2MX0
 
 | | Solution structure of HP0268 from Helicobacter pylori | | 分子名称: | Uncharacterized protein HP_0268 | | 著者 | Lee, K.Y. | | 登録日 | 2014-12-05 | | 公開日 | 2015-12-09 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure-based functional identification of Helicobacter pylori HP0268 as a nuclease with both DNA nicking and RNase activities
Nucleic Acids Res., 43, 2015
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8YPJ
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6OS4
 | | Calmodulin in complex with farnesyl cysteine methyl ester | | 分子名称: | CALCIUM ION, Calmodulin-1, s-farnesyl-l-cysteine methyl ester | | 著者 | Grant, B.M.M, Enomoto, M, Lee, K.Y, Back, S.I, Gebregiworgis, T, Ishiyama, N, Ikura, M, Marshall, C. | | 登録日 | 2019-05-01 | | 公開日 | 2020-04-08 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Calmodulin disrupts plasma membrane localization of farnesylated KRAS4b by sequestering its lipid moiety.
Sci.Signal., 13, 2020
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6W4F
 | | NMR-driven structure of KRAS4B-GDP homodimer on a lipid bilayer nanodisc | | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Apolipoprotein A-I, GTPase KRas, ... | | 著者 | Lee, K, Fang, Z, Enomoto, M, Gasmi-Seabrook, G.M, Zheng, L, Marshall, C.B, Ikura, M. | | 登録日 | 2020-03-10 | | 公開日 | 2020-04-29 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Two Distinct Structures of Membrane-Associated Homodimers of GTP- and GDP-Bound KRAS4B Revealed by Paramagnetic Relaxation Enhancement.
Angew.Chem.Int.Ed.Engl., 59, 2020
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6W4E
 | | NMR-driven structure of KRAS4B-GTP homodimer on a lipid bilayer nanodisc | | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Apolipoprotein A-I, ... | | 著者 | Lee, K, Fang, Z, Enomoto, M, Gasmi-Seabrook, G.M, Zheng, L, Marshall, C.B, Ikura, M. | | 登録日 | 2020-03-10 | | 公開日 | 2020-04-15 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Two Distinct Structures of Membrane-Associated Homodimers of GTP- and GDP-Bound KRAS4B Revealed by Paramagnetic Relaxation Enhancement.
Angew.Chem.Int.Ed.Engl., 59, 2020
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7RSC
 | | NMR-driven structure of the KRAS4B-G12D "alpha-alpha" dimer on a lipid bilayer nanodisc | | 分子名称: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Apolipoprotein A-I, GTPase KRas, ... | | 著者 | Lee, K, Enomoto, M, Gebregiworgis, T, Gasmi-Seabrook, G.M, Ikura, M, Marshall, C.B. | | 登録日 | 2021-08-11 | | 公開日 | 2021-09-22 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Oncogenic KRAS G12D mutation promotes dimerization through a second, phosphatidylserine-dependent interface: a model for KRAS oligomerization.
Chem Sci, 12, 2021
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7RSE
 | | NMR-driven structure of the KRAS4B-G12D "alpha-beta" dimer on a lipid bilayer nanodisc | | 分子名称: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Apolipoprotein A-I, GTPase KRas, ... | | 著者 | Lee, K, Enomoto, M, Gebregiworgis, T, Gasmi-Seabrook, G.M, Ikura, M, Marshall, C.B. | | 登録日 | 2021-08-11 | | 公開日 | 2021-09-22 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Oncogenic KRAS G12D mutation promotes dimerization through a second, phosphatidylserine-dependent interface: a model for KRAS oligomerization.
Chem Sci, 12, 2021
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6JKG
 | | The NAD+-free form of human NSDHL | | 分子名称: | Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating | | 著者 | Kim, D, Lee, S.J, Lee, B. | | 登録日 | 2019-02-28 | | 公開日 | 2020-03-04 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Crystal structures of human NSDHL and development of its novel inhibitor with the potential to suppress EGFR activity.
Cell.Mol.Life Sci., 78, 2021
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6JKH
 | | The NAD+-bound form of human NSDHL | | 分子名称: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating | | 著者 | Kim, D, Lee, S.J, Lee, B. | | 登録日 | 2019-02-28 | | 公開日 | 2020-03-04 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Crystal structures of human NSDHL and development of its novel inhibitor with the potential to suppress EGFR activity.
Cell.Mol.Life Sci., 78, 2021
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3UI3
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4XGQ
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4XGR
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6PTS
 | | NMR data-driven model of KRas-GMPPNP:RBD-CRD complex tethered to a nanodisc (state A) | | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Apolipoprotein A-I, GTPase KRas, ... | | 著者 | Fang, Z, Lee, K, Gasmi-Seabrook, G, Ikura, M, Marshall, C.B. | | 登録日 | 2019-07-16 | | 公開日 | 2020-05-13 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Multivalent assembly of KRAS with the RAS-binding and cysteine-rich domains of CRAF on the membrane.
Proc.Natl.Acad.Sci.USA, 117, 2020
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6PTW
 | | NMR data-driven model of KRas-GMPPNP:RBD-CRD complex tethered to a nanodisc (state B) | | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Apolipoprotein A-I, GTPase KRas, ... | | 著者 | Fang, Z, Lee, K, Gasmi-Seabrook, G, Ikura, M, Marshall, C.B. | | 登録日 | 2019-07-16 | | 公開日 | 2020-05-13 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Multivalent assembly of KRAS with the RAS-binding and cysteine-rich domains of CRAF on the membrane.
Proc.Natl.Acad.Sci.USA, 117, 2020
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4QXZ
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6IFM
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6IFC
 | | Crystal structure of VapBC from Salmonella typhimurium | | 分子名称: | Antitoxin VapB, CALCIUM ION, tRNA(fMet)-specific endonuclease VapC | | 著者 | Park, D.W, Lee, B.J. | | 登録日 | 2018-09-19 | | 公開日 | 2020-01-29 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | | 主引用文献 | Crystal structure of proteolyzed VapBC and DNA-bound VapBC from Salmonella enterica Typhimurium LT2 and VapC as a putative Ca2+-dependent ribonuclease.
Faseb J., 34, 2020
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1DFW
 | | CONFORMATIONAL MAPPING OF THE N-TERMINAL SEGMENT OF SURFACTANT PROTEIN B IN LIPID USING 13C-ENHANCED FOURIER TRANSFORM INFRARED SPECTROSCOPY (FTIR) | | 分子名称: | LUNG SURFACTANT PROTEIN B | | 著者 | Gordon, L.M, Lee, K.Y.C, Lipp, M.M, Zasadzinski, J.A, Walther, F.J, Sherman, M.A, Waring, A.J. | | 登録日 | 1999-11-22 | | 公開日 | 1999-12-10 | | 最終更新日 | 2024-02-07 | | 実験手法 | INFRARED SPECTROSCOPY | | 主引用文献 | Conformational mapping of the N-terminal segment of surfactant protein B in lipid using 13C-enhanced Fourier transform infrared spectroscopy.
J.Pept.Res., 55, 2000
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4Z9E
 | | Alba from Thermoplasma volcanium | | 分子名称: | DNA/RNA-binding protein Alba | | 著者 | Ma, C, Lee, S.J, Pathak, C, Lee, B.J. | | 登録日 | 2015-04-10 | | 公開日 | 2016-02-24 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | | 主引用文献 | Alba from Thermoplasma volcanium belongs to alpha-NAT's: An insight into the structural aspects of Tv Alba and its acetylation by Tv Ard1.
Arch.Biochem.Biophys., 590, 2016
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4Z1A
 | | Structure of apo form KDO8PS from H.pylori | | 分子名称: | 2-dehydro-3-deoxyphosphooctonate aldolase | | 著者 | Lee, B.J, Cho, S, Im, H, Yoon, H.J. | | 登録日 | 2015-03-27 | | 公開日 | 2016-03-09 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Identification of novel scaffolds for potential anti-Helicobacter pylori agents based on the crystal structure of H. pylori 3-deoxy-d-manno-octulosonate 8-phosphate synthase (HpKDO8PS).
Eur.J.Med.Chem., 108, 2016
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4Z1D
 | | Structure of PEP and zinc bound KDO8PS from H.pylori | | 分子名称: | 2-dehydro-3-deoxyphosphooctonate aldolase, PHOSPHOENOLPYRUVATE, ZINC ION | | 著者 | Lee, B.J, Cho, S, Im, H, Yoon, H.J. | | 登録日 | 2015-03-27 | | 公開日 | 2016-03-09 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Identification of novel scaffolds for potential anti-Helicobacter pylori agents based on the crystal structure of H. pylori 3-deoxy-d-manno-octulosonate 8-phosphate synthase (HpKDO8PS).
Eur.J.Med.Chem., 108, 2016
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4Z1B
 | | Structure of H204A mutant KDO8PS from H.pylori | | 分子名称: | 2-dehydro-3-deoxyphosphooctonate aldolase | | 著者 | Lee, B.J, Cho, S, Im, H, Yoon, H.J. | | 登録日 | 2015-03-27 | | 公開日 | 2016-03-09 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Identification of novel scaffolds for potential anti-Helicobacter pylori agents based on the crystal structure of H. pylori 3-deoxy-d-manno-octulosonate 8-phosphate synthase (HpKDO8PS).
Eur.J.Med.Chem., 108, 2016
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4Z1C
 | | Structure of Cadmium bound KDO8PS from H.pylori | | 分子名称: | 2-dehydro-3-deoxyphosphooctonate aldolase, CADMIUM ION | | 著者 | Lee, B.J, Cho, S, Im, H, Yoon, H.J. | | 登録日 | 2015-03-27 | | 公開日 | 2016-03-09 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | | 主引用文献 | Identification of novel scaffolds for potential anti-Helicobacter pylori agents based on the crystal structure of H. pylori 3-deoxy-d-manno-octulosonate 8-phosphate synthase (HpKDO8PS).
Eur.J.Med.Chem., 108, 2016
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5HS9
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5HS7
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