Crystal structure of staurosporine bound to MAP KAP kinase 2

Summary for 1NXK

DescriptorMAP kinase-activated protein kinase 2, STAUROSPORINE, SULFATE ION, ... (4 entities in total)
Functional Keywordsprotein kinase, mk2, phosphorylation, staurosporine, transferase
Biological sourceHomo sapiens (human)
Total number of polymer chains4
Total molecular weight186828.14
Primary citation
Underwood, K.W.,Parris, K.D.,Federico, E.,Mosyak, L.,Czerwinski, R.M.,Shane, T.,Taylor, M.,Svenson, K.,Liu, Y.,Hsiao, C.L.,Wolfrom, S.,Maguire, M.,Malakian, K.,Telliez, J.B.,Lin, L.L.,Kriz, R.W.,Seehra, J.,Somers, W.S.,Stahl, M.L.
Catalytically active MAP KAP kinase 2 structures in complex with staurosporine and ADP reveal differences with the autoinhibited enzyme
Structure, 11:627-636, 2003
PubMed: 12791252 (PDB entries with the same primary citation)
DOI: 10.1016/S0969-2126(03)00092-3
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers303.4%10.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution