2004-06-01 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystallization and preliminary crystallographic analysis of human serine dehydratase. Acta Crystallogr.,Sect.D, 59, 2003
|
|
4ZUV
| Crystal structure of Equine MHC I(Eqca-N*00602) in complexed with equine infectious anaemia virus (EIAV) derived peptide Env-RW12 | Descriptor: | ARG-VAL-GLU-ASP-VAL-THR-ASN-THR-ALA-GLU-TYR-TRP, Beta-2-microglobulin, Classical MHC class I antigen | Authors: | Yao, S, Liu, J, Qi, J, Chen, R, Zhang, N, Liu, Y, Xia, C. | Deposit date: | 2015-05-17 | Release date: | 2016-04-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural Illumination of Equine MHC Class I Molecules Highlights Unconventional Epitope Presentation Manner That Is Evolved in Equine Leukocyte Antigen Alleles J Immunol., 196, 2016
|
|
4ZUU
| Crystal structure of Equine MHC I(Eqca-N*00602) in complexed with equine infectious anaemia virus (EIAV) derived peptide Gag-CF9 | Descriptor: | Beta-2-microglobulin, CYS-THR-SER-GLU-GLU-MET-ASN-ALA-PHE, Classical MHC class I antigen | Authors: | Yao, S, Liu, J, Qi, J, Chen, R, Zhang, N, Liu, Y, Xia, C. | Deposit date: | 2015-05-17 | Release date: | 2016-04-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural Illumination of Equine MHC Class I Molecules Highlights Unconventional Epitope Presentation Manner That Is Evolved in Equine Leukocyte Antigen Alleles J Immunol., 196, 2016
|
|
4ZUT
| Crystal structure of Equine MHC I(Eqca-N*00602) in complexed with equine infectious anaemia virus (EIAV) derived peptide Gag-GW12 | Descriptor: | Beta-2-microglobulin, Classical MHC class I antigen, GLY-SER-GLN-LYS-LEU-THR-THR-GLY-ASN-CYS-ASN-TRP | Authors: | Yao, S, Liu, J, Qi, J, Chen, R, Zhang, N, Liu, Y, Xia, C. | Deposit date: | 2015-05-17 | Release date: | 2016-04-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural Illumination of Equine MHC Class I Molecules Highlights Unconventional Epitope Presentation Manner That Is Evolved in Equine Leukocyte Antigen Alleles J Immunol., 196, 2016
|
|
4ZUS
| Crystal structure of Equine MHC I(Eqca-N*00602) in complexed with equine infectious anaemia virus (EIAV) derived peptide REV-QW11 | Descriptor: | Beta-2-microglobulin, Classical MHC class I antigen, GLN-ALA-GLU-VAL-LEU-GLN-GLU-ARG-LEU-GLU-TRP | Authors: | Yao, S, Liu, J, Qi, J, Chen, R, Zhang, N, Liu, Y, Xia, C. | Deposit date: | 2015-05-17 | Release date: | 2016-04-06 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural Illumination of Equine MHC Class I Molecules Highlights Unconventional Epitope Presentation Manner That Is Evolved in Equine Leukocyte Antigen Alleles J Immunol., 196, 2016
|
|
4ZUW
| Crystal structure of Equine MHC I(Eqca-N*00601) in complexed with equine infectious anaemia virus (EIAV) derived peptide Gag-GW12 | Descriptor: | Beta-2-microglobulin, Classical MHC class I antigen, GLY-SER-GLN-LYS-LEU-THR-THR-GLY-ASN-CYS-ASN-TRP | Authors: | Yao, S, Liu, J, Qi, J, Chen, R, Zhang, N, Liu, Y, Xia, C. | Deposit date: | 2015-05-17 | Release date: | 2016-04-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural Illumination of Equine MHC Class I Molecules Highlights Unconventional Epitope Presentation Manner That Is Evolved in Equine Leukocyte Antigen Alleles J Immunol., 196, 2016
|
|
4XOH
| Mechanistic insights into anchorage of the contractile ring from yeast to humans | Descriptor: | Division mal foutue 1 protein | Authors: | Chen, Z, Wu, J.-Q, Wang, J, Guan, R, Sun, L, Lee, I.-J, Liu, Y, Chen, M. | Deposit date: | 2015-01-16 | Release date: | 2015-07-15 | Last modified: | 2022-03-23 | Method: | X-RAY DIFFRACTION (2.801 Å) | Cite: | Mechanistic insights into the anchorage of the contractile ring by anillin and mid1 Dev.Cell, 33, 2015
|
|
4XOI
| Structure of hsAnillin bound with RhoA(Q63L) at 2.1 Angstroms resolution | Descriptor: | Actin-binding protein anillin, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Sun, L, Guan, R, Lee, I.-J, Liu, Y, Chen, M, Wang, J, Wu, J, Chen, Z. | Deposit date: | 2015-01-16 | Release date: | 2015-07-15 | Last modified: | 2022-03-23 | Method: | X-RAY DIFFRACTION (2.092 Å) | Cite: | Mechanistic insights into the anchorage of the contractile ring by anillin and mid1 Dev.Cell, 33, 2015
|
|
4R5Y
| The complex structure of Braf V600E kinase domain with a novel Braf inhibitor | Descriptor: | 5-({(1R,1aS,6bR)-1-[5-(trifluoromethyl)-1H-benzimidazol-2-yl]-1a,6b-dihydro-1H-cyclopropa[b][1]benzofuran-5-yl}oxy)-3,4-dihydro-1,8-naphthyridin-2(1H)-one, Serine/threonine-protein kinase B-raf | Authors: | Feng, Y, Peng, H, Zhang, Y, Liu, Y, Wei, M. | Deposit date: | 2014-08-22 | Release date: | 2016-02-24 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | BGB-283, a Novel RAF Kinase and EGFR Inhibitor, Displays Potent Antitumor Activity in BRAF-Mutated Colorectal Cancers. Mol.Cancer Ther., 14, 2015
|
|
3UBU
| Crystal structure of agkisacucetin, a GpIb-binding snaclec (snake C-type lectin) that inhibits platelet | Descriptor: | Agglucetin subunit alpha-1, Agglucetin subunit beta-2, GLYCEROL, ... | Authors: | Gao, Y, Ge, H, Chen, H, Li, H, Liu, Y, Niu, L, Teng, M. | Deposit date: | 2011-10-25 | Release date: | 2012-04-11 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Crystal structure of agkisacucetin, a Gpib-binding snake C-type lectin that inhibits platelet adhesion and aggregation. Proteins, 2012
|
|
5GON
| Structures of a beta-lactam bridged analogue in complex with tubulin | Descriptor: | (3R,4R)-4-(4-methoxy-3-oxidanyl-phenyl)-3-methyl-1-(3,4,5-trimethoxyphenyl)azetidin-2-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | Authors: | Zhou, L, Liu, Y, Cheng, L, Wang, Y. | Deposit date: | 2016-07-28 | Release date: | 2017-03-22 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | Potent Antitumor Activities and Structure Basis of the Chiral beta-Lactam Bridged Analogue of Combretastatin A-4 Binding to Tubulin. J. Med. Chem., 59, 2016
|
|
7CMU
| Dopamine Receptor D3R-Gi-Pramipexole complex | Descriptor: | (6S)-N6-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Xu, P, Huang, S, Mao, C, Krumm, B, Zhou, X, Tan, Y, Huang, X.-P, Liu, Y, Shen, D.-D, Jiang, Y, Yu, X, Jiang, H, Melcher, K, Roth, B, Cheng, X, Zhang, Y, Xu, H. | Deposit date: | 2020-07-29 | Release date: | 2021-03-10 | Last modified: | 2021-04-07 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structures of the human dopamine D3 receptor-G i complexes. Mol.Cell, 81, 2021
|
|
7CMV
| Dopamine Receptor D3R-Gi-PD128907 complex | Descriptor: | (4aR,10bR)-4-propyl-3,4a,5,10b-tetrahydro-2H-chromeno[4,3-b][1,4]oxazin-9-ol, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Xu, P, Huang, S, Mao, C, Krumm, B, Zhou, X, Tan, Y, Huang, X.-P, Liu, Y, Shen, D.-D, Jiang, Y, Yu, X, Jiang, H, Melcher, K, Roth, B, Cheng, X, Zhang, Y, Xu, H. | Deposit date: | 2020-07-29 | Release date: | 2021-03-10 | Last modified: | 2021-04-07 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Structures of the human dopamine D3 receptor-G i complexes. Mol.Cell, 81, 2021
|
|
7C3V
| Structure of a thermostable Alcohol dehydrogenase from Kluyveromyces polyspora(KpADH) | Descriptor: | Alcohol dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Dai, W, Ni, Y, Xu, G, Liu, Y, Wang, Y, Zhou, J. | Deposit date: | 2020-05-14 | Release date: | 2021-05-19 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.20042944 Å) | Cite: | Structure of a thermostable Alcohol dehydrogenase from Kluyveromyces polyspora(KpADH) To Be Published
|
|
3NGM
| Crystal structure of lipase from Gibberella zeae | Descriptor: | Extracellular lipase | Authors: | Lou, Z.Y, Li, M, Sun, Y.N, Liu, Y, Liu, Z, Rao, Z.H. | Deposit date: | 2010-06-12 | Release date: | 2011-05-25 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structure of a secreted lipase from Gibberella zeae reveals a novel "double-lock" mechanism Protein Cell, 1, 2010
|
|
1KSW
| Structure of Human c-Src Tyrosine Kinase (Thr338Gly Mutant) in Complex with N6-benzyl ADP | Descriptor: | N6-BENZYL ADENOSINE-5'-DIPHOSPHATE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC | Authors: | Witucki, L.A, Huang, X, Shah, K, Liu, Y, Kyin, S, Eck, M.J, Shokat, K.M. | Deposit date: | 2002-01-14 | Release date: | 2002-02-27 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Mutant tyrosine kinases with unnatural nucleotide specificity retain the structure and phospho-acceptor specificity of the wild-type enzyme. Chem.Biol., 9, 2002
|
|
1NH9
| Crystal Structure of a DNA Binding Protein Mja10b from the hyperthermophile Methanococcus jannaschii | Descriptor: | DNA-binding protein Alba | Authors: | Wang, G, Bartlam, M, Guo, R, Yang, H, Xue, H, Liu, Y, Huang, L, Rao, Z. | Deposit date: | 2002-12-19 | Release date: | 2003-12-23 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of a DNA binding protein from the hyperthermophilic euryarchaeon Methanococcus jannaschii Protein Sci., 12, 2003
|
|
1NY3
| Crystal structure of ADP bound to MAP KAP kinase 2 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAP kinase-activated protein kinase 2 | Authors: | Underwood, K.W, Parris, K.D, Federico, E, Mosyak, L, Shane, T, Taylor, M, Svenson, K, Liu, Y, Hsiao, C.L, Wolfrom, S, Maguire, M, Malakian, K, Telliez, J.B, Lin, L.L, Kriz, R.W, Seehra, J, Somers, W.S, Stahl, M.L. | Deposit date: | 2003-02-11 | Release date: | 2003-10-14 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Catalytically active MAP KAP kinase 2 structures in complex with staurosporine and ADP reveal differences with the autoinhibited enzyme Structure, 11, 2003
|
|
1NXK
| Crystal structure of staurosporine bound to MAP KAP kinase 2 | Descriptor: | MAP kinase-activated protein kinase 2, STAUROSPORINE, SULFATE ION | Authors: | Underwood, K.W, Parris, K.D, Federico, E, Mosyak, L, Czerwinski, R.M, Shane, T, Taylor, M, Svenson, K, Liu, Y, Hsiao, C.L, Wolfrom, S, Malakian, K, Telliez, J.B, Lin, L.L, Kriz, R.W, Seehra, J, Somers, W.S, Stahl, M.L. | Deposit date: | 2003-02-10 | Release date: | 2003-10-14 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Catalytically active MAP KAP kinase 2 structures in complex with staurosporine and ADP reveal differences with the autoinhibited enzyme Structure, 11, 2003
|
|
3H3B
| Crystal structure of the single-chain Fv (scFv) fragment of an anti-ErbB2 antibody chA21 in complex with residues 1-192 of ErbB2 extracellular domain | Descriptor: | Receptor tyrosine-protein kinase erbB-2, anti-ErbB2 antibody chA21 | Authors: | Zhou, H, Liu, Y, Niu, L, Zhu, J, Teng, M. | Deposit date: | 2009-04-16 | Release date: | 2010-04-28 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Structural Insights into the Down-regulation of Overexpressed p185her2/neu Protein of Transformed Cells by the Antibody chA21. J.Biol.Chem., 286, 2011
|
|
1VGK
| The crystal structure of class I Major histocompatibility complex, H-2Kd at 2.0 A resolution | Descriptor: | Beta-2-microglobulin, H-2 class I histocompatibility antigen, K-D alpha chain, ... | Authors: | Zhou, M, Xu, Y, Liu, Y, Gao, G.F, Tien, P, Rao, Z. | Deposit date: | 2004-04-27 | Release date: | 2005-06-28 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | The crystal structure of class I major histocompatibility complex, H-2Kd at 2.0 A resolution To be Published
|
|
1WDF
| crystal structure of MHV spike protein fusion core | Descriptor: | E2 glycoprotein | Authors: | Xu, Y, Liu, Y, Lou, Z, Qin, L, Li, X, Bai, Z, Tien, P, Gao, G.F, Rao, Z. | Deposit date: | 2004-05-14 | Release date: | 2004-06-15 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural Basis for Coronavirus-mediated Membrane Fusion: CRYSTAL STRUCTURE OF MOUSE HEPATITIS VIRUS SPIKE PROTEIN FUSION CORE J.Biol.Chem., 279, 2004
|
|