7EOD
 
 | | MITF HLHLZ Delta AKE | | Descriptor: | GLYCEROL, Isoform M1 of Microphthalmia-associated transcription factor | | Authors: | Li, P, Liu, Z, Fang, P, Wang, J. | | Deposit date: | 2021-04-22 | | Release date: | 2022-04-27 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy.
Cell Res., 33, 2023
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5JEJ
 | | Phosphorylated STING in complex with IRF-3 CTD | | Descriptor: | Interferon regulatory factor 3, Stimulator of interferon genes protein | | Authors: | Li, P, Shu, C. | | Deposit date: | 2016-04-18 | | Release date: | 2016-06-15 | | Last modified: | 2016-06-29 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins.
Proc.Natl.Acad.Sci.USA, 113, 2016
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6IZC
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6IZD
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3U9J
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3TWY
 | | RAT PKC C2 DOMAIN BOUND TO PB | | Descriptor: | LEAD (II) ION, Protein kinase C alpha type, SULFATE ION | | Authors: | Li, P. | | Deposit date: | 2011-09-22 | | Release date: | 2011-11-02 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Pb2+ as Modulator of Protein-Membrane Interactions.
J.Am.Chem.Soc., 133, 2011
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2M0Q
 | | Solution NMR analysis of intact KCNE2 in detergent micelles demonstrate a straight transmembrane helix | | Descriptor: | Potassium voltage-gated channel subfamily E member 2 | | Authors: | Lai, C, Li, P, Chen, L, Zhang, L, Wu, F, Tian, C. | | Deposit date: | 2012-11-01 | | Release date: | 2014-04-30 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Differential modulations of KCNQ1 by auxiliary proteins KCNE1 and KCNE2.
Sci Rep, 4, 2014
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4LEV
 | | Structure of human cGAS | | Descriptor: | Cyclic GMP-AMP synthase, ZINC ION | | Authors: | Li, P. | | Deposit date: | 2013-06-26 | | Release date: | 2013-12-25 | | Last modified: | 2014-01-08 | | Method: | X-RAY DIFFRACTION (1.952 Å) | | Cite: | Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization.
Immunity, 39, 2013
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4LEZ
 | | Structure of mouse cGAS bound to an 18bp DNA and cGAS product | | Descriptor: | 18bp dsDNA, Cyclic GMP-AMP synthase, ZINC ION, ... | | Authors: | Li, P. | | Deposit date: | 2013-06-26 | | Release date: | 2013-12-25 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.36 Å) | | Cite: | Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization.
Immunity, 39, 2013
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4LEW
 | | Structure of human cGAS | | Descriptor: | Cyclic GMP-AMP synthase, ZINC ION | | Authors: | Li, P. | | Deposit date: | 2013-06-26 | | Release date: | 2013-12-25 | | Last modified: | 2014-01-08 | | Method: | X-RAY DIFFRACTION (2.04 Å) | | Cite: | Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization.
Immunity, 39, 2013
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4LEY
 | | Structure of mouse cGAS bound to 18 bp DNA | | Descriptor: | 18 bp dsDNA, Cyclic GMP-AMP synthase, ZINC ION | | Authors: | Li, P. | | Deposit date: | 2013-06-26 | | Release date: | 2013-12-25 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization.
Immunity, 39, 2013
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3E3H
 | | Crystal structure of the OP hydrolase mutant from Brevundimonas diminuta | | Descriptor: | COBALT (II) ION, DIETHYL 4-METHYLBENZYLPHOSPHONATE, Parathion hydrolase | | Authors: | Li, P, Reeves, T.E, Grimsley, J.K, Wild, J.R. | | Deposit date: | 2008-08-07 | | Release date: | 2008-10-07 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Balancing the stability and the catalytic specificities of OP hydrolases with enhanced V-agent activities.
Protein Eng.Des.Sel., 21, 2008
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6O8C
 | | Crystal structure of STING CTT in complex with TBK1 | | Descriptor: | N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide, Serine/threonine-protein kinase TBK1, Stimulator of interferon genes protein | | Authors: | Li, P, Zhao, B, Du, F. | | Deposit date: | 2019-03-09 | | Release date: | 2019-05-22 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (3.17 Å) | | Cite: | A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1.
Nature, 569, 2019
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6O8B
 | | Crystal structure of STING CTD in complex with TBK1 | | Descriptor: | N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide, Serine/threonine-protein kinase TBK1, Stimulator of interferon genes protein | | Authors: | Li, P, Zhao, B, Du, F. | | Deposit date: | 2019-03-09 | | Release date: | 2019-05-22 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1.
Nature, 569, 2019
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3OG8
 | | Crystal structure of human RIG-I CTD bound to a 14-bp blunt-ended dsRNA | | Descriptor: | Antiviral innate immune response receptor RIG-I, RNA (5'-R(*GP*GP*CP*GP*CP*GP*CP*GP*CP*GP*CP*GP*CP*C)-3'), ZINC ION | | Authors: | Li, P. | | Deposit date: | 2010-08-16 | | Release date: | 2010-11-03 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal structure of RIG-I C-terminal domain bound to blunt-ended double-strand RNA without 5' triphosphate.
Nucleic Acids Res., 39, 2011
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3RDJ
 | | Rat PKC C2 domain Apo | | Descriptor: | Protein kinase C alpha type | | Authors: | Li, P. | | Deposit date: | 2011-04-01 | | Release date: | 2011-09-07 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Pb2+ as modulator of protein-membrane interactions.
J.Am.Chem.Soc., 133, 2011
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7JFM
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7JFL
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5V5F
 | | Crystal structure of RICE1 (PNT2) | | Descriptor: | At3g11770 | | Authors: | Li, P. | | Deposit date: | 2017-03-14 | | Release date: | 2017-09-13 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2.945 Å) | | Cite: | RISC-interacting clearing 3'- 5' exoribonucleases (RICEs) degrade uridylated cleavage fragments to maintain functional RISC in Arabidopsis thaliana.
Elife, 6, 2017
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3S2X
 | | Structure of acetyl-Coenzyme A synthase Alpha subunit C-terminal domain | | Descriptor: | NICKEL (II) ION, acetyl-CoA synthase subunit alpha | | Authors: | Li, P. | | Deposit date: | 2011-05-17 | | Release date: | 2011-07-27 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Insights into the Mechanistic Role of the [Fe(4) S(4) ] Cubane in the A-Cluster {[Fe(4) S(4) ]-(SR)-[Ni(p) Ni(d) ]} of Acetyl-Coenzyme A Synthase.
Chembiochem, 12, 2011
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3U9M
 | | Structure of reduced human FBXL5 hemerythrin like domain | | Descriptor: | F-box/LRR-repeat protein 5, FE (III) ION | | Authors: | Li, P. | | Deposit date: | 2011-10-19 | | Release date: | 2012-02-22 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | The Structural Basis of Iron Sensing by the Human F-box Protein FBXL5.
Chembiochem, 13, 2012
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6AEM
 | | Crystal structure of the PKD1 domain of Vibrio anguillarum Epp | | Descriptor: | CALCIUM ION, PKD domain, ZINC ION | | Authors: | Ma, Q, Li, P. | | Deposit date: | 2018-08-05 | | Release date: | 2018-12-12 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.272 Å) | | Cite: | Structural basis for specific calcium binding by the polycystic-kidney-disease domain of Vibrio anguillarum protease Epp
Biochem. Biophys. Res. Commun., 505, 2018
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3LRR
 | | Crystal structure of human RIG-I CTD bound to a 12 bp AU rich 5' ppp dsRNA | | Descriptor: | Probable ATP-dependent RNA helicase DDX58, RNA (5'-R(*(ATP)P*UP*AP*UP*AP*UP*AP*UP*AP*UP*AP*U)-3'), ZINC ION | | Authors: | Li, P. | | Deposit date: | 2010-02-11 | | Release date: | 2010-06-02 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | The Structural Basis of 5' Triphosphate Double-Stranded RNA Recognition by RIG-I C-Terminal Domain.
Structure, 18, 2010
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3LRN
 | | Crystal structure of human RIG-I CTD bound to a 14 bp GC 5' ppp dsRNA | | Descriptor: | Probable ATP-dependent RNA helicase DDX58, RNA (5'-R(*(GTP)P*GP*CP*GP*CP*GP*CP*GP*CP*GP*CP*GP*CP*C)-3'), ZINC ION | | Authors: | Li, P. | | Deposit date: | 2010-02-11 | | Release date: | 2010-06-02 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | The Structural Basis of 5' Triphosphate Double-Stranded RNA Recognition by RIG-I C-Terminal Domain.
Structure, 18, 2010
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4EMT
 | | Crystal Structure of human STING bound to c-di-GMP | | Descriptor: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), CALCIUM ION, Transmembrane protein 173 | | Authors: | Li, P. | | Deposit date: | 2012-04-12 | | Release date: | 2012-06-13 | | Last modified: | 2012-07-25 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system.
Nat.Struct.Mol.Biol., 19, 2012
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