4QXZ

Crystal structure of a hypothetical protein from Staphylococcus aureus

Summary for 4QXZ

• Entry DOI: 10.2210/pdb4qxz/pdb
• Descriptor: Uncharacterized protein (2 entities in total)
• Functional Keywords: beta-barrel, unknown function
• Biological source: Staphylococcus aureus subsp. aureus Mu50
• Total number of polymer chains: 2
• Total formula weight: 38657.75

Authors

Lee, B.-J.,Lee, S.J.,Lee, K.-Y. (deposition date: 2014-07-23, release date: 2015-06-10, Last modification date: 2024-03-20)

Primary citation

Lee, S.J.,Lee, K.Y.,Lee, K.Y.,Kim, D.G.,Kim, S.J.,Lee, B.J.
Crystal structure of YwpF from Staphylococcus aureus reveals its architecture comprised of a beta-barrel core domain resembling type VI secretion system proteins and a two-helix pair.
Proteins, 83:781-788, 2015

PubMed Abstract: The ywpF gene (SAV2097) of the Staphylococcus aureus strain Mu50 encodes the YwpF protein, which may play a role in antibiotic resistance. Here, we report the first crystal structure of the YwpF superfamily from S. aureus at 2.5-Å resolution. The YwpF structure consists of two regions: an N-terminal core β-barrel domain that shows structural similarity to type VI secretion system (T6SS) proteins (e.g., Hcp1, Hcp3, and EvpC) and a C-terminal two-helix pair. Although the monomer structure of S. aureus YwpF resembles those of T6SS proteins, the dimer/tetramer model of S. aureus YwpF is distinct from the functionally important hexameric ring of T6SS proteins. We therefore suggest that the S. aureus YwpF may have a different function compared to T6SS proteins.

PubMed: 25663006
DOI: 10.1002/prot.24774

Experimental method

X-RAY DIFFRACTION (2.49 Å)