6JKG

The NAD+-free form of human NSDHL

Summary for 6JKG

• Entry DOI: 10.2210/pdb6jkg/pdb
• Descriptor: Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (2 entities in total)
• Functional Keywords: cholesterol, dehydrogenase, oxidoreductase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 54512.17

Authors

Kim, D.,Lee, S.J.,Lee, B. (deposition date: 2019-02-28, release date: 2020-03-04, Last modification date: 2023-11-22)

• Primary citation: Kim, D.G.,Cho, S.,Lee, K.Y.,Cheon, S.H.,Yoon, H.J.,Lee, J.Y.,Kim, D.,Shin, K.S.,Koh, C.H.,Koo, J.S.,Choi, Y.,Lee, H.H.,Oh, Y.K.,Jeong, Y.S.,Chung, S.J.,Baek, M.,Jung, K.Y.,Lim, H.J.,Kim, H.S.,Park, S.J.,Lee, J.Y.,Lee, S.J.,Lee, B.J.; Crystal structures of human NSDHL and development of its novel inhibitor with the potential to suppress EGFR activity.; Cell.Mol.Life Sci., 78:207-225, 2021; PubMed: 32140747; DOI: 10.1007/s00018-020-03490-2

Experimental method

X-RAY DIFFRACTION (2.9 Å)