7VYT
Crystal structure of human TIGIT(23-129) in complex with the scFv fragment of anti-TIGIT antibody MG1131
Summary for 7VYT
Entry DOI | 10.2210/pdb7vyt/pdb |
Descriptor | T-cell immunoreceptor with Ig and ITIM domains, MG1131 heavy chain variable region, MG1131 light chain variable region, ... (5 entities in total) |
Functional Keywords | antibody, immune checkpoint, tigit, immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 77343.30 |
Authors | Jeong, B.-S.,Nam, H.,Kim, M.,Oh, B.-H. (deposition date: 2021-11-15, release date: 2022-03-02, Last modification date: 2023-11-29) |
Primary citation | Jeong, B.S.,Nam, H.,Lee, J.,Park, H.Y.,Cho, K.J.,Sheen, J.H.,Song, E.,Oh, M.,Lee, S.,Choi, H.,Yang, J.E.,Kim, M.,Oh, B.H. Structural and functional characterization of a monoclonal antibody blocking TIGIT. Mabs, 14:2013750-2013750, 2022 Cited by PubMed: 35090381DOI: 10.1080/19420862.2021.2013750 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.53 Å) |
Structure validation
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