4LEZ

Structure of mouse cGAS bound to an 18bp DNA and cGAS product

Summary for 4LEZ

• Entry DOI: 10.2210/pdb4lez/pdb
• Related: 4LEV 4LEw 4LEy
• Descriptor: Cyclic GMP-AMP synthase, 18bp dsDNA, ZINC ION, ... (5 entities in total)
• Functional Keywords: ntase, dna sensor, transferase-dna complex, transferase/dna
• Biological source: Mus musculus (mouse); More
• Cellular location: Cytoplasm, cytosol : Q8C6L5
• Total number of polymer chains: 6
• Total formula weight: 109507.38

Authors

Li, P. (deposition date: 2013-06-26, release date: 2013-12-25, Last modification date: 2024-03-13)

• Primary citation: Li, X.,Shu, C.,Yi, G.,Chaton, C.T.,Shelton, C.L.,Diao, J.,Zuo, X.,Kao, C.C.,Herr, A.B.,Li, P.; Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization.; Immunity, 39:1019-1031, 2013; PubMed: 24332030; DOI: 10.1016/j.immuni.2013.10.019

Experimental method

X-RAY DIFFRACTION (2.36 Å)