1NXK

Crystal structure of staurosporine bound to MAP KAP kinase 2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	MAP kinase-activated protein kinase 2	polymer	400	46192.5	4	UniProt (P49137) Pfam (PF00069)	Homo sapiens (human)	MAPK-activated protein kinase 2, MAPKAP kinase 2, MAPKAPK-2
2	E, H, I, J (A, B, C, D)	STAUROSPORINE	non-polymer		466.5	4	Chemie (STU) PubChem (5279) PubChem (71203703) PubChem (42610657) PubChem (44259) PubChem (44299148) PubChem (49831000) PubChem (25322871) PubChem (28684983) PubChem (44120114) PubChem (44537813) PubChem (46864193) PubChem (68262703) PubChem (68306294) PubChem (451705) PubChem (73953205) PubChem (86306248) PubChem (358479) PubChem (5280487) PubChem (5459111) PubChem (5311103) PubChem (6711321) PubChem (9956178) PubChem (6419748) PubChem (9804568) PubChem (122130844) PubChem (12046017) PubChem (9937179) PubChem (143163481) PubChem (143224059) PubChem (143494026) PubChem (162978898)
3	F, G (B)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
4	K, L, M, N (A, B, C, D)	water	water		18.0	42	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 400 (UniProt: P49137)

PDB	External Database	Details
Mse 94	Met 94	modified residue
Mse 138	Met 138	modified residue
Mse 167	Met 167	modified residue
Mse 246	Met 246	modified residue
Mse 253	Met 253	modified residue
Mse 275	Met 275	modified residue
Mse 281	Met 281	modified residue
Mse 300	Met 300	modified residue
Mse 314	Met 314	modified residue
Mse 320	Met 320	modified residue
Mse 326	Met 326	modified residue
Mse 356	Met 356	modified residue

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	184769.9
Non-Polymers*	Number of molecules	6
	Total formula weight	2058.3
All*	Total formula weight	186828.1

*Water molecules are not included.