4AWO
| Complex of HSP90 ATPase domain with tropane derived inhibitors | Descriptor: | 5-[(2R)-butan-2-ylamino]-N-{(3-endo)-8-[5-(cyclopropylcarbonyl)pyridin-2-yl]-8-azabicyclo[3.2.1]oct-3-yl}-2-methylbenzene-1,4-dicarboxamide, HEAT SHOCK PROTEIN HSP 90-ALPHA | Authors: | Lougheed, J.C, Stout, T.J. | Deposit date: | 2012-06-05 | Release date: | 2012-08-29 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Discovery of Xl888: A Novel Tropane-Derived Small Molecule Inhibitor of Hsp90. Bioorg.Med.Chem.Lett., 22, 2012
|
|
4AWQ
| Complex of HSP90 ATPase domain with tropane derived inhibitors | Descriptor: | HEAT SHOCK PROTEIN HSP 90-ALPHA, N-benzyl-6-[(3-endo)-3-{[(3-methoxy-2-methylphenyl)carbonyl]amino}-8-azabicyclo[3.2.1]oct-8-yl]pyridine-3-carboxamide | Authors: | Lougheed, J.C, Stout, T.J. | Deposit date: | 2012-06-05 | Release date: | 2012-08-29 | Last modified: | 2017-06-28 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Discovery of Xl888: A Novel Tropane-Derived Small Molecule Inhibitor of Hsp90. Bioorg.Med.Chem.Lett., 22, 2012
|
|
7V6U
| Crystal structure of bacterial peptidase | Descriptor: | 1,2-ETHANEDIOL, D-MALATE, Murein DD-endopeptidase MepS/Murein LD-carboxypeptidase | Authors: | Kim, Y, Lee, W.C. | Deposit date: | 2021-08-20 | Release date: | 2022-08-24 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.144 Å) | Cite: | The crystal structure of bacterial DD-endopeptidase To be published
|
|
7V6S
| Crystal structure of bacterial peptidase | Descriptor: | Murein DD-endopeptidase MepS/Murein LD-carboxypeptidase | Authors: | Kim, Y, Lee, W.C. | Deposit date: | 2021-08-20 | Release date: | 2022-08-24 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.883 Å) | Cite: | The crystal structure fre To be published
|
|
7V6T
| Crystal structure of bacterial peptidase | Descriptor: | 1,2-ETHANEDIOL, CITRIC ACID, Murein DD-endopeptidase MepS/Murein LD-carboxypeptidase | Authors: | Kim, Y, Lee, W.C. | Deposit date: | 2021-08-20 | Release date: | 2022-08-24 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.495 Å) | Cite: | Crystal structure of bacterial DD-endopeptidase To be published
|
|
8HNS
| Crystal structure of an anti-CRISPR protein AcrIIC4 in apo form | Descriptor: | GLYCEROL, anti-CRISPR protein AcrIIC4 | Authors: | Sun, W, Cheng, Z, Yang, J, Wang, Y. | Deposit date: | 2022-12-08 | Release date: | 2023-07-19 | Last modified: | 2023-08-02 | Method: | X-RAY DIFFRACTION (2.54 Å) | Cite: | AcrIIC4 inhibits type II-C Cas9 by preventing R-loop formation. Proc.Natl.Acad.Sci.USA, 120, 2023
|
|
7CC7
| |
6LZP
| |
4ECM
| 2.3 Angstrom Crystal Structure of a Glucose-1-phosphate Thymidylyltransferase from Bacillus anthracis in Complex with Thymidine-5-diphospho-alpha-D-glucose and Pyrophosphate | Descriptor: | 2'DEOXY-THYMIDINE-5'-DIPHOSPHO-ALPHA-D-GLUCOSE, Glucose-1-phosphate thymidylyltransferase, PYROPHOSPHATE 2- | Authors: | Minasov, G, Kuhn, M, Halavaty, A, Shuvalova, L, Dubrovska, I, Winsor, J, Papazisi, L, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2012-03-26 | Release date: | 2012-04-04 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure of the Bacillus anthracis dTDP-L-rhamnose-biosynthetic enzyme glucose-1-phosphate thymidylyltransferase (RfbA). Acta Crystallogr F Struct Biol Commun, 73, 2017
|
|
2KI2
| Solution Structure of ss-DNA Binding Protein 12RNP2 Precursor, HP0827(O25501_HELPY) form Helicobacter pylori | Descriptor: | Ss-DNA binding protein 12RNP2 | Authors: | Ma, C, Lee, J, Kim, J, Park, S, Kwon, A, Lee, B. | Deposit date: | 2009-04-20 | Release date: | 2009-10-20 | Last modified: | 2022-03-16 | Method: | SOLUTION NMR | Cite: | NMR solution structure of HP0827 (O25501_HELPY) from Helicobacter pylori: model of the possible RNA-binding site J.Biochem., 146, 2009
|
|
2LN4
| |
5YX4
| Isoliquiritigenin-complexed Chalcone isomerase (S189A) from the Antarctic vascular plant Deschampsia Antarctica (DaCHI1) | Descriptor: | 2',4,4'-TRIHYDROXYCHALCONE, Chalcone-flavonone isomerase family protein | Authors: | Lee, C.W, Park, S, Lee, J.H. | Deposit date: | 2017-12-01 | Release date: | 2018-02-14 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure and enzymatic properties of chalcone isomerase from the Antarctic vascular plant Deschampsia antarctica Desv. PLoS ONE, 13, 2018
|
|
5YX3
| |
3R4Y
| Crystal structure of alpha-neoagarobiose hydrolase (ALPHA-NABH) from Saccharophagus degradans 2-40 | Descriptor: | Glycosyl hydrolase family 32, N terminal | Authors: | Lee, S, Lee, J.Y, Ha, S.C, Shin, D.H, Kim, K.H, Bang, W.G, Kim, S.H, Choi, I.G. | Deposit date: | 2011-03-18 | Release date: | 2012-02-01 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of a key enzyme in the agarolytic pathway, alpha-neoagarobiose hydrolase from Saccharophagus degradans 2-40 Biochem.Biophys.Res.Commun., 412, 2011
|
|
8HNV
| CryoEM structure of HpaCas9-sgRNA-dsDNA in the presence of AcrIIC4 | Descriptor: | CRISPR-associated endonuclease Cas9, anti-CRISPR protein AcrIIC4, non-target strand, ... | Authors: | Sun, W, Cheng, Z, Wang, J, Yang, X, Wang, Y. | Deposit date: | 2022-12-08 | Release date: | 2023-07-19 | Last modified: | 2023-08-02 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | AcrIIC4 inhibits type II-C Cas9 by preventing R-loop formation. Proc.Natl.Acad.Sci.USA, 120, 2023
|
|
7VYT
| Crystal structure of human TIGIT(23-129) in complex with the scFv fragment of anti-TIGIT antibody MG1131 | Descriptor: | CITRATE ANION, MG1131 heavy chain variable region, MG1131 light chain variable region, ... | Authors: | Jeong, B.-S, Nam, H, Kim, M, Oh, B.-H. | Deposit date: | 2021-11-15 | Release date: | 2022-03-02 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.53 Å) | Cite: | Structural and functional characterization of a monoclonal antibody blocking TIGIT. Mabs, 14, 2022
|
|
7EEW
| |
2QBR
| Crystal structure of ptp1b-inhibitor complex | Descriptor: | 5-[3-(BENZYLAMINO)PHENYL]-4-BROMO-3-(CARBOXYMETHOXY)THIOPHENE-2-CARBOXYLIC ACID, Tyrosine-protein phosphatase non-receptor type 1 | Authors: | Xu, W. | Deposit date: | 2007-06-18 | Release date: | 2008-03-18 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure-based optimization of protein tyrosine phosphatase 1B inhibitors: from the active site to the second phosphotyrosine binding site. J.Med.Chem., 50, 2007
|
|
2QBQ
| Crystal structure of ptp1b-inhibitor complex | Descriptor: | 4-BROMO-3-(CARBOXYMETHOXY)-5-{3-[(3,3,5,5-TETRAMETHYLCYCLOHEXYL)AMINO]PHENYL}THIOPHENE-2-CARBOXYLIC ACID, Tyrosine-protein phosphatase non-receptor type 1 | Authors: | Xu, W. | Deposit date: | 2007-06-18 | Release date: | 2008-03-18 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure-based optimization of protein tyrosine phosphatase 1B inhibitors: from the active site to the second phosphotyrosine binding site. J.Med.Chem., 50, 2007
|
|
2QBP
| Crystal structure of ptp1b-inhibitor complex | Descriptor: | 5-(3-{[1-(BENZYLSULFONYL)PIPERIDIN-4-YL]AMINO}PHENYL)-4-BROMO-3-(CARBOXYMETHOXY)THIOPHENE-2-CARBOXYLIC ACID, Tyrosine-protein phosphatase non-receptor type 1 | Authors: | Xu, W. | Deposit date: | 2007-06-18 | Release date: | 2008-03-18 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure-based optimization of protein tyrosine phosphatase 1B inhibitors: from the active site to the second phosphotyrosine binding site. J.Med.Chem., 50, 2007
|
|
2QBS
| Crystal structure of ptp1b-inhibitor complex | Descriptor: | 4-BROMO-3-(CARBOXYMETHOXY)-5-[3-(CYCLOHEXYLAMINO)PHENYL]THIOPHENE-2-CARBOXYLIC ACID, Tyrosine-protein phosphatase non-receptor type 1 | Authors: | Xu, W. | Deposit date: | 2007-06-18 | Release date: | 2008-03-18 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure-based optimization of protein tyrosine phosphatase 1B inhibitors: from the active site to the second phosphotyrosine binding site. J.Med.Chem., 50, 2007
|
|
3BF7
| |
3BF8
| |
7R40
| Structure of the SARS-CoV-2 spike glycoprotein in complex with the 87G7 antibody Fab fragment | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 87G7 heavy chain variable region, ... | Authors: | Hurdiss, D.L. | Deposit date: | 2022-02-08 | Release date: | 2022-04-20 | Last modified: | 2023-12-13 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | An ACE2-blocking antibody confers broad neutralization and protection against Omicron and other SARS-CoV-2 variants of concern. Sci Immunol, 7, 2022
|
|
7C2S
| Helical reconstruction of Dengue virus serotype 3 complexed with Fab C10 | Descriptor: | Heavy chain of Fab C10, envelope protein, light chain of Fab C10 | Authors: | Morrone, S, Chew, S.V, Lim, X.N, Ng, T.S, Kostyuchenko, V.A, Zhang, S, Lok, S.M. | Deposit date: | 2020-05-09 | Release date: | 2020-07-08 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (10.4 Å) | Cite: | High flavivirus structural plasticity demonstrated by a non-spherical morphological variant. Nat Commun, 11, 2020
|
|